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Published in: Langenbeck's Archives of Surgery 4/2009

01-07-2009 | Original Article

Does tumor size have an impact on gastric cancer? A single institute experience

Authors: Kyong Hwa Jun, Hun Jung, Jong Min Baek, Hyung Min Chin, Woo Bae Park

Published in: Langenbeck's Archives of Surgery | Issue 4/2009

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Abstract

Purpose

The present study investigated the prognostic significance of tumor size in gastric carcinoma patients.

Methods

Nine hundred seventy-three gastric carcinoma patients who underwent curative gastrectomy were included and hospital records were reviewed to determine the relationship between tumor size and survival.

Results

First, the patients were divided based on the mean value of the tumor size in respective stages to control selection bias. Only in stages I and III was tumor size a significant independent prognostic factor. Second, we analyzed the appropriate cutoff value for the large tumor. The minimum criterion for a large tumor, which was determined by the receiver-operating characteristic curve for cancer-related death, was 3.5 cm. There were significant differences between patients with large and small tumors with respect to depth of invasion, number of lymph node metastasis, and stage of disease.

Conclusions

Tumor size serves as an indicator of prognosis in gastric cancer patients and a tumor size of 3.5 cm can be used as a significant lower limit of standard size criterion.
Literature
1.
go back to reference Moriguchi S, Maehara Y, Korenaga D et al (1992) Prediction of survival time after curative surgery for advanced gastric cancer. Eur J Surg Oncol 18:287–292PubMed Moriguchi S, Maehara Y, Korenaga D et al (1992) Prediction of survival time after curative surgery for advanced gastric cancer. Eur J Surg Oncol 18:287–292PubMed
5.
go back to reference Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma—2nd English edition. Gastric Cancer 1:10–24PubMedCrossRef Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma—2nd English edition. Gastric Cancer 1:10–24PubMedCrossRef
6.
go back to reference Sobin LH, Wittekind C (2002) UICC/AJCC TNM classification of malignant tumors, 6th edn. Wiley-Liss, New York Sobin LH, Wittekind C (2002) UICC/AJCC TNM classification of malignant tumors, 6th edn. Wiley-Liss, New York
7.
go back to reference Japanese Research Society for Gastric Carcinoma (1995) Microscopic findings. In: Nishi M, Omori Y (eds) Japanese classification of gastric carcinoma. Kanehara, Tokyo, pp 3–13 Japanese Research Society for Gastric Carcinoma (1995) Microscopic findings. In: Nishi M, Omori Y (eds) Japanese classification of gastric carcinoma. Kanehara, Tokyo, pp 3–13
8.
go back to reference Yokota T, Ishiyama S, Saito T et al (2002) Is tumor size a prognostic indicator for gastric carcinoma? Anticancer Res 22:3673–3677PubMed Yokota T, Ishiyama S, Saito T et al (2002) Is tumor size a prognostic indicator for gastric carcinoma? Anticancer Res 22:3673–3677PubMed
10.
go back to reference Yasui A, Hirase Y, Miyake M et al (1973) Pathology of superficial spreading type of gastreic cancer. To Cho 8:1305–1310 Yasui A, Hirase Y, Miyake M et al (1973) Pathology of superficial spreading type of gastreic cancer. To Cho 8:1305–1310
12.
go back to reference Kitamura K, Yamaguchi T, Okamoto K et al (1996) Superficial spreading type of early gastric cancer. Br J Cancer 74:1834–1837PubMed Kitamura K, Yamaguchi T, Okamoto K et al (1996) Superficial spreading type of early gastric cancer. Br J Cancer 74:1834–1837PubMed
14.
go back to reference Maehara Y, Oiwa H, Sakaguchi Y et al (1995) Surgical treatment and prognosis for patients with gastric cancer lesions larger than ten centimeters in size. Oncology 52:35–40PubMedCrossRef Maehara Y, Oiwa H, Sakaguchi Y et al (1995) Surgical treatment and prognosis for patients with gastric cancer lesions larger than ten centimeters in size. Oncology 52:35–40PubMedCrossRef
18.
go back to reference Yoshikawa T, Tsuburaya A, Kobayashi O et al (2001) Should scirrhous gastric carcinoma be treated surgically? Clinical experiences with 233 cases and a retrospective analysis of prognosticators. Hepatogastroenterology 48:1509–1512PubMed Yoshikawa T, Tsuburaya A, Kobayashi O et al (2001) Should scirrhous gastric carcinoma be treated surgically? Clinical experiences with 233 cases and a retrospective analysis of prognosticators. Hepatogastroenterology 48:1509–1512PubMed
19.
go back to reference Nashimoto A, Nakajima T, Furukawa H et al (2003) Randomized trial of adjuvant chemotherapy with mitomycin, fluorouracil, and cytosine arabinoside followed by oral fluorouracil in serosa-negative gastric cancer: Japan Clinical Oncology Group 9206-1. J Clin Oncol 21:2282–2287, doi:10.1200/JCO.2003.06.103 PubMedCrossRef Nashimoto A, Nakajima T, Furukawa H et al (2003) Randomized trial of adjuvant chemotherapy with mitomycin, fluorouracil, and cytosine arabinoside followed by oral fluorouracil in serosa-negative gastric cancer: Japan Clinical Oncology Group 9206-1. J Clin Oncol 21:2282–2287, doi:10.​1200/​JCO.​2003.​06.​103 PubMedCrossRef
Metadata
Title
Does tumor size have an impact on gastric cancer? A single institute experience
Authors
Kyong Hwa Jun
Hun Jung
Jong Min Baek
Hyung Min Chin
Woo Bae Park
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
Langenbeck's Archives of Surgery / Issue 4/2009
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-008-0417-0

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