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Langenbeck's Archives of Surgery
Published in: Langenbeck's Archives of Surgery 2/2017

01-03-2017 | Controlled Clinical Trial

Randomized controlled clinical trial assessing the effects of oral nutritional supplements in postoperative gastric cancer patients

Authors: Fumihiko Hatao, Kuen-Yuan Chen, Jin-Ming Wu, Ming-Yang Wang, Susumu Aikou, Haruna Onoyama, Nobuyuki Shimizu, Kazuhiko Fukatsu, Yasuyuki Seto, Ming-Tsan Lin

Published in: Langenbeck's Archives of Surgery | Issue 2/2017

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Abstract

Background

Postoperative weight loss and malnutrition are major issues in gastric cancer patients. The concept of oral nutritional supplements (ONS) is gaining widespread acceptance. We investigated the effects of ONS administration on postoperative body weight loss in patients with gastric cancer who had undergone total gastrectomy or distal gastrectomy.

Methods

Patients were randomized to either the treatment or the control group. In both groups, standard surgery for gastric cancer was performed. In the treatment group, intervention with ONS was performed until 12 weeks after discharge. In the control group, patients were fed the usual postoperative diet. Weight, body composition, quality of life, hematological parameters, and blood chemistry were evaluated.

Results

We analyzed 113 cases (73 distal gastrectomy, 40 total gastrectomy). Weight loss in the ONS group after total gastrectomy was significantly less than that in the control group. Weight loss and skeletal muscle mass loss after distal gastrectomy did not differ significantly between the ONS and control groups.

Conclusion

This study showed ONS after total gastrectomy to significantly diminish postoperative weight loss.
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Metadata
Title
Randomized controlled clinical trial assessing the effects of oral nutritional supplements in postoperative gastric cancer patients
Authors
Fumihiko Hatao
Kuen-Yuan Chen
Jin-Ming Wu
Ming-Yang Wang
Susumu Aikou
Haruna Onoyama
Nobuyuki Shimizu
Kazuhiko Fukatsu
Yasuyuki Seto
Ming-Tsan Lin
Publication date
01-03-2017
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 2/2017
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-016-1527-8

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