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05-03-2024 | Original Article

Effect of blood flow restriction and electrical muscle stimulation on human glycemic response to a glucose challenge

Authors: Alexa A. Robertson, Christopher Pignanelli, Jamie F. Burr

Published in: European Journal of Applied Physiology

Abstract

Purpose

To determine whether reduced tissue oxygen availability through blood flow restriction (BFR) alone, or in combination with electrically induced muscle contractions, can improve glucose clearance after an acute glucose challenge.

Methods

In a randomized crossover design, 21 young participants (females: 12) were allocated to perform 1) electrical muscle stimulation (EMS), 2) BFR, 3) EMS + BFR or 4) no treatment (control). Participants completed each condition immediately preceding a 2 h oral glucose tolerance test (100 g). Primary analyses were performed on the glucose area under the curve (AUC) at time points 0–30, 30–120, and 0–120 min. Secondary analyses were performed on glycemic responses based on biological sex and estimated muscle phenotype.

Results

Compared to the control (322±25 mM∙min), the 0-30 min AUC was reduced following EMS (293±22 mM∙min, p = 0.0004), and EMS + BFR (298±36 mM∙min., p = 0.006), whereas BFR in isolation did not differ (306±30 mM∙min, p = 0.1). The 30–120 and 0-120 min glucose AUCs were similar across conditions. Based on effect size from the control conditions, our secondary analysis suggests different 0–30 min glycemic responses after EMS + BFR between females (d_z = 0.206) vs. males (d_z = 1.461) and/or slow (d_z = 0.426) vs. fast (d_z = 1.075) muscle phenotype.

Conclusion

Reducing tissue oxygen availability with BFR did not augment the effects of EMS in the overall group; however, we provide preliminary data to suggest possible sex and/or muscle phenotypic responses in glycemic regulation with these modalities.

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Title: Effect of blood flow restriction and electrical muscle stimulation on human glycemic response to a glucose challenge
Authors: Alexa A. Robertson
Christopher Pignanelli
Jamie F. Burr
Publication date: 05-03-2024
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-024-05444-z

At a glance: The STEP trials

Springer Medicine

Effect of blood flow restriction and electrical muscle stimulation on human glycemic response to a glucose challenge

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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