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Langenbeck's Archives of Surgery

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01-02-2020 | Pancreatectomy | Original Article

Albumin difference as a new predictor of pancreatic fistula following distal pancreatectomy: a retrospective study of 211 consecutive patients

Authors: Jian Shen, Yushun Zhang, Jin Hu, Ruozheng Wei, Heshui Wu

Published in: Langenbeck's Archives of Surgery | Issue 1/2020

Abstract

Purpose

The level of albumin declines after surgery, and whether the difference between preoperative and postoperative albumin levels on postoperative day 1 has an effect on the development of postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) is unclear. Our aim was to evaluate the effect of albumin difference on POPF.

Methods

A retrospective analysis of consecutive patients who had undergone DP between January 2016 and October 2018 at a single institution was conducted. Patient demographic data and perioperative data were analysed using univariate and multivariate models. Pancreatic fistula was defined by the 2016 International Study Group of Pancreatic Surgery criteria. All patients were followed for up to 90 days.

Results

A total of 211 consecutive patients were identified. The POPF rate was 15.64%, and no 90-day mortality was observed. Five predictors were independently associated with POPF: albumin difference (OR 6.60, 95% CI 2.36–18.45, P < 0.001), pancreatic texture (OR 4.15, 95% CI 1.62–10.63, P = 0.003), operative time (OR 3.13, 95% CI 1.19–8.24, P = 0.021), intraoperative fluid transfusion (OR 4.85, 95% CI 1.70–13.79, P = 0.003), and cardiovascular disease (OR 5.38, 95% CI 1.99–14.55, P = 0.001).

Conclusions

Although DP can be performed with a low rate of mortality, POPF remains a common complication. Albumin difference is a new, accessible predictor for POPF following DP.

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Title: Albumin difference as a new predictor of pancreatic fistula following distal pancreatectomy: a retrospective study of 211 consecutive patients
Authors: Jian Shen
Yushun Zhang
Jin Hu
Ruozheng Wei
Heshui Wu
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keyword: Pancreatectomy
Published in: Langenbeck's Archives of Surgery / Issue 1/2020
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-019-01849-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Albumin difference as a new predictor of pancreatic fistula following distal pancreatectomy: a retrospective study of 211 consecutive patients

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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