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Langenbeck's Archives of Surgery

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Open Access 01-02-2014 | Original Article

Risk of lymph node metastases in multifocal papillary thyroid cancer associated with Hashimoto's thyroiditis

Authors: Aleksander Konturek, Marcin Barczyński, Wojciech Nowak, Wojciech Wierzchowski

Published in: Langenbeck's Archives of Surgery | Issue 2/2014

Abstract

Aims

The aim of this study was to evaluate the risk factors of lymph nodes metastases (LNM) in patients with papillary thyroid cancer (PTC) and coexisting Hashimoto’s thyroiditis (HT).

Patients and methods

This was a retrospective cohort study of patients with PTC and HT who had undergone total thyroidectomy (TT) with central neck dissection (CND) over an 11-year period (between 2002 and 2012). Pathological reports of all eligible patients were reviewed. Multivariable analysis was performed to identify risk factors of LNM.

Results

During the study period, PTC was diagnosed in 130 patients with HT who had undergone TT with CND (F/M ratio = 110:20; median age, 52.4 ± 12.7 years). Multifocal lesions were observed in 28 (21.5 %) patients. LNM were identified in 25 of 28 (89.3 %) patients with multifocal PTC and HT versus 69 of 102 (67.5 %) patients with a solitary focus of PTC and HT (p = 0.023). In multivariable analysis, multifocal disease was identified as an independent risk factor for LNM (odds ratio, 3.99; 95 % confidence interval, 1.12 to 14.15; p = 0.033).

Conclusions

Multifocal PTC in patients with HT is associated with an increased risk of LNM. Nevertheless, the clinical importance of this finding needs to be validated in well-designed prospective studies.

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Title: Risk of lymph node metastases in multifocal papillary thyroid cancer associated with Hashimoto's thyroiditis
Authors: Aleksander Konturek
Marcin Barczyński
Wojciech Nowak
Wojciech Wierzchowski
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 2/2014
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-013-1158-2

At a glance: The STEP trials

Springer Medicine

Risk of lymph node metastases in multifocal papillary thyroid cancer associated with Hashimoto's thyroiditis

Abstract

Aims

Patients and methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Aims

Patients and methods

Results

Conclusions

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