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Langenbeck's Archives of Surgery

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01-02-2004 | Original Article

Treatment of advanced rectal cancer in a patient after combined pancreas–kidney transplantation

Authors: T. T. Zittel, C. F. R. Mehl, U. Reichmann, H. D. Becker, E. C. Jehle

Published in: Langenbeck's Archives of Surgery | Issue 1/2004

Abstract

Background

Organ transplantation is a standard procedure today. Due to immunosuppressive drugs and increasing survival after organ transplantation, patients with transplanted organs carry an increased risk of developing malignant tumours. Accordingly, more patients with malignant tumours after transplantation will be faced by general or oncology surgeons. We report the case of a 48-year-old patient with advanced rectal cancer 6.5 years after pancreas–kidney-transplantation for type I diabetes.

Method

The patient was treated with neo-adjuvant radio-chemotherapy, followed by low anterior rectal resection with total mesorectal excision. Consecutively, a solitary hepatic metastasis, a solitary pulmonary metastasis and a chest wall metastasis were resected over the course of 13 months.

Result

The patient eventually died of metastasized cancer 32 months after therapy had been initiated, his organ grafts functioning well until his death.

Conclusion

Our case report provides evidence that transplantation patients should receive standard oncology treatment, including neo-adjuvant treatment, so long as their general condition and organ graft functions allow us to do so, although a higher degree of morbidity might be encountered.

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Title: Treatment of advanced rectal cancer in a patient after combined pancreas–kidney transplantation
Authors: T. T. Zittel
C. F. R. Mehl
U. Reichmann
H. D. Becker
E. C. Jehle
Publication date: 01-02-2004
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 1/2004
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-003-0422-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Treatment of advanced rectal cancer in a patient after combined pancreas–kidney transplantation

Abstract

Background

Method

Result

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Method

Result

Conclusion

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