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European Journal of Applied Physiology

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01-01-2015 | Original Article

Time-course of vascular adaptations during 8 weeks of exercise training in subjects with type 2 diabetes and middle-aged controls

Authors: Tim H. A. Schreuder, Daniel J. Green, Jean Nyakayiru, Maria T. E. Hopman, Dick H. J. Thijssen

Published in: European Journal of Applied Physiology | Issue 1/2015

Abstract

Purpose

Exercise training in healthy volunteers rapidly improves vascular function, preceding structural remodelling. No study examined the time-course of such adaptations in subjects with a priori endothelial dysfunction.

Methods

We examined brachial artery endothelial and smooth muscle function using flow-mediated dilation (FMD) and glyceryl trinitrate (GTN) administration in 13 type 2 diabetes patients (59 ± 6 years) and 10 healthy subjects (58 ± 7 years) before, during (2-weekly) and after an 8-week training programme. Arterial structure was assessed via peak blood flow and artery diameter.

Results

Training increased peak oxygen uptake (P = 0.03), comparable between groups (P = 0.276). We observed a similar impact of training on brachial artery vasomotor function across the training period in diabetes patients and controls (FMD/GTN-ratio), with a higher FMD/GTN-ratio at 2, 6 and 8 weeks (P = 0.036). Artery diameter, peak blood flow or peak diameter had not changed after training.

Conclusion

Training leads to rapid improvement in brachial artery vascular function in diabetes patients and controls. In contrast to previous observations in healthy young subjects, the increase in function was preserved after 8 weeks of training in middle-aged diabetes patients and controls, suggesting a different time-course in vascular adaptations in subjects with endothelial dysfunction.

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Title: Time-course of vascular adaptations during 8 weeks of exercise training in subjects with type 2 diabetes and middle-aged controls
Authors: Tim H. A. Schreuder
Daniel J. Green
Jean Nyakayiru
Maria T. E. Hopman
Dick H. J. Thijssen
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 1/2015
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-014-3006-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Time-course of vascular adaptations during 8 weeks of exercise training in subjects with type 2 diabetes and middle-aged controls

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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