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European Journal of Applied Physiology

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Open Access 01-12-2019 | Erythropoietin | Original Article

Erythropoietic responses to a series of repeated maximal dynamic and static apnoeas in elite and non-breath-hold divers

Authors: Antonis Elia, Matthew J. Barlow, Kevin Deighton, Oliver J. Wilson, John P. O’Hara

Published in: European Journal of Applied Physiology | Issue 11-12/2019

Abstract

Purpose

Serum erythropoietin (EPO) concentration is increased following static apnoea-induced hypoxia. However, the acute erythropoietic responses to a series of dynamic apnoeas in non-divers (ND) or elite breath-hold divers (EBHD) are unknown.

Methods

Participants were stratified into EBHD (n = 8), ND (n = 10) and control (n = 8) groups. On two separate occasions, EBHD and ND performed a series of five maximal dynamic apnoeas (DYN) or two sets of five maximal static apnoeas (STA). Control performed a static eupnoeic (STE) protocol to control against any effects of water immersion and diurnal variation on EPO. Peripheral oxygen saturation (SpO₂) levels were monitored up to 30 s post each maximal effort. Blood samples were collected at 30, 90, and 180 min after each protocol for EPO, haemoglobin and haematocrit concentrations.

Results

No between group differences were observed at baseline (p > 0.05). For EBHD and ND, mean end-apnoea SpO₂ was lower in DYN (EBHD, 62 ± 10%, p = 0.024; ND, 85 ± 6%; p = 0.020) than STA (EBHD, 76 ± 7%; ND, 96 ± 1%) and control (98 ± 1%) protocols. EBHD attained lower end-apnoeic SpO₂ during DYN and STA than ND (p < 0.001). Serum EPO increased from baseline following the DYN protocol in EBHD only (EBHD, p < 0.001; ND, p = 0.622). EBHD EPO increased from baseline (6.85 ± 0.9mlU/mL) by 60% at 30 min (10.82 ± 2.5mlU/mL, p = 0.017) and 63% at 180 min (10.87 ± 2.1mlU/mL, p = 0.024). Serum EPO did not change after the STA (EBHD, p = 0.534; ND, p = 0.850) and STE (p = 0.056) protocols. There was a significant negative correlation (r = − 0.49, p = 0.003) between end-apnoeic SpO₂ and peak post-apnoeic serum EPO concentrations.

Conclusions

The novel findings demonstrate that circulating EPO is only increased after DYN in EBHD. This may relate to the greater hypoxemia achieved by EBHD during the DYN.

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Title: Erythropoietic responses to a series of repeated maximal dynamic and static apnoeas in elite and non-breath-hold divers
Authors: Antonis Elia
Matthew J. Barlow
Kevin Deighton
Oliver J. Wilson
John P. O’Hara
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Erythropoietin
Erythropoietin
Epoetin alfa
Published in: European Journal of Applied Physiology / Issue 11-12/2019
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-019-04235-1

At a glance: The STEP trials

Springer Medicine

Erythropoietic responses to a series of repeated maximal dynamic and static apnoeas in elite and non-breath-hold divers

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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