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01-02-2017 | ORIGINAL ARTICLE

Relationship between the surgical margin status, prognosis, and recurrence in extrahepatic bile duct cancer patients

Authors: Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Shinichiro Mori, Yuko Kijima, Shinichi Ueno, Hiroyuki Shinchi, Sonshin Takao, Shoji Natsugoe

Published in: Langenbeck's Archives of Surgery | Issue 1/2017

Abstract

Purpose

The purpose of this retrospective study was to evaluate the relationship between the surgical margin status of the bile duct and the prognosis and recurrence of extrahepatic bile duct (EHBD) cancer.

Methods

The clinical data of 100 patients who underwent surgery for EHBD cancer between February 2002 and September 2014 were analyzed. The ductal margin status was classified into the following three categories: negative (D-N), positive with carcinoma in situ (D-CIS), and positive with invasive carcinoma (D-INV).

Results

The number of patients with D-N, D-CIS, and D-INV was 69, 16, and 15, respectively. Local recurrence rates of patients with D-CIS (56.3 %) and D-INV (66.7 %) were significantly higher compared to those of patients with D-N (10.1 %; P < 0.001). D-CIS was a significant predictor of shorter recurrence-free survival (RFS). Lymph node metastasis (P = 0.037) and D-INV (P = 0.008) were independent predictors of shorter disease-specific survival (DSS). The prognostic relevance of the ductal margin status was high, particularly in patients without lymph node metastasis.

Conclusion

The surgical margin status of the bile duct was significantly associated with RFS, DSS, and the recurrence site.

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Title: Relationship between the surgical margin status, prognosis, and recurrence in extrahepatic bile duct cancer patients
Authors: Hiroshi Kurahara
Kosei Maemura
Yuko Mataki
Masahiko Sakoda
Satoshi Iino
Yota Kawasaki
Shinichiro Mori
Yuko Kijima
Shinichi Ueno
Hiroyuki Shinchi
Sonshin Takao
Shoji Natsugoe
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 1/2017
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-016-1491-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between the surgical margin status, prognosis, and recurrence in extrahepatic bile duct cancer patients

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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