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01-06-2020 | Erythropoietin | Original Article

No effect of supplemented heat stress during an acute endurance exercise session in hypoxia on hepcidin regulation

Authors: Nanako Hayashi, Haruka Yatsutani, Hisashi Mori, Hiroto Ito, Claire E. Badenhorst, Kazushige Goto

Published in: European Journal of Applied Physiology | Issue 6/2020

Abstract

Hepcidin is a novel factor for iron deficiency in athletes, which is suggested to be regulated by interleukin-6 (IL-6) or erythropoietin (EPO).

Purpose

The purpose of the present study was to compare endurance exercise-induced hepcidin elevation among “normoxia”, “hypoxia” and “combined heat and hypoxia”.

Methods

Twelve males (21.5 ± 0.3 years, 168.1 ± 1.2 cm, 63.6 ± 2.0 kg) participated in the present study. They performed 60 min of cycling at 60% of \({\dot{\text{V}}}{\text{O}}_{2{\text{max}}}\) in either “heat and hypoxia” (HHYP; F_iO₂ 14.5%, 32 °C), “hypoxia” (HYP; F_iO₂ 14.5%, 23 °C) or “normoxia” (NOR; F_iO₂ 20.9%, 23 °C). After completing the exercise, participants remained in the prescribed conditions for 3 h post-exercise. Blood samples were collected before, immediately and 3 h after exercise.

Results

Plasma IL-6 level significantly increased immediately after exercise (P < 0.05), with no significant difference among the trials. A significant elevation in serum EPO was observed 3 h after exercise in hypoxic trials (HHYP and HYP, P < 0.05), with no significant difference between HHYP and HYP. Serum hepcidin level increased 3 h after exercise in all trials (NOR, before 18.3 ± 3.9 and post180 31.2 ± 6.3 ng/mL; HYP, before 13.5 ± 2.5 and post180 23.3 ± 3.6 ng/mL, HHYP; before 15.8 ± 3.3 and post180 31.4 ± 5.3 ng/mL, P < 0.05). However, there was no significant difference among the trials during post-exercise.

Conclusion

Endurance exercise in “combined heat and hypoxia” did not exacerbate exercise-induced hepcidin elevation compared with the same exercise in “hypoxia” or “normoxia”.

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Title: No effect of supplemented heat stress during an acute endurance exercise session in hypoxia on hepcidin regulation
Authors: Nanako Hayashi
Haruka Yatsutani
Hisashi Mori
Hiroto Ito
Claire E. Badenhorst
Kazushige Goto
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Erythropoietin
Erythropoietin
Iron Deficiency
Epoetin alfa
Published in: European Journal of Applied Physiology / Issue 6/2020
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-020-04365-x

ACC 2024 Congress

Springer Medicine

No effect of supplemented heat stress during an acute endurance exercise session in hypoxia on hepcidin regulation

Abstract

Purpose

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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