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Langenbeck's Archives of Surgery

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01-06-2010 | Original Article

Expression and regulation of hedgehog signaling pathway in pancreatic cancer

Authors: Yinmo Yang, Xiaodong Tian, Xuehai Xie, Yan Zhuang, Wenhan Wu, Weimin Wang

Published in: Langenbeck's Archives of Surgery | Issue 5/2010

Abstract

Introduction

Pancreatic cancer is an aggressive malignancy with a poor prognosis. The overall 5-year survival rate of pancreatic cancer is less than 5%, and has not improved significantly for years. Further understanding of the molecular carcinogenesis of pancreatic cancer is critical for designing effective ways to treat this type of malignancy.

Methods

In this study, we examine expression of hedgehog signaling molecules in 54 surgically removed pancreatic cancer specimens as well as seven available pancreatic cancer cell lines.

Results

We find that expression of Ptch is associated with tumor size, tumor differentiation, lymph node metastasis, and clinical stages, whereas expression of Smo is associated with tumor differentiation and lymph node metastasis. Our studies from pancreatic cancer cell lines indicate that targeted inhibition of hedgehog signaling by Smo signaling inhibitor KAAD-cyclopamine causes hedgehog target gene expression (Gli1) suppression, induces P21 expression and G1 cell population, and reduced expression of Cyclin D1 and IGF2.

Conclusions

These results indicate that hedgehog signaling activation is a very common event in pancreatic cancer and that targeted inhibition of hedgehog signaling may be effective in treatment of pancreatic cancer.

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Title: Expression and regulation of hedgehog signaling pathway in pancreatic cancer
Authors: Yinmo Yang
Xiaodong Tian
Xuehai Xie
Yan Zhuang
Wenhan Wu
Weimin Wang
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 5/2010
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-009-0493-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Expression and regulation of hedgehog signaling pathway in pancreatic cancer

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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