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01-12-2020 | Basic Surgery | Original Article

Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study

Authors: Manabu Yamamoto, Kazushi Hara, Ken Sugezawa, Chihiro Uejima, Akimitsu Tanio, Yoichiro Tada, Yuji Shishido, Kozo Miyatani, Takehiko Hanaki, Kyoichi Kihara, Tomoyuki Matsunaga, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Soichiro Honjo, Yoshiyuki Fujiwara

Published in: Langenbeck's Archives of Surgery | Issue 8/2020

Abstract

Purpose

Olanexidine gluconate is a newly developed solution for skin disinfection that was recently approved in Japan. We aimed to compare single and double application of the solution in preventing surgical site infection (SSI) in patients undergoing general surgery.

Methods

This randomized study was conducted at the Tottori University Hospital. Patients scheduled to undergo gastrointestinal or hernia surgery were randomly assigned to one of two groups using either one or two Olanedine applicators for skin disinfection. The primary endpoint was the difference in SSI incidence between the two groups. The secondary endpoint was all adverse events related to olanexidine gluconate.

Results

A total of 393 patients qualified for the study protocol: 193 received a single application, and 200 received a double application of Olanedine. SSI occurred in 10 patients (2.5%) overall; nine were superficial incisional SSIs, and one patient had a deep incisional SSI. Of the 10 patients who developed SSI, six (3.1%) were in the group receiving a single application, and four (2.0%) were in the group receiving a double application; there was no statistically significant difference between the two groups (P = 0.537). Allergic reactions or skin disorders related to olanexidine gluconate were not observed.

Conclusion

There was no difference in the SSI incidence between the use of one or two Olanedine applicators for skin preparation in elective general surgery. Therefore, a single application of Olanedine is sufficient and is recommended for general surgery as a standard disinfection precaution.

Trial registration number

UMIN000027319; 5/12/2017.

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Title: Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study
Authors: Manabu Yamamoto
Kazushi Hara
Ken Sugezawa
Chihiro Uejima
Akimitsu Tanio
Yoichiro Tada
Yuji Shishido
Kozo Miyatani
Takehiko Hanaki
Kyoichi Kihara
Tomoyuki Matsunaga
Naruo Tokuyasu
Shuichi Takano
Teruhisa Sakamoto
Soichiro Honjo
Yoshiyuki Fujiwara
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Keyword: Basic Surgery
Published in: Langenbeck's Archives of Surgery / Issue 8/2020
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-020-02007-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Disinfection with single or double usage of new antiseptic olanexidine gluconate in general surgery: a randomized study

Abstract

Purpose

Methods

Results

Conclusion

Trial registration number

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Trial registration number

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