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European Journal of Applied Physiology

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Open Access 01-05-2017 | Original Article

Intestinal fatty acid-binding protein and gut permeability responses to exercise

Authors: Daniel S. March, Tania Marchbank, Raymond J. Playford, Arwel W. Jones, Rhys Thatcher, Glen Davison

Published in: European Journal of Applied Physiology | Issue 5/2017

Abstract

Purpose

Intestinal cell damage due to physiological stressors (e.g. heat, oxidative, hypoperfusion/ischaemic) may contribute to increased intestinal permeability. The aim of this study was to assess changes in plasma intestinal fatty acid-binding protein (I-FABP) in response to exercise (with bovine colostrum supplementation, Col, positive control) and compare this to intestinal barrier integrity/permeability (5 h urinary lactulose/rhamnose ratio, L/R).

Methods

In a double-blind, placebo-controlled, crossover design, 18 males completed two experimental arms (14 days of 20 g/day supplementation with Col or placebo, Plac). For each arm participants performed two baseline (resting) intestinal permeability assessments (L/R) pre-supplementation and one post-exercise following supplementation. Blood samples were collected pre- and post-exercise to determine I-FABP concentration.

Results

Two-way repeated measures ANOVA revealed an arm × time interaction for L/R and I-FABP (P < 0.001). Post hoc analyses showed urinary L/R increased post-exercise in Plac (273% of pre, P < 0.001) and Col (148% of pre, P < 0.001) with post-exercise values significantly lower with Col (P < 0.001). Plasma I-FABP increased post-exercise in Plac (191% of pre-exercise, P = 0.002) but not in the Col arm (107%, P = 0.862) with post-exercise values significantly lower with Col (P = 0.013). Correlations between the increase in I-FABP and L/R were evident for visit one (P = 0.044) but not visit two (P = 0.200) although overall plots/patterns do appear similar for each.

Conclusion

These findings suggest that exercise-induced intestinal cellular damage/injury is partly implicated in changes in permeability but other factors must also contribute.

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Title: Intestinal fatty acid-binding protein and gut permeability responses to exercise
Authors: Daniel S. March
Tania Marchbank
Raymond J. Playford
Arwel W. Jones
Rhys Thatcher
Glen Davison
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 5/2017
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-017-3582-4

ACC 2024 Congress

Springer Medicine

Intestinal fatty acid-binding protein and gut permeability responses to exercise

Abstract

Purpose

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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