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01-05-2018 | Original Article

The acute effect of Quercetin on muscle performance following a single resistance training session

Authors: Federica Patrizio, Massimiliano Ditroilo, Francesco Felici, Guglielmo Duranti, Giuseppe De Vito, Stefania Sabatini, Massimo Sacchetti, Ilenia Bazzucchi

Published in: European Journal of Applied Physiology | Issue 5/2018

Abstract

Purpose

To examine the effect of acute quercetin (Q) ingestion on neuromuscular function, biomarkers of muscle damage, and rate of perceived exertion (RPE) in response to an acute bout of resistance training.

Methods

10 young men (22.1 ± 1.8 years, 24.1 ± 3.1 BMI) participated in a randomized, double-blind, crossover study. Subjects consumed Q (1 g/day) or placebo (PLA) 3 h prior to a resistance training session which consisted of 3 sets of 8 repetitions at 80% of the one repetition maximum (1RM) completed bilaterally for eight different resistance exercises. Electromyographic (EMG) signals were recorded from the knee extensor muscles during maximal isometric (MVIC) and isokinetic voluntary contractions, and during an isometric fatiguing test. Mechanical and EMG signals, biomarkers of cell damage, and RPE score were measured PRE, immediately POST, and 24 h (blood indices only) following the resistance exercise.

Results

After a single dose of Q, the torque–velocity curve of knee extensors was enhanced and after the resistance exercise, subjects showed a lower MVIC reduction (Q: 0.91 ± 6.10%, PLA: 8.66 ± 5.08%) with a greater rate of torque development (+ 10.6%, p < 0.005) and neuromuscular efficiency ratio (+ 28.2%, p < 0.005). Total volume of the resistance exercises was significantly greater in Q (1691.10 ± 376.71 kg rep) compared to PLA (1663.65 ± 378.85 kg rep) (p < 0.05) with a comparable RPE score. No significant differences were found in blood marker between treatments.

Conclusions

The acute ingestion of Q may enhance the neuromuscular performance during and after a resistance training session.

Aagaard P, Simonsen EB, Andersen JL et al (2002) Increased rate of force development and neural drive of human skeletal muscle following resistance training. J Appl Physiol 93:1318–1326. https://doi.org/10.1152/japplphysiol.00283.2002 CrossRefPubMed

Ackerman J, Clifford T, McNaughton LR, Bentley DJ (2014) The effect of an acute antioxidant supplementation compared with placebo on performance and hormonal response during a high volume resistance training session. J Int Soc Sports Nutr 11:10. https://doi.org/10.1186/1550-2783-11-10 CrossRefPubMedPubMedCentral

Alexander SPH (2006) Flavonoids as antagonists at A1 adenosine receptors. Phyther Res 20:1009–1012. https://doi.org/10.1002/ptr.1975 CrossRef

Andersen LL, Aagaard P (2006) Influence of maximal muscle strength and intrinsic muscle contractile properties on contractile rate of force development. Eur J Appl Physiol 96:46–52. https://doi.org/10.1007/s00421-005-0070-z CrossRefPubMed

Bazzucchi I, Riccio ME, Felici F (2008) Tennis players show a lower coactivation of the elbow antagonist muscles during isokinetic exercises. J Electromyogr Kinesiol 18:752–759CrossRefPubMed

Bazzucchi I, Felici F, Sacchetti M (2009) Effect of short-term creatine supplementation on neuromuscular function. Med Sci Sport Exerc. https://doi.org/10.1249/MSS.0b013e3181a2c05c CrossRef

Bazzucchi I, Felici F, Montini M et al (2011) Caffeine improves neuromuscular function during maximal dynamic exercise. Muscle Nerve 43:839–844CrossRefPubMed

Bazzucchi I, Patrizio F, Felici F et al (2016) CHO mouth rinsing improves neuromuscular performance during isokinetic fatiguing exercise. Int J Sports Physiol Perform ahead of p:1–23. https://doi.org/10.1123/ijspp.2016-0583

Bloomer RJ, Goldfarb AH, Wideman L et al (2005) Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res 19:276. https://doi.org/10.1519/14823.1 CrossRefPubMed

Boots AW, Haenen GRMM., Bast A (2008) Health effects of quercetin: From antioxidant to nutraceutical. Eur J Pharmacol 585:325–337. https://doi.org/10.1016/j.ejphar.2008.03.008 CrossRefPubMed

Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14:377–381. https://doi.org/10.1249/00005768-198205000-00012 CrossRefPubMed

Braakhuis AJ, Hopkins WG (2015) Impact of dietary antioxidants on sport performance: a review. Sport Med 45:939–955. https://doi.org/10.1007/s40279-015-0323-x CrossRef

Ceci R, Duranti G, Sgrò P et al (2014) Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity. Eur J Appl Physiol 115:531–539. https://doi.org/10.1007/s00421-014-3040-5 CrossRefPubMed

Ceci R, Duranti G, Leonetti A et al (2017) Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression: evaluation of a new transgenic mouse model. Free Radic Biol Med 103:216–225. https://doi.org/10.1016/j.freeradbiomed.2016.12.040 CrossRefPubMed

Cheuvront SN, Ely BR, Kenefick RW et al (2009) No effect of nutritional adenosine receptor antagonists on exercise performance in the heat. Am J Physiol Regul Integr Comp Physiol 65:R394–R401. https://doi.org/10.1152/ajpregu.90812.2008 CrossRef

Chun OK, Chung SJ, Song WO (2007) Estimated dietary flavonoid intake and major food sources of U.S. adults. J Nutr 137:1244–1252 pii]CrossRefPubMed

Clifford T, Bell O, West DJ et al (2016) The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol 116:353–362. https://doi.org/10.1007/s00421-015-3290-x CrossRefPubMed

Connolly DAJ (2006) Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage * Commentary 1 * Commentary 2. Br J Sports Med 40:679–683. https://doi.org/10.1136/bjsm.2005.025429 CrossRefPubMedPubMedCentral

Davis JM, Murphy EA, Carmichael MD (2009) Effects of the dietary flavonoid quercetin upon performance and health. Curr Sports Med Rep 8:206–213. https://doi.org/10.1249/JSR.0b013e3181ae8959 CrossRefPubMed

Davison G, Callister R, Williamson G et al (2012) The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise. Eur J Nutr 51:69–79. https://doi.org/10.1007/s00394-011-0193-4 CrossRefPubMed

De Vito G, McHugh D, Macaluso A, Riches PE (2003) Is the coactivation of biceps femoris during isometric knee extension affected by adiposity in healthy young humans? J Electromyogr Kinesiol 13:425–431. https://doi.org/10.1016/S1050-6411(03)00061-0 CrossRefPubMed

Farina D (2004) The extraction of neural strategies from the surface EMG. J Appl Physiol 96:1486–1495. https://doi.org/10.1152/japplphysiol.01070.2003 CrossRefPubMed

García-Alonso J, Ros G, Vidal-Guevara ML, Periago MJ (2006) Acute intake of phenolic-rich juice improves antioxidant status in healthy subjects. Nutr Res 26:330–339. https://doi.org/10.1016/j.nutres.2006.06.004 CrossRef

Goldfarb AH, Bloomer RJ, Mckenzie MJ (2005) Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise. Med Sci Sports Exerc 37:234–239. https://doi.org/10.1249/01.MSS.0000152887.87785.BE CrossRefPubMed

Goldfarb AH, Garten RS, Cho C et al (2011) Effects of a fruit/berry/vegetable supplement on muscle function and oxidative stress. Med Sci Sports Exerc 43:501–508. https://doi.org/10.1249/MSS.0b013e3181f1ef48 CrossRefPubMed

Harwood M, Danielewska-Nikiel B, Borzelleca JF et al (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45:2179–2205. https://doi.org/10.1016/j.fct.2007.05.015 CrossRefPubMed

Hermens HJ, Freriks B, Disselhorst-Klug C, Rau G (2000) Development of recommendations for SEMG sensors and sensor placement procedures. J Electromyogr Kinesiol 10:361–374. https://doi.org/10.1016/S1050-6411(00)00027-4 CrossRefPubMed

Hollman PCH, Gaag MVD, Mengelers MJB et al (1996) Absorption and disposition kinetics of the dietary antioxidant quercetin in man. Free Radic Biol Med 21:703–707. https://doi.org/10.1016/0891-5849(96)00129-3 CrossRefPubMed

Kale A, Gawande S, Kotwal S et al (2010) Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extract. Phyther Res. https://doi.org/10.1002/ptr.2899 CrossRef

Kaushik D, O’Fallon K, Clarkson PM et al (2012) Comparison of quercetin pharmacokinetics following oral supplementation in humans. J Food Sci doi. https://doi.org/10.1111/j.1750-3841.2012.02934.x CrossRef

Kim DH, Ohnishi ST, Ikemoto N (1983) Kinetic studies of calcium release from sarcoplasmic reticulum in vitro. J Biol Chem 258:9662–9668PubMed

Konrad M, Nieman DC, Henson DA et al (2011) The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. Int J Sport Nutr Exerc Metab 21:338–346. https://doi.org/10.1249/01.MSS.0000402819.42267.6d CrossRefPubMed

Larson A, Witman MAH, Guo Y et al (2012) Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: Nitric oxide. Nutr Res 32:557–564. https://doi.org/10.1016/j.nutres.2012.06.018 CrossRefPubMed

Lee EH, Meissner G, Kim DH (2002) Effects of quercetin on single Ca²⁺ release channel behavior of skeletal muscle. Biophys J 82:1266–1277. https://doi.org/10.1016/S0006-3495(02)75483-0 CrossRefPubMedPubMedCentral

MacRae HSH, Mefferd KM (2006) Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance. Int J Sport Nutr Exerc Metab 16:405–419CrossRefPubMed

O’Fallon KS, Kaushik D, Michniak-Kohn B et al (2012) Effects of quercetin supplementation on markers of muscle damage and inflammation after eccentric exercise. Int J Sport Nutr Exerc Metab 22:430–437CrossRefPubMed

Paulsen G, Hamarsland H, Cumming KT et al (2014) Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training. J Physiol 592:5391–5408. https://doi.org/10.1113/jphysiol.2014.279950 CrossRefPubMedPubMedCentral

Phillips T, Childs AC, Dreon DM et al (2003) A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Med Sci Sports Exerc 35:2032–2037. https://doi.org/10.1249/01.MSS.0000099112.32342.10 CrossRefPubMed

Powers SK, Nelson WB, Hudson MB (2011) Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 51:942–950. https://doi.org/10.1016/j.freeradbiomed.2010.12.009 CrossRefPubMed

Rainoldi A, Galardi G, Maderna L et al (1999) Repeatability of surface EMG variables during voluntary isometric contractions of the biceps brachii muscle. J Electromyogr Kinesiol 9:105–119. https://doi.org/10.1016/S1050-6411(98)00042-X CrossRefPubMed

Rainoldi A, Gazzoni M, Casale R (2008) Surface EMG signal alterations in carpal tunnel syndrome: a pilot study. Eur J Appl Physiol 103:233–242. https://doi.org/10.1007/s00421-008-0694-x CrossRefPubMed

Remaud A (2005) A methodologic approach for the neuromuscular system

Schoenfeld BJ, Ratamess NA, Peterson MD et al (2014) Effects of different volume-equated resistance training loading strategies on muscular adaptations in well-trained men. J Strength Cond Res 28:2909–2918. https://doi.org/10.1519/JSC.0000000000000480 CrossRefPubMed

Sureda A, Tejada S, Bibiloni M et al (2014) Polyphenols: well beyond the antioxidant capacity: polyphenol supplementation and exercise-induced oxidative stress and inflammation. Curr Pharm Biotechnol 15:373–379. https://doi.org/10.2174/1389201015666140813123843 CrossRefPubMed

Urso ML, Clarkson PM (2003) Oxidative stress, exercise, and antioxidant supplementation. Toxicology 189:41–54. https://doi.org/10.1016/S0300-483X(03)00151-3 CrossRefPubMed

USDA NASS (2009) 2007 Census of Agriculture. 1:p 739

Wu R, Delahunt E, Ditroilo M et al (2016) Effects of age and sex on neuromuscular-mechanical determinants of muscle strength. Age (Omaha). https://doi.org/10.1007/s11357-016-9921-2 CrossRefPubMedPubMedCentral

Title: The acute effect of Quercetin on muscle performance following a single resistance training session
Authors: Federica Patrizio
Massimiliano Ditroilo
Francesco Felici
Guglielmo Duranti
Giuseppe De Vito
Stefania Sabatini
Massimo Sacchetti
Ilenia Bazzucchi
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 5/2018
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-018-3834-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The acute effect of Quercetin on muscle performance following a single resistance training session

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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