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Langenbeck's Archives of Surgery

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01-01-2012 | Review Article

Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations

Authors: Jochen Maul, Martin Zeitz

Published in: Langenbeck's Archives of Surgery | Issue 1/2012

Abstract

Background

Ulcerative colitis (UC) is a complex disease in which the interaction of genetic, environmental and microbial factors drives chronic intestinal inflammation that finally leads to extensive tissue fibrosis.

Discussion

The present review discusses the current knowledge on genetic susceptibility, especially of the IL-12/IL-23 pathway, the pathophysiologic role of the involved cytokines (e.g. IL-13, IL-23, TGFβ1) and immune cells (e.g. T cells, epithelial cells, fibroblasts) in UC followed by an overview on actual therapeutic considerations. These future therapies will target selectively the involved cell types by blocking their activation and its downstream signalling, by inhibiting their migration to the inflamed site and by anti-cytokine strategies. This may avoid–when initiated in time–the perpetuation of the inflammatory mechanisms thus preventing fibrosis. With respect to animal models that have guided the most productive efforts for understanding human inflammatory bowel disease, these will be shortly discussed in the respective context.

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Title: Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations
Authors: Jochen Maul
Martin Zeitz
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 1/2012
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-011-0789-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations

Abstract

Background

Discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Discussion

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Perioperative infliximab application has marginal effects on ischemia–reperfusion injury in experimental small bowel transplantation in rats

Letter to the editor regarding the experimental study of Adas et al.: Mesenchymal stem cells improve the healing of ischemic colonic anastomoses

Multivisceral and standard resections in colorectal cancer

Surgical management of ulcerative colitis