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01-11-2017 | Original Article

Cardiorespiratory fitness and inflammatory profile on cardiometabolic risk in adolescents from the LabMed Physical Activity Study

Authors: César A. Agostinis-Sobrinho, Jonatan R. Ruiz, Carla Moreira, Sandra Abreu, Lopes Luís, José Oliveira-Santos, Jorge Mota, Rute Santos

Published in: European Journal of Applied Physiology | Issue 11/2017

Abstract

Purpose

We investigated the combined effect of cardiorespiratory fitness and the clustered score of inflammatory biomarkers (InflaScore) on the cardiometabolic risk score in adolescents.

Methods

This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12–18 years. The shuttle run test was used to assess cardiorespiratory fitness. Continuous scores of clustered inflammatory biomarkers (high sensitivity C-reactive protein, complement factors C3 and C4, fibrinogen and leptin); cardiometabolic risk score (systolic blood pressure, triglycerides, ratio total cholesterol/HDL, HOMA-IR and waist circumference) were computed.

Results

Adolescents with a higher inflammatory profile had the highest cardiometabolic risk score; adolescents with high InflaScore and low fitness had the highest odds of having a high cardiometabolic risk (OR 16.5; 95% CI 7.8–34.5), followed by adolescents with a higher InflaScore but fit (OR 7.5; 95% CI 3.7–8.4), and then by adolescents with a low InflaScore and unfit (OR 3.7; 95% CI 1.6–8.4) when compared to those with low InflaScore and fit, after adjustments for age, sex, pubertal stage, adherence to a Mediterranean dietary pattern and socioeconomic status.

Conclusions

The findings of our study suggest that the combination of high inflammatory state and low cardiorespiratory fitness is synergistically associated with a significantly higher cardiometabolic risk score and thus supports the relevance of early targeted interventions to promote physical activity and preservation as part of primordial prevention.

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Title: Cardiorespiratory fitness and inflammatory profile on cardiometabolic risk in adolescents from the LabMed Physical Activity Study
Authors: César A. Agostinis-Sobrinho
Jonatan R. Ruiz
Carla Moreira
Sandra Abreu
Lopes Luís
José Oliveira-Santos
Jorge Mota
Rute Santos
Publication date: 01-11-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 11/2017
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-017-3714-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Cardiorespiratory fitness and inflammatory profile on cardiometabolic risk in adolescents from the LabMed Physical Activity Study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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