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Langenbeck's Archives of Surgery
Published in: Langenbeck's Archives of Surgery 2/2013

01-02-2013 | Original Article

Health-related quality of life after Ivor Lewis esophagectomy

Authors: Christian A. Gutschow, Arnulf H. Hölscher, Jessica Leers, Hans Fuchs, Marc Bludau, Klaus L. Prenzel, E. Bollschweiler, Wolfgang Schröder

Published in: Langenbeck's Archives of Surgery | Issue 2/2013

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Abstract

Purpose

Transthoracic Ivor Lewis esophagectomy is a surgical standard therapy for esophageal carcinoma. The aim of this study was to assess health-related quality of life (HRQL) in mid- and long-term survivors.

Methods

Patients with cancer-free survival of at least 12 months after esophageal resection for cancer were identified from a prospectively maintained database. EORTC questionnaires were sent out to assess health-related general (QLQ-C30) and esophageal cancer-specific (QLQ-OES18) quality of life (QOL). A numeric score was calculated in each conceptual area and compared with reference data.

Results

One hundred forty-seven patients completed the self-rated questionnaires. They were 121 men and 26 women with a mean age of 63.4 (21–83) years; median FU was 39 (12–139) months. Global health status, functional scales, and symptom scores were significantly reduced compared with healthy reference populations. Also, there was no significant impact of tumor histology, neoadjuvant treatment, minimally invasive approach, or duration of follow-up on HRQL. However, more than half of the patients reported a HRQL similar to that of the healthy reference population.

Conclusions

Despite the major psychosocial and physiological impacts of the disease, more than 50 % of mid- and long-term survivors of the Ivor Lewis procedure for esophageal cancer have a HRQL similar to that of the healthy reference population.
Literature
1.
Vallböhmer D, Hölscher AH, DeMeester S et al (2010) A multicenter study of survival after neoadjuvant radiotherapy/chemotherapy and esophagectomy for ypT0N0M0R0 esophageal cancer. Ann Surg 252:744–749PubMedCrossRef
2.
Lagergren P, Avery KN, Hughes R et al (2007) Health-related quality of life among patients cured by surgery for esophageal cancer. Cancer 110:686–693PubMedCrossRef
3.
Viklund P, Lindblad M, Lagergren J (2005) Influence of surgery-related factors on quality of life after esophageal or cardia cancer resection. World J Surg 29:841–848PubMedCrossRef
4.
Gockel I, Gönner U, Domeyer M, Lang H, Junginger Th (2010) Long-term survivors of esophageal cancer: disease-specific quality of life, general health and complications. J Surg Oncol 102:516–522PubMedCrossRef
5.
Lewis I (1946) The surgical treatment of carcinoma of the oesophagus with special reference to a new operation for growths of the middle third. Br J Surg 34:18–31PubMedCrossRef
6.
Hoelscher AH, Schneider PM, Gutschow C, Schröder W (2007) Laparoscopic ischemic conditioning of the stomach for esophageal replacement. Ann Surg 245:241–246CrossRef
7.
Schneider PM, Baldus SE, Metzger R et al (2005) Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer: implications for response classification. Ann Surg 242:684–692PubMedCrossRef
8.
9.
Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European Organisation for Research and Treatment of Cancer QLQ-C 30: a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376PubMedCrossRef
10.
Blazeby JM, Alderson D, Winstone K et al (1996) Development of a EORTC questionnaire module to be used in quality of life assessment for patients with oesophageal cancer. Eur J Cancer 32:1912–1917CrossRef
11.
Blazeby JM, Conroy T, Hammerlid E et al (2003) Clinical and psychometric validation of an EORTC questionnaire module, the EORTC QLQ-OES 18, to assess quality of life in patients with oesophageal cancer. Eur J Cancer 39:1384–1394PubMedCrossRef
12.
Fayers P, Aaronson NK, Bjordal K et al (2001) EORTC QLQ-C 30 scoring manual, 3rd edn. European Organisation for Research and Treatment of Cancer, Brussels
13.
Fayers PM, Machin D (2007) Quality of life: assessment, analysis and interpretation. Wiley, Chichester
14.
Parameswaran R, Blazeby JM, Hughes R, Mitchell K, Berrisford RG, Wajed SA (2010) Health-related quality of life after minimally invasive oesophagectomy. Br J Surg 97:525–531PubMedCrossRef
15.
Gutschow CA, Schröder W, Hölscher AH (1998) Funktion des Ersatzorgans nach Ösophagektomie. Chir Gastroenterol 14:300–306CrossRef
16.
Gutschow C, Collard JM, Sallizoni M, Romagnoli R, Hoelscher AH (2001) Denervated stomach as an esophageal substitute recovers intraluminal acidity with time. Ann Surg 233:509–514PubMedCrossRef
17.
Rutegard M, Lagergren J, Rouvelas I et al (2008) Population-based study of surgical factors in relation to health-related quality of life after oesophageal cancer resection. Br J Surg 95:592–601PubMedCrossRef
18.
Rutegard M, Lagergren P (2008) No influence of surgical volume on patients' health-related quality of life after esophageal cancer resection. Ann Surg Oncol 15:2380–2387PubMedCrossRef
19.
Blazeby JM, Williams MH, Brookes ST et al (1995) Quality of life measurement in patients with oesophageal cancer. Gut 37:505–508PubMedCrossRef
20.
Blazeby JM, Metcalfe C, Nicklin J et al (2005) Association between quality of life scores and short-term outcome after surgery for cancer of the oesophagus or gastric cardia. Br J Surg 92:1502–1507PubMedCrossRef
21.
Blazeby JM, Farndon JR, Donovan J et al (2000) A prospective longitudinal study examining the quality of life of patients with esophageal carcinoma. Cancer 88:1781–1787PubMedCrossRef
22.
McLarty AJ, Deschamps C, Trastek VF et al (1997) Esophageal resection for cancer of the esophagus: long-term function and quality of life. Ann Thorac Surg 63:1568–1572PubMedCrossRef
23.
de Boer AG, Genovesi PI, Sprangers MA et al (2000) Quality of life in long-term survivors after curative transhiatal oesophagectomy for oesophageal carcinoma. Br J Surg 87:1716–1721PubMedCrossRef
24.
Deschamps C, Nichols FC III, Cassivi SD et al (2005) Long-term function and quality of life after esophageal resection for cancer and Barrett's. Surg Clin North Am 85:649–656PubMedCrossRef
25.
Moraca RJ, Low DE (2006) Outcomes and health-related quality of life after esophagectomy for high-grade dysplasia and intramucosal cancer. Arch Surg 141:545–549PubMedCrossRef
26.
Djärv T, Lagergren J, Blazeby JM et al (2008) Long-term health related quality of life following surgery for oesophageal cancer. Br J Surg 95:1121–1126PubMedCrossRef
27.
Donohoe CL, McGillycuddy E, Reynolds JV (2011) Long-term health-related quality of life for disease-free esophageal cancer patients. World J Surg 35:1853–1860PubMedCrossRef
28.
Derogar M, Lagergren P (2012) Health-related quality of life among 5-year survivors of esophageal cancer surgery: a prospective population-based study. J Clin Oncol 30:413–418PubMedCrossRef
29.
Pech O, Bollschweiler E, Manner H, Leers J, Ell C, Hoelscher AH (2011) Comparison between endoscopic and surgical resection of mucosal esophageal adenocarcinoma in Barrett's esophagus at two high-volume centers. Ann Surg 254:67–72PubMedCrossRef
30.
Rosmolen WD, Boer KR, de Leeuw RJR et al (2010) Quality of life and fear of cancer recurrence after endoscopic and surgical treatment for early neoplasia in Barrett's esophagus. Endoscopy 42:525–531PubMedCrossRef
31.
Reynolds JV, McLaughlin R, Moore J, Rowley S, Ravi N, Byrne PJ (2006) Prospective evaluation of quality of life in patients with localized oesophageal cancer treated by multimodality therapy or surgery alone. Br J Surg 93:1084–1090PubMedCrossRef
32.
Blazeby JM, Sanford E, Falk SJ, Alderson D, Donovan JL (2005) Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal cancer. Cancer 103:1791–1799PubMedCrossRef
33.
Luketich JD, Alvelo-Rivera M, Buenaventura PO et al (2003) Minimally invasive esophagectomy: outcomes in 222 patients. Ann Surg 238:486–494PubMed
34.
Koeda K, Nishizuka S, Wakabayashi G (2011) Minimally invasive surgery for gastric cancer: the future standard of care. World J Surg 35:1469–1477PubMedCrossRef
Metadata
Title
Health-related quality of life after Ivor Lewis esophagectomy
Authors
Christian A. Gutschow
Arnulf H. Hölscher
Jessica Leers
Hans Fuchs
Marc Bludau
Klaus L. Prenzel
E. Bollschweiler
Wolfgang Schröder
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Langenbeck's Archives of Surgery / Issue 2/2013
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-012-0960-6

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