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01-09-2009 | Original Article

The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study

Authors: Mario Testini, Rinaldo Marzaioli, Germana Lissidini, Agostino Lippolis, Francesco Logoluso, Angela Gurrado, Domenica Lardo, Elisabetta Poli, Giuseppe Piccinni

Published in: Langenbeck's Archives of Surgery | Issue 5/2009

Abstract

Background

The objective of this study was to compare the effectiveness of FloSeal® matrix hemostatic agent with hemostatic surgical procedures and Tabotamp® in thyroid surgery.

Methods

One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5 × 5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations.

Results

Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p = 0.02) and vs. Tabotamp (122 min, p = 0.0003). Also, wound drain removal occurred earlier with FloSeal (p = 0.006 vs. surgical; p = 0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p = 0.02 vs. surgical; p = 0.002 vs. Tabotamp).

Conclusions

FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.

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Title: The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study
Authors: Mario Testini
Rinaldo Marzaioli
Germana Lissidini
Agostino Lippolis
Francesco Logoluso
Angela Gurrado
Domenica Lardo
Elisabetta Poli
Giuseppe Piccinni
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 5/2009
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-009-0497-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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