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Published in: Langenbeck's Archives of Surgery 8/2013

01-12-2013 | How-I-Do-It article

Isolated caudate lobectomy with pancreatoduodenectomy for a bile duct cancer

Authors: Tsuyoshi Sano, Yasuhiro Shimizu, Yoshiki Senda, Koji Komori, Seiji Ito, Tetsuya Abe, Taira Kinoshita, Yuji Nimura

Published in: Langenbeck's Archives of Surgery | Issue 8/2013

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Abstract

Background

In patients with distal bile duct cancer involving the hepatic hilus, a major hepatectomy concomitant with pancreatoduodenectomy (HPD) is sometimes ideal to obtain a cancer-free resection margin. However, the surgical invasiveness of HPD is considerable.

Patients and methods

We present our treatment option for patients with distal bile duct cancer showing mucosal spreading to the hepatic hilum associated with impaired liver function. To minimize resection volume of the liver, an isolated caudate lobectomy (CL) with pancreatoduodenectomy (PD) using an anterior liver splitting approach is presented. Liver transection lines and bile duct resection points correspond complete with our standard right and left hemihepatectomies with CL for perihilar cholangiocarcinoma.

Results

Total operation time was 765 min, and pedicle occlusion time was 124 min, respectively. Although the proximal mucosal cancer extension was identified at both the right and the left hepatic ducts, all resection margins were negative for cancer.

Conclusions

Isolated CL with PD is an alternative radical treatment option for bile duct cancer patients with impaired liver function.
Literature
1.
go back to reference Seyama Y, Kubota K, Sano K, Noie T, Takayama T, Kosuge T, Makuuchi M (2003) Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate. Ann Surg 238:73–83PubMed Seyama Y, Kubota K, Sano K, Noie T, Takayama T, Kosuge T, Makuuchi M (2003) Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate. Ann Surg 238:73–83PubMed
2.
go back to reference Kawasaki S, Imamura H, Kobayashi A, Noike T, Miwa S, Miyagawa S (2003) Results of surgical resection for patients with hilar bile duct cancer: application of extended hepatectomy after biliary drainage and hemihepatic portal vein embolization. Ann Surg 238:84–92PubMed Kawasaki S, Imamura H, Kobayashi A, Noike T, Miwa S, Miyagawa S (2003) Results of surgical resection for patients with hilar bile duct cancer: application of extended hepatectomy after biliary drainage and hemihepatic portal vein embolization. Ann Surg 238:84–92PubMed
3.
go back to reference Kondo S, Hirano S, Ambo Y, Tanaka E, Okushiba S, Morikawa T, Katoh H (2004) Forty consecutive resections of hilar cholangiocarcinoma with no postoperative mortality and no positive ductal margins: results of a prospective study. Ann Surg 240:95–101PubMedCrossRef Kondo S, Hirano S, Ambo Y, Tanaka E, Okushiba S, Morikawa T, Katoh H (2004) Forty consecutive resections of hilar cholangiocarcinoma with no postoperative mortality and no positive ductal margins: results of a prospective study. Ann Surg 240:95–101PubMedCrossRef
4.
go back to reference Nagino M, Kamiya J, Nishio H, Ebata T, Arai T, Nimura Y (2006) Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up. Ann Surg 243:364–372PubMedCrossRef Nagino M, Kamiya J, Nishio H, Ebata T, Arai T, Nimura Y (2006) Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up. Ann Surg 243:364–372PubMedCrossRef
5.
go back to reference Sano T, Shimada K, Sakamoto Y, Yamamoto J, Yamasaki S, Kosuge T (2006) One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality. Ann Surg 244:240–247PubMedCrossRef Sano T, Shimada K, Sakamoto Y, Yamamoto J, Yamasaki S, Kosuge T (2006) One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality. Ann Surg 244:240–247PubMedCrossRef
6.
go back to reference Nimura Y, Hayakawa N, Kamiya J, Kondo S, Shionoya S (1990) Hepatic segmentectomy with caudate lobe resection for bile duct carcinoma of the hepatic hilus. World J Surg 14:535–544PubMedCrossRef Nimura Y, Hayakawa N, Kamiya J, Kondo S, Shionoya S (1990) Hepatic segmentectomy with caudate lobe resection for bile duct carcinoma of the hepatic hilus. World J Surg 14:535–544PubMedCrossRef
7.
go back to reference Kow AW, Wook CD, Song SC, Kim WS, Kim MJ, Park HJ, Heo JS, Choi SH (2012) Role of caudate lobectomy in type III A and III B hilar cholangiocarcinoma: a15-year experience in a tertiary institution. World J Surg 36:1112–1121PubMedCrossRef Kow AW, Wook CD, Song SC, Kim WS, Kim MJ, Park HJ, Heo JS, Choi SH (2012) Role of caudate lobectomy in type III A and III B hilar cholangiocarcinoma: a15-year experience in a tertiary institution. World J Surg 36:1112–1121PubMedCrossRef
8.
go back to reference Miyazaki M, Kimura F, Shimizu H, Yoshidome H, Otuka M, Kato A, Yoshitomi H, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Takano S (2010) One hundred seven consecutive surgical resections for hilar cholangiocarcinoma of Bismuth types II, III, IV between 2001 and 2008. J Hepatobiliary Pancreat Sci 17:470–475PubMedCrossRef Miyazaki M, Kimura F, Shimizu H, Yoshidome H, Otuka M, Kato A, Yoshitomi H, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Takano S (2010) One hundred seven consecutive surgical resections for hilar cholangiocarcinoma of Bismuth types II, III, IV between 2001 and 2008. J Hepatobiliary Pancreat Sci 17:470–475PubMedCrossRef
9.
go back to reference Unno M, Katayose Y, Rikiyama T, Yoshida H, Yamamoto K, Morikawa T, Hayashi H, Motoi F, Egawa S (2010) Major hepatectomy for perihilar cholangiocarcinoma. J Hepatobiliary Pancreat Sci 17:463–469PubMedCrossRef Unno M, Katayose Y, Rikiyama T, Yoshida H, Yamamoto K, Morikawa T, Hayashi H, Motoi F, Egawa S (2010) Major hepatectomy for perihilar cholangiocarcinoma. J Hepatobiliary Pancreat Sci 17:463–469PubMedCrossRef
10.
go back to reference Young AL, Prasad KR, Toogood GJ, Lodge JP (2010) Surgical treatment of hilar cholangiocarcinoma in a new era: comparison among leading Eastern and Western centers, Leeds. J Hepatobiliary Pancreat Sci 17:497–504PubMedCrossRef Young AL, Prasad KR, Toogood GJ, Lodge JP (2010) Surgical treatment of hilar cholangiocarcinoma in a new era: comparison among leading Eastern and Western centers, Leeds. J Hepatobiliary Pancreat Sci 17:497–504PubMedCrossRef
11.
go back to reference Lee SG, Song GW, Hwang S, Ha TY, Moon DB, Jung DH, Kim KH, Ahn CS, Kim MH, Lee SK, Sung KB, Ko GY (2010) Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experience. J Hepatobiliary Pancreat Sci 17:476–489PubMedCrossRef Lee SG, Song GW, Hwang S, Ha TY, Moon DB, Jung DH, Kim KH, Ahn CS, Kim MH, Lee SK, Sung KB, Ko GY (2010) Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experience. J Hepatobiliary Pancreat Sci 17:476–489PubMedCrossRef
12.
go back to reference Hirano S, Kondo S, Tanaka E, Shichinohe T, Tsuchikawa T, Kato K, Matsumoto J, Kawasaki R (2010) Outcome of surgical treatment of hilar cholangiocarcinoma: a special reference to postoperative morbidity and mortality. J Hepatobiliary Pancreat Sci 17:455–462PubMedCrossRef Hirano S, Kondo S, Tanaka E, Shichinohe T, Tsuchikawa T, Kato K, Matsumoto J, Kawasaki R (2010) Outcome of surgical treatment of hilar cholangiocarcinoma: a special reference to postoperative morbidity and mortality. J Hepatobiliary Pancreat Sci 17:455–462PubMedCrossRef
13.
go back to reference Igami T, Nishio H, Ebata T, Yokkoyama Y, Sugawara G, Nimura Y, Nagino M (2010) Surgical treatment of hilar cholangiocarcinoma in the “new era”: the Nagoya University experience. J Hepatobiliary Pancreat Sci 17:449–454PubMedCrossRef Igami T, Nishio H, Ebata T, Yokkoyama Y, Sugawara G, Nimura Y, Nagino M (2010) Surgical treatment of hilar cholangiocarcinoma in the “new era”: the Nagoya University experience. J Hepatobiliary Pancreat Sci 17:449–454PubMedCrossRef
14.
go back to reference Rocha FG, Matsuo K, Blumgart LH, Jarnagin WR (2010) Hilar cholangiocarcinoma: the Memorial Sloan–Kettering Cancer Center experience. J Hepatobiliary Pancreat Sci 17:490–496PubMedCrossRef Rocha FG, Matsuo K, Blumgart LH, Jarnagin WR (2010) Hilar cholangiocarcinoma: the Memorial Sloan–Kettering Cancer Center experience. J Hepatobiliary Pancreat Sci 17:490–496PubMedCrossRef
15.
go back to reference Neuhaus P, Jonas S, Bechstein WO, Lohmann R, Radke C, Kling N, Wex C, Lobeck H, Hintze R (1999) Extended resections for hilar cholangiocarcinoma. Ann Surg 230:808–818PubMedCrossRef Neuhaus P, Jonas S, Bechstein WO, Lohmann R, Radke C, Kling N, Wex C, Lobeck H, Hintze R (1999) Extended resections for hilar cholangiocarcinoma. Ann Surg 230:808–818PubMedCrossRef
16.
go back to reference Hemming AW, Reed AI, Fujita S, Foley DP, Howard RJ (2005) Surgical management of hilar cholangiocarcinoma. Ann Surg 241:693–702PubMedCrossRef Hemming AW, Reed AI, Fujita S, Foley DP, Howard RJ (2005) Surgical management of hilar cholangiocarcinoma. Ann Surg 241:693–702PubMedCrossRef
17.
go back to reference Miyazaki M, Ito H, Nakagawa K, Ambiru S, Shimizu H, Okaya T, Shinmura K, Nakajima N (1999) Parenchyma-preserving hepatectomy in the surgical treatment of hilar cholangiocarcinoma. J Am Coll Surg 189:575–583PubMedCrossRef Miyazaki M, Ito H, Nakagawa K, Ambiru S, Shimizu H, Okaya T, Shinmura K, Nakajima N (1999) Parenchyma-preserving hepatectomy in the surgical treatment of hilar cholangiocarcinoma. J Am Coll Surg 189:575–583PubMedCrossRef
18.
go back to reference Yamamoto J, Takayama T, Kosuge T, Yoshida J, Shimada K, Yamasaki S, Hasegawa H (1992) An isolated caudate lobectomy by the transhepatic approach for hepatocellular carcinoma in cirrhotic liver. Surgery 111:699–702PubMed Yamamoto J, Takayama T, Kosuge T, Yoshida J, Shimada K, Yamasaki S, Hasegawa H (1992) An isolated caudate lobectomy by the transhepatic approach for hepatocellular carcinoma in cirrhotic liver. Surgery 111:699–702PubMed
19.
go back to reference Takayama T, Tanaka T, Higaki T, Katou K, Teshima Y, Makuuchi M (1994) High dorsal resection of the liver. J Am Coll Surg 179:72–75PubMed Takayama T, Tanaka T, Higaki T, Katou K, Teshima Y, Makuuchi M (1994) High dorsal resection of the liver. J Am Coll Surg 179:72–75PubMed
20.
go back to reference Yamamoto J, Kosuge T, Shimada K, Yamasaki S, Takayama T, Makuuchi M (1999) Anterior transhepatic approach for isolated resection of the caudate lobe of the liver. World J Surg 23:97–101PubMedCrossRef Yamamoto J, Kosuge T, Shimada K, Yamasaki S, Takayama T, Makuuchi M (1999) Anterior transhepatic approach for isolated resection of the caudate lobe of the liver. World J Surg 23:97–101PubMedCrossRef
21.
go back to reference Miyazaki M, Kimura F, Shimizu H, Yoshidome H, Otsuka M, Kato A, Hideyuki Y, Nozawa S, Furukawa K, Mituhashi N, Takeuchi D, Suda K, Takano S (2008) Extensive hilar bile duct resection using a transhepatic approach for patients with hepatic hilar bile duct diseases. Am J Surg 196:125–129PubMedCrossRef Miyazaki M, Kimura F, Shimizu H, Yoshidome H, Otsuka M, Kato A, Hideyuki Y, Nozawa S, Furukawa K, Mituhashi N, Takeuchi D, Suda K, Takano S (2008) Extensive hilar bile duct resection using a transhepatic approach for patients with hepatic hilar bile duct diseases. Am J Surg 196:125–129PubMedCrossRef
22.
go back to reference Nimura Y, Hayakawa N, Kamiya J, Maeda S, Kondo S, Yasui A, Shionoya S (1991) Hepatopancreatoduodenectomy for advanced carcinoma of the biliary tract. Hepatogastroenterology 38:170–175PubMed Nimura Y, Hayakawa N, Kamiya J, Maeda S, Kondo S, Yasui A, Shionoya S (1991) Hepatopancreatoduodenectomy for advanced carcinoma of the biliary tract. Hepatogastroenterology 38:170–175PubMed
23.
go back to reference Ebata T, Nagino M, Nishio H, Arai T, Nimura Y (2007) Right hepatopancreatoduodenectomy: improvements over 23 years to attain acceptability. J Hepatobiliary Pancreat Surg 14:131–135PubMedCrossRef Ebata T, Nagino M, Nishio H, Arai T, Nimura Y (2007) Right hepatopancreatoduodenectomy: improvements over 23 years to attain acceptability. J Hepatobiliary Pancreat Surg 14:131–135PubMedCrossRef
24.
go back to reference Wakai T, Shirai Y, Tsuchiya Y, Nomura T, Akazawa K, Hatakeyama K (2008) Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term results. World J Surg 32:1067–1074PubMedCrossRef Wakai T, Shirai Y, Tsuchiya Y, Nomura T, Akazawa K, Hatakeyama K (2008) Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term results. World J Surg 32:1067–1074PubMedCrossRef
25.
go back to reference Kawakami H, Kuwatani M, Etoh K, Haba S, Yamato H, Shinada K, Nakanishi Y, Tanaka E, Hirano S, Kondo S, Kubota K, Asaka M (2009) Endoscopic retrograde cholangiography versus peroral cholangioscopy to evaluate intraepithelial tumor spread in biliary cancer. Endoscopy 41:959–964PubMedCrossRef Kawakami H, Kuwatani M, Etoh K, Haba S, Yamato H, Shinada K, Nakanishi Y, Tanaka E, Hirano S, Kondo S, Kubota K, Asaka M (2009) Endoscopic retrograde cholangiography versus peroral cholangioscopy to evaluate intraepithelial tumor spread in biliary cancer. Endoscopy 41:959–964PubMedCrossRef
26.
go back to reference Itoi T, Osanai M, Igarashi Y, Tanaka K, Kida M, Maguchi H, Yasuda K, Okano N, Imaizumi H, Yokoyama T, Itokawa F (2010) Diagnostic peroral video cholangioscopy is an accurate diagnostic tool for patients with bile duct lesions. Clin Gastroenterol Hepatol 8:934–938PubMedCrossRef Itoi T, Osanai M, Igarashi Y, Tanaka K, Kida M, Maguchi H, Yasuda K, Okano N, Imaizumi H, Yokoyama T, Itokawa F (2010) Diagnostic peroral video cholangioscopy is an accurate diagnostic tool for patients with bile duct lesions. Clin Gastroenterol Hepatol 8:934–938PubMedCrossRef
27.
go back to reference Nimura Y (1993) Staging of biliary carcinoma: cholangiography and cholangioscopy. Endoscopy 25:76–80PubMedCrossRef Nimura Y (1993) Staging of biliary carcinoma: cholangiography and cholangioscopy. Endoscopy 25:76–80PubMedCrossRef
28.
go back to reference Miyagawa S, Makuuchi M, Kawasaki S, Kakazu T (1995) Criteria for safe hepatic resection. Am J Surg 169:589–594PubMedCrossRef Miyagawa S, Makuuchi M, Kawasaki S, Kakazu T (1995) Criteria for safe hepatic resection. Am J Surg 169:589–594PubMedCrossRef
29.
go back to reference Sobin LH, Gospodarowicz M, Wittekind C (2009) International Union Against Cancer (UICC). TNM classification of malignant tumors, 7th edn. Wiley, New York Sobin LH, Gospodarowicz M, Wittekind C (2009) International Union Against Cancer (UICC). TNM classification of malignant tumors, 7th edn. Wiley, New York
30.
go back to reference Shimada H, Endo I, Sugita M, Masunari H, Fujii Y, Tanaka K, Sekido H, Togo S (2003) Is parenchyma-preserving hepatectomy a noble option in the surgical treatment for high-risk patients with hilar bile duct cancer? Langenbecks Arch Surg 388:33–41PubMed Shimada H, Endo I, Sugita M, Masunari H, Fujii Y, Tanaka K, Sekido H, Togo S (2003) Is parenchyma-preserving hepatectomy a noble option in the surgical treatment for high-risk patients with hilar bile duct cancer? Langenbecks Arch Surg 388:33–41PubMed
31.
go back to reference Sano K, Makuuchi M, Miki K, Maema A, Sugawara Y, Imamura H, Matsunami H, Takayama T (2002) Evaluation of hepatic venous congestion: proposed indication criteria for hepatic vein reconstruction. Ann Surg 236:241–247PubMedCrossRef Sano K, Makuuchi M, Miki K, Maema A, Sugawara Y, Imamura H, Matsunami H, Takayama T (2002) Evaluation of hepatic venous congestion: proposed indication criteria for hepatic vein reconstruction. Ann Surg 236:241–247PubMedCrossRef
32.
go back to reference Bhuiya MR, Nimura Y, Kamiya J, Kondo S, Fukata S, Hayakawa N, Shionoya S (1992) Cinicopathologic studies on perineural invasion of bile duct carcinoma. Ann Surg 215:344–349PubMedCrossRef Bhuiya MR, Nimura Y, Kamiya J, Kondo S, Fukata S, Hayakawa N, Shionoya S (1992) Cinicopathologic studies on perineural invasion of bile duct carcinoma. Ann Surg 215:344–349PubMedCrossRef
33.
go back to reference Klempnauer J, Ridder GJ, von Wasielewski R, Wermer M, Weimann A, Pichlmayr R (1997) Resectional surgery of hilar cholangiocarcinoma: a multivariate analysis of prognostic factors. J Clin Oncol 15:947–954PubMed Klempnauer J, Ridder GJ, von Wasielewski R, Wermer M, Weimann A, Pichlmayr R (1997) Resectional surgery of hilar cholangiocarcinoma: a multivariate analysis of prognostic factors. J Clin Oncol 15:947–954PubMed
34.
go back to reference Sakamoto Y, Shimada K, Nara S, Esaki M, Ojima H, Sano T, Yamamoto J, Kosuge T (2010) Surgical management of infrahilar/suprapancreatic cholangiocarcinoma: an analysis of the surgical procedures, surgical margins, and survivals of 77 patients. J Gastrointest Surg 14:335–343PubMedCrossRef Sakamoto Y, Shimada K, Nara S, Esaki M, Ojima H, Sano T, Yamamoto J, Kosuge T (2010) Surgical management of infrahilar/suprapancreatic cholangiocarcinoma: an analysis of the surgical procedures, surgical margins, and survivals of 77 patients. J Gastrointest Surg 14:335–343PubMedCrossRef
35.
go back to reference Ojima H, Kanai Y, Iwasaki M, Hiraoka N, Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, Sakamoto M, Hirohashi S (2009) Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma. Cancer Sci 100:62–70PubMedCrossRef Ojima H, Kanai Y, Iwasaki M, Hiraoka N, Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, Sakamoto M, Hirohashi S (2009) Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma. Cancer Sci 100:62–70PubMedCrossRef
36.
go back to reference Wakai T, Shirai Y, Moroda T, Yokoyama N, Hatakeyama K (2005) Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma. Cancer 103:1210–1216PubMedCrossRef Wakai T, Shirai Y, Moroda T, Yokoyama N, Hatakeyama K (2005) Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma. Cancer 103:1210–1216PubMedCrossRef
37.
go back to reference Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nimura Y, Nagino M (2012) Hepatopancreatoduodenectomy for cholangiocarcinoma: a single-center review of 85 consecutive patients. Ann Surg 256:297–305PubMedCrossRef Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nimura Y, Nagino M (2012) Hepatopancreatoduodenectomy for cholangiocarcinoma: a single-center review of 85 consecutive patients. Ann Surg 256:297–305PubMedCrossRef
Metadata
Title
Isolated caudate lobectomy with pancreatoduodenectomy for a bile duct cancer
Authors
Tsuyoshi Sano
Yasuhiro Shimizu
Yoshiki Senda
Koji Komori
Seiji Ito
Tetsuya Abe
Taira Kinoshita
Yuji Nimura
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 8/2013
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-013-1110-5

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