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01-07-2016 | Original Article

Impact of aortic root size on left ventricular afterload and stroke volume

Authors: Anders Sahlén, Nadira Hamid, Mohammed Rizwan Amanullah, Jiang Ming Fam, Khung Keong Yeo, Yee How Lau, Carolyn S. P. Lam, Zee Pin Ding

Published in: European Journal of Applied Physiology | Issue 7/2016

Abstract

Purpose

The left ventricle (LV) ejects blood into the proximal aorta. Age and hypertension are associated with stiffening and dilation of the aortic root, typically viewed as indicative of adverse remodeling. Based on analytical considerations, we hypothesized that a larger aortic root should be associated with lower global afterload (effective arterial elastance, E_A) and larger stroke volume (SV). Moreover, as antihypertensive drugs differ in their effect on central blood pressure, we examined the role of antihypertensive drugs for the relation between aortic root size and afterload.

Methods

We studied a large group of patients (n = 1250; 61 ± 12 years; 78 % males; 64 % hypertensives) from a single-center registry with known or suspected coronary artery disease. Aortic root size was measured by echocardiography as the diameter of the tubular portion of the ascending aorta. LV outflow tract Doppler was used to record SV.

Results

In the population as a whole, after adjusting for key covariates in separate regression models, aortic root size was an independent determinant of both SV and E_A. This association was found to be heterogeneous and stronger in patients taking a calcium channel blocker (CCB; 10.6 % of entire population; aortic root size accounted for 8 % of the explained variance of E_A).

Conclusion

Larger aortic root size is an independent determinant of E_A and SV. This association was heterogeneous and stronger in patients on CCB therapy.

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Title: Impact of aortic root size on left ventricular afterload and stroke volume
Authors: Anders Sahlén
Nadira Hamid
Mohammed Rizwan Amanullah
Jiang Ming Fam
Khung Keong Yeo
Yee How Lau
Carolyn S. P. Lam
Zee Pin Ding
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 7/2016
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-016-3392-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Impact of aortic root size on left ventricular afterload and stroke volume

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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