Sodium bicarbonate supplementation improves severe-intensity intermittent exercise under moderate acute hypoxic conditions

Acute moderate hypoxic exposure can substantially impair exercise performance, which occurs with a concurrent exacerbated rise in hydrogen cation (H⁺) production. The purpose of this study was therefore, to alleviate this acidic stress through sodium bicarbonate (NaHCO₃) supplementation and determine the corresponding effects on severe-intensity intermittent exercise performance. Eleven recreationally active individuals participated in this randomised, double-blind, crossover study performed under acute normobaric hypoxic conditions (FiO₂% = 14.5%). Pre-experimental trials involved the determination of time to attain peak bicarbonate anion concentrations ([HCO₃⁻]) following NaHCO₃ ingestion. The intermittent exercise tests involved repeated 60-s work in their severe-intensity domain and 30-s recovery at 20 W to exhaustion. Participants ingested either 0.3 g kg bm⁻¹ of NaHCO₃ or a matched placebo of 0.21 g kg bm⁻¹ of sodium chloride prior to exercise. Exercise tolerance (+ 110.9 ± 100.6 s; 95% CI 43.3–178 s; g = 1.0) and work performed in the severe-intensity domain (+ 5.8 ± 6.6 kJ; 95% CI 1.3–9.9 kJ; g = 0.8) were enhanced with NaHCO₃ supplementation. Furthermore, a larger post-exercise blood lactate concentration was reported in the experimental group (+ 4 ± 2.4 mmol l⁻¹; 95% CI 2.2–5.9; g = 1.8), while blood [HCO₃⁻] and pH remained elevated in the NaHCO₃ condition throughout experimentation. In conclusion, this study reported a positive effect of NaHCO₃ under acute moderate hypoxic conditions during intermittent exercise and therefore, may offer an ergogenic strategy to mitigate hypoxic induced declines in exercise performance.