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01-10-2018 | Original Article

Prolonged standing increases lower limb arterial stiffness

Authors: Aaron R. Caldwell, Kaitlin M. Gallagher, Benjamin T. Harris, Megan E. Rosa-Caldwell, Marcus Payne, Bryce Daniels, Matthew S. Ganio

Published in: European Journal of Applied Physiology | Issue 10/2018

Abstract

Purpose

Standing workstations have recently been promoted as a healthy alternative to sitting. However, it is unknown how prolonged standing affects arterial stiffness, a prognostic indicator of cardiovascular health. The purpose of this study was twofold: to observe changes in arterial stiffness, as assessed by pulse wave velocity (PWV), with a 2-h bout of standing, and to determine if short, intermittent walking bouts provide a comparative advantage to standing alone.

Methods

Nineteen adults had arterial stiffness assessed by pulse wave velocity. Central (C_PWV), upper peripheral (U_PWV), and lower peripheral (L_PWV) PWV were assessed before (supine), during standing (min 10, 60, and 120), and after (supine) the 2-h standing bout. In one trial, the participants stood at a standing desk immobile for 2 h. In the other trial, participants performed 5-min walking breaks after every 25 min of standing.

Results

After 2-h of standing, supine (85.8 ± 90.1 cm/s) and standing (303.4 ± 390.2 cm/s), L_PWV increased independent of trial (i.e., main effect of time; p < 0.001). Walking breaks during 2 h of standing did not significantly attenuate these changes. In addition, standing C_PWV decreased over time (− 38.5 ± 61.5 cm/s; p = 0.04). Yet, U_PWV, standing or supine, did not change over the course of standing (p > 0.05).

Conclusions

These findings indicate that prolonged standing increases the measures of arterial stiffness and there is no evidence that walk breaks attenuate this response.

Agarwal S, Steinmaus C, Harris-Adamson C (2018) Sit-stand workstations and impact on low back discomfort: a systematic review and meta-analysis. Ergonomics 61(4):538–552. https://doi.org/10.1080/00140139.2017.1402960 CrossRefPubMed

Ashor AW, Lara J, Siervo M et al (2014) Effects of exercise modalities on arterial stiffness and wave reflection: a systematic review and meta-analysis of randomized controlled trials. PLoS ONE 9:e110034. https://doi.org/10.1371/journal.pone.0110034 CrossRefPubMedPubMedCentral

Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB (2014) Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol 63(7):636–646. https://doi.org/10.1016/j.jacc.2013.09.063 CrossRefPubMed

Brothers RM, Wingo JE, Hubing KA, Del Coso J, Crandall CG (2009) Effect of whole body heat stress on peripheral vasoconstriction during leg dependency. J Appl Physiol 107(6):1704–1709. https://doi.org/10.1152/japplphysiol.00711.2009 CrossRefPubMedPubMedCentral

Calabia J, Torguet P, Garcia M, Garcia I, Martin N, Guasch B, Faur D, Valles M (2011) Doppler ultrasound in the measurement of pulse wave velocity: agreement with the Complior method. Cardiovasc Ultrasound 9:13. https://doi.org/10.1186/1476-7120-9-13 CrossRefPubMedPubMedCentral

Graves EF, Shepherd RCM, Cabot SO, Hopkins J ND (2015) Evaluation of sit-stand workstations in an office setting: a randomised controlled trial. BMC Public Health 15:1145. https://doi.org/10.1186/s12889-015-2469-8 CrossRef

Healy GN, Winkler EAH, Eakin EG, Owen N, Lamontagne AD, Moodie M, Dunstan DW (2017) A cluster RCT to reduce workers’ sitting time: impact on cardiometabolic biomarkers. Med Sci Sports Exerc 49(10):2032–2039. https://doi.org/10.1249/MSS.0000000000001328 CrossRefPubMed

Heffernan KS, Jae SY, Echols GH et al (2007) Arterial stiffness and wave reflection following exercise in resistance-trained men. Med Sci Sports Exerc 39:842–848. https://doi.org/10.1249/mss.0b013e318031b03c CrossRefPubMed

Henriksen O (1977) Local sympathetic reflex mechanism in regulation of blood flow in human subcutaneous adipose tissue. Acta Physiol Scand Suppl 450:1–48PubMed

John D, Lyden K, Bassett DR (2015) A physiological perspective on treadmill and sit-to-stand workstations. Ergon Design 23(3):14–19CrossRef

Kingwell BA, Berry KL, Cameron JD, Jennings GL, Dart AM (1997) Arterial compliance increases after moderate-intensity cycling. Am J Physiol 273(5 Pt 2):H2186–H2191PubMed

Krause N, Lynch JW, Kaplan GA, Cohen RD, Salonen R, Salonen JT (2000) Standing at work and progression of carotid atherosclerosis. Scand J Work Environ Health 26(3):227–236CrossRefPubMed

Kroger K, Kucharczik A, Hirche H, Rudofsky G (1999) Atherosclerotic lesions are more frequent in femoral arteries than in carotid arteries independent of increasing number of risk factors. Angiology 50(8):649–654. https://doi.org/10.1177/000331979905000805 CrossRefPubMed

Kulinski JP, Sanghavi M, Ayers CR, Das SR, Banerjee S, Berry JD, Addo T, De Lemos JA, Kumbhani DJ (2015) Association between low ankle–brachial index and accelerometer-derived sedentary and exercise time in the asymptomatic general population. Vasc Med 20(4):332–338. https://doi.org/10.1177/1358863X15573837 CrossRefPubMed

Lakens D (2013) Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol 4:863. https://doi.org/10.3389/fpsyg.2013.00863 CrossRefPubMedPubMedCentral

Li LX, Wu X, Lu JX, Tu YF, Yu LB, Li MF, Zhang WX, Zhu JA, Yuan GY, Bao YQ, Jia WP (2014) Comparison of carotid and lower limb atherosclerotic lesions in both previously known and newly diagnosed type 2 diabetes mellitus. J Diabetes Investig 5(6):734–742. https://doi.org/10.1111/jdi.12204 CrossRefPubMedPubMedCentral

Lopez-Jimenez F (2015) Standing for healthier lives—literally. Eur Heart J 36:2650–2652CrossRefPubMed

McDermott MM (2006) The magnitude of the problem of peripheral arterial disease: epidemiology and clinical significance. Clevel Clin J Med 73(Suppl 4):S2–S7CrossRef

Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, Vita JA, Levy D, Benjamin EJ (2010) Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation 121(4):505–511. https://doi.org/10.1161/CIRCULATIONAHA.109.886655 CrossRefPubMedPubMedCentral

Morishima T, Restaino RM, Walsh LK, Kanaley JA, Fadel PJ, Padilla J (2016) Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol 311(1):H177–H182. https://doi.org/10.1152/ajpheart.00297.2016 CrossRefPubMedPubMedCentral

Morishima T, Restaino RM, Walsh LK, Kanaley JA, Padilla J (2017) Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction. Clin Sci (Lond) 131(11):1045–1053. https://doi.org/10.1042/CS20170031 CrossRef

Morris JN, Heady J, Raffle P, Roberts C, Parks J (1953) Coronary heart-disease and physical activity of work. Lancet 262(6796):1111–1120CrossRef

Moyen NE, Ganio MS, Burchfield JM, Tucker MA, Gonzalez MA, Dougherty EK, Robinson FB, Ridings CB, Veilleux JC (2016) Effect of passive heat stress on arterial stiffness in smokers versus non-smokers. Int J Biometeorol 60(4):499–506. https://doi.org/10.1007/s00484-015-1046-2 CrossRefPubMed

Munir S, Guilcher A, Kamalesh T et al (2008) Peripheral augmentation index defines the relationship between central and peripheral pulse pressure. Hypertens Dallas Tex 1979 51:112–118. https://doi.org/10.1161/HYPERTENSIONAHA.107.096016 CrossRef

Nichols WW, Edwards DG (2001) Arterial elastance and wave reflection augmentation of systolic blood pressure: deleterious effects and implications for therapy. J Cardiovasc Pharmacol Ther 6(1):5–21. https://doi.org/10.1177/107424840100600102 CrossRefPubMed

Nickel KJ, Acree LS, Gardner AW (2011) Effects of a single bout of exercise on arterial compliance in older adults. Angiology 62(1):33–37. https://doi.org/10.1177/0003319710381993 CrossRefPubMedPubMedCentral

Nurnberger J, Michalski R, Turk TR, Opazo Saez A, Witzke O, Kribben A (2011) Can arterial stiffness parameters be measured in the sitting position? Hypertens Res 34(2):202–208. https://doi.org/10.1038/hr.2010.196 CrossRefPubMed

Padilla J, Fadel PJ (2017) Prolonged sitting leg vasculopathy: contributing factors and clinical implications. Am J Physiol Heart Circ Physiol 313(4):H722–H728. https://doi.org/10.1152/ajpheart.00326.2017 CrossRefPubMed

Partsch H, Winiger J, Lun B (2004) Compression stockings reduce occupational leg swelling. Dermatol Surg 30(5):737–743. https://doi.org/10.1111/j.1524-4725.2004.30204.x discussion 743.CrossRefPubMed

Quilici BC, Gildo C Jr, de Godoy JM, Quilici BS, Augusto CR (2009) Comparison of reduction of edema after rest and after muscle exercises in treatment of chronic venous insufficiency. Int Arch Med 2(1):18. https://doi.org/10.1186/1755-7682-2-18 CrossRefPubMedPubMedCentral

Reesink KD, Hermeling E, Hoeberigs MC, Reneman RS, Hoeks AP (2007) Carotid artery pulse wave time characteristics to quantify ventriculoarterial responses to orthostatic challenge. J Appl Physiol 102(6):2128–2134. https://doi.org/10.1152/japplphysiol.01206.2006 CrossRefPubMed

Reiff C, Marlatt K, Dengel DR (2012) Difference in caloric expenditure in sitting versus standing desks. J Phys Act Health 9(7):1009–1011CrossRefPubMed

Restaino RM, Holwerda SW, Credeur DP, Fadel PJ, Padilla J (2015) Impact of prolonged sitting on lower and upper limb micro- and macrovascular dilator function. Exp Physiol 100(7):829–838. https://doi.org/10.1113/EP085238 CrossRefPubMedPubMedCentral

Restaino RM, Walsh LK, Morishima T, Vranish JR, Martinez-Lemus LA, Fadel PJ, Padilla J (2016) Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress. Am J Physiol Heart Circ Physiol 310(5):H648–H653. https://doi.org/10.1152/ajpheart.00943.2015 CrossRefPubMedPubMedCentral

Schwartz B, Kapellusch JM, Schrempf A, Probst K, Haller M, Baca A (2017) Effect of alternating postures on cognitive performance for healthy people performing sedentary work. Ergonomics. https://doi.org/10.1080/00140139.2017.1417642 CrossRefPubMed

Selker R, Love J, Dropmann D (2017) jmv: the ‘jamovi’ analyses. https://CRAN.Rproject.org/package=jmv

Sugawara J, Otsuki T, Tanabe T, Maeda S, Kuno S, Ajisaka R, Matsuda M (2003) The effects of low-intensity single-leg exercise on regional arterial stiffness. Jpn J Physiol 53(3):239–241CrossRefPubMed

Thosar SS, Bielko SL, Wiggins CC, Wallace JP (2014) Differences in brachial and femoral artery responses to prolonged sitting. Cardiovasc Ultrasound 12:50. https://doi.org/10.1186/1476-7120-12-50 CrossRefPubMedPubMedCentral

Thosar SS, Bielko SL, Mather KJ, Johnston JD, Wallace JP (2015) Effect of prolonged sitting and breaks in sitting time on endothelial function. Med Sci Sports Exerc 47(4):843–849CrossRefPubMed

Tomei F, Baccolo TP, Tomao E, Palmi S, Rosati MV (1999) Chronic venous disorders and occupation. Am J Ind Med 36(6):653–665CrossRefPubMed

Townsend RR, Wilkinson IB, Schiffrin EL, Avolio AP, Chirinos JA, Cockcroft JR, Heffernan KS, Lakatta EG, McEniery CM, Mitchell GF, Najjar SS, Nichols WW, Urbina EM, Weber T, American Heart Association Council (2015) Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association. Hypertension 66(3):698–722. https://doi.org/10.1161/HYP.0000000000000033 CrossRefPubMedPubMedCentral

Trinity JD (2017) Something is definitely better than nothing: simple strategies to prevent vascular dysfunction. Clin Sci (Lond) 131(11):1055–1058. https://doi.org/10.1042/CS20170130 CrossRef

Vaitkevicius PV, Fleg JL, Engel JH, O’Connor FC, Wright JG, Lakatta LE, Yin FC, Lakatta EG (1993) Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation 88(4 Pt 1):1456–1462CrossRefPubMed

Vlachopoulos C, O’Rourke M, Nichols WW (2011) McDonald’s blood flow in arteries: theoretical, experimental and clinical principles. CRC Press, Boca Raton

Waters TR, Dick RB (2015) Evidence of health risks associated with prolonged standing at work and intervention effectiveness. Rehabil Nurs 40(3):148–165CrossRefPubMed

Wickham HD (2009) ggplot2: elegant graphics for data analysis. Springer, New YorkCrossRef

Williams MR, Westerman RA, Kingwell BA, Paige J, Blombery PA, Sudhir K, Komesaroff PA (2001) Variations in endothelial function and arterial compliance during the menstrual cycle. J Clin Endocrinol Metab 86(11):5389–5395. https://doi.org/10.1210/jcem.86.11.8013 CrossRefPubMed

Title: Prolonged standing increases lower limb arterial stiffness
Authors: Aaron R. Caldwell
Kaitlin M. Gallagher
Benjamin T. Harris
Megan E. Rosa-Caldwell
Marcus Payne
Bryce Daniels
Matthew S. Ganio
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 10/2018
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-018-3956-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prolonged standing increases lower limb arterial stiffness

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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