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Langenbeck's Archives of Surgery

Published in:

01-02-2014 | Review Article

Classification of locoregional lymph nodes in medullary and papillary thyroid cancer

Author: T. J. Musholt

Published in: Langenbeck's Archives of Surgery | Issue 2/2014

Abstract

Background

Among the various thyroid malignancies, medullary and papillary thyroid carcinomas are characterized by predominant locoregional lymph node metastases that may cause morbidity and affect patient survival. Although lymph node metastases are frequently detected, the optimal strategy aiming at the removal of all tumor tissues while minimizing the associated surgical morbidity remains a matter of debate.

Purpose

A uniform consented terminology and classification is a precondition in order to compare results of the surgical treatment of thyroid carcinomas. While the broad distinction between central and lateral lymph node groups is generally accepted, the exact boundaries of these neck regions vary significantly in the literature. Four different classification systems are currently used. The classification system of the American Head and Neck Society and the corresponding classification system of the Union for International Cancer Control (UICC) are based on observations of squamous cell carcinomas and appointed to needs of head and neck surgeons. The classification of the Japanese Society for Thyroid Diseases and the compartment classification acknowledge the distinctive pattern of metastasis in thyroid carcinomas.

Conclusions

Comparison of four existing classification systems reveals underlying different treatment concepts. The compartment system meets the necessities of thyroid carcinomas and is used worldwide in studies describing the results of lymph node dissection. Therefore, the German Association of Endocrine Surgery has recommended using the latter system in their recently updated guidelines on thyroid carcinoma.

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Title: Classification of locoregional lymph nodes in medullary and papillary thyroid cancer
Author: T. J. Musholt
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 2/2014
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-013-1146-6

At a glance: The STEP trials

Springer Medicine

Classification of locoregional lymph nodes in medullary and papillary thyroid cancer

Abstract

Background

Purpose

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Purpose

Conclusions

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