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European Journal of Applied Physiology

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01-06-2020 | Original Article

Interchangeability between two breath-by-breath O₂ uptake calculation algorithms in asthmatic and healthy volunteers

Authors: Maria Pia Francescato, Mario Canciani, Valentina Cettolo

Published in: European Journal of Applied Physiology | Issue 6/2020

Abstract

Introduction

The interchangeability analysis has been recently proposed to objectively assess whether a newly developed measurement tool can substitute the older ones; this analysis assumes that the measures yielded by the compared tools should differ less than a maximum acceptable value. We aimed to assess the interchangeability rate (IR) of the breath-by-breath O₂ uptake data calculated with the “Independent breath” (IND) and the “Expiration-only” (EXP) algorithms.

Methods

Oxygen, carbon dioxide fractions, and ventilatory flow were recorded continuously over 26 min in 18 asthmatic and 20 well-matched healthy volunteers at rest, during cycling, and recovery; oxygen uptake (V’O₂) was calculated with the two algorithms under comparison. Coefficients of variation (CVs) of all the steady-state condition were modeled as a function of the average V’O₂ values and IR was calculated accordingly.

Results

CVs were significantly greater in the asthmatic volunteers (F = 5.97, p < 0.05), being lower for IND compared to EXP (F > 7.04, p < 0.02). CVs decreased as a function of the reciprocal of the square root of the average V’O₂. The IR, calculated on the basis of this relationship, was not significantly different in the two groups of volunteers (F = 0.77, p = 0.385); taking as reference method the IND, or EXP algorithms, the IR values were significantly different (F = 58.6, p < 0.001), amounting to 97.4 ± 2.2% or to 98.2 ± 1.7%, respectively.

Conclusion

The relative noise of V’O₂ was greater in the asthmatic volunteers compared to the healthy ones and was lower for IND compared to EXP. The interchangeability analysis suggested that IND might be a better substitute for EXP than the opposite.

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Title: Interchangeability between two breath-by-breath O2 uptake calculation algorithms in asthmatic and healthy volunteers
Authors: Maria Pia Francescato
Mario Canciani
Valentina Cettolo
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 6/2020
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-020-04374-w

At a glance: The STEP trials

Springer Medicine

Interchangeability between two breath-by-breath O₂ uptake calculation algorithms in asthmatic and healthy volunteers

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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