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Langenbeck's Archives of Surgery

Published in:

01-01-2011 | Review Article

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

Authors: Brigitte Vollmar, Michael D. Menger

Published in: Langenbeck's Archives of Surgery | Issue 1/2011

Abstract

Background

Intestinal ischemia and reperfusion (I/R) is a challenging and life-threatening clinical problem with diverse causes. The delay in diagnosis and treatment contributes to the continued high in-hospital mortality rate.

Results

Experimental research during the last decades could demonstrate that microcirculatory dysfunctions are determinants for the manifestation and propagation of intestinal I/R injury. Key features are nutritive perfusion failure, inflammatory cell response, mediator surge and breakdown of the epithelial barrier function with bacterial translocation, and development of a systemic inflammatory response. This review provides novel insight into the basic mechanisms of damaged intestinal microcirculation and covers therapeutic targets to attenuate intestinal I/R injury.

Conclusion

The opportunity now exists to apply this insight into the translation of experimental data to clinical trial-based research. Understanding the basic events triggered by intestinal I/R may offer new diagnostic and therapeutic options in order to achieve improved outcome of patients with intestinal I/R injury.

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Title: Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences
Authors: Brigitte Vollmar
Michael D. Menger
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 1/2011
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-010-0727-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

Abstract

Background

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Results

Conclusion

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