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European Journal of Applied Physiology

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01-05-2014 | Original Article

Muscle damage responses and adaptations to eccentric-overload resistance exercise in men and women

Authors: Rodrigo Fernandez-Gonzalo, Tommy R. Lundberg, Lucia Alvarez-Alvarez, José A. de Paz

Published in: European Journal of Applied Physiology | Issue 5/2014

Abstract

Purpose

This study assessed markers of muscle damage and training adaptations to eccentric-overload flywheel resistance exercise (RE) in men and women.

Methods

Dynamic strength (1 RM), jump performance, maximal power at different percentages of 1 RM, and muscle mass in three different portions of the thigh were assessed in 16 men and 16 women before and after 6 weeks (15 sessions) of flywheel supine squat RE training. Plasma creatine kinase (CK) and lactate dehydrogenase (LDH) concentrations were measured before, 24, 48 and 72 h after the first and the last training session.

Results

After training, increases in 1 RM were somewhat greater (interaction P < 0.001) in men (25 %) than in women (20 %). Squat and drop jump height and power performance at 50, 60, 70 and 80 % of 1 RM increased after training in both sexes (P < 0.05). Power improvement at 80 % of 1 RM was greater (interaction P < 0.02) in men than women. Muscle mass increased ~5 % in both groups (P < 0.05). CK increased in men after the first training session (P < 0.001), whereas the response in women was unaltered. In both sexes, LDH concentration was greater after the first training session compared with basal values (P < 0.05). After the last session, CK and LDH remained at baseline in both groups.

Conclusions

These results suggest that although improvements in maximal strength and power at high loads may be slightly greater for men, eccentric-overload RE training induces comparable and favorable gains in strength, power, and muscle mass in both men and women. Equally important, it appears muscle damage does not interfere with the adaptations triggered by this training paradigm.

Abe T, DeHoyos DV, Pollock ML, Garzarella L (2000) Time course for strength and muscle thickness changes following upper and lower body resistance training in men and women. Eur J Appl Physiol 81(3):174–180. doi:10.1007/s004210050027 PubMedCrossRef

Alkner BA, Tesch PA (2004a) Efficacy of a gravity-independent resistance exercise device as a countermeasure to muscle atrophy during 29-day bed rest. Acta Physiol Scand 181(3):345–357. doi:10.1111/j.1365-201X.2004.01293.x PubMedCrossRef

Alkner BA, Tesch PA (2004b) Knee extensor and plantar flexor muscle size and function following 90 days of bed rest with or without resistance exercise. Eur J Appl Physiol 93(3):294–305. doi:10.1007/s00421-004-1172-8 PubMedCrossRef

Allen DG (2001) Eccentric muscle damage: mechanisms of early reduction of force. Acta Physiol Scand 171(3):311–319. doi:10.1046/j.1365-201x.2001.00833.x PubMedCrossRef

Andreoli A, Scalzo G, Masala S, Tarantino U, Guglielmi G (2009) Body composition assessment by dual-energy X-ray absorptiometry (DXA). Radiol Med 114(2):286–300. doi:10.1007/s11547-009-0369-7 PubMedCrossRef

Askling C, Karlsson J, Thorstensson A (2003) Hamstring injury occurrence in elite soccer players after preseason strength training with eccentric overload. Scand J Med Sci Sports 13(4):244–250PubMedCrossRef

Barroso R, Roschel H, Ugrinowitsch C, Araujo R, Nosaka K, Tricoli V (2010) Effect of eccentric contraction velocity on muscle damage in repeated bouts of elbow flexor exercise. Appl Physiol Nutr Metab 35(4):534–540. doi:10.1139/H10-042 PubMedCrossRef

Berg HE, Tesch A (1994) A gravity-independent ergometer to be used for resistance training in space. Aviat Space Environ Med 65(8):752–756PubMed

Billaut F, Smith K (2009) Sex alters impact of repeated bouts of sprint exercise on neuromuscular activity in trained athletes. Appl Physiol Nutr Metab 34(4):689–699. doi:10.1139/H09-058 PubMedCrossRef

Cannon JG, Meydani SN, Fielding RA, Fiatarone MA, Meydani M, Farhangmehr M, Orencole SF, Blumberg JB, Evans WJ (1991) Acute phase response in exercise. II. Associations between vitamin E, cytokines, and muscle proteolysis. Am J Physiol 260(6 Pt 2):1235–1240

Chen TC, Chen HL, Lin MJ, Wu CJ, Nosaka K (2009) Muscle damage responses of the elbow flexors to four maximal eccentric exercise bouts performed every 4 weeks. Eur J Appl Physiol 106(2):267–275. doi:10.1007/s00421-009-1016-7 PubMedCrossRef

Colliander EB, Tesch PA (1990) Effects of eccentric and concentric muscle actions in resistance training. Acta Physiol Scand 140(1):31–39PubMedCrossRef

Colliander EB, Tesch PA (1991) Responses to eccentric and concentric resistance training in females and males. Acta Physiol Scand 141(2):149–156PubMedCrossRef

Colliander EB, Tesch PA (1992) Effects of detraining following short term resistance training on eccentric and concentric muscle strength. Acta Physiol Scand 144(1):23–29PubMedCrossRef

Delmonico MJ, Kostek MC, Doldo NA, Hand BD, Bailey JA, Rabon-Stith KM, Conway JM, Carignan CR, Lang J, Hurley BF (2005) Effects of moderate-velocity strength training on peak muscle power and movement velocity: do women respond differently than men? J Appl Physiol 99(5):1712–1718. doi:10.1152/japplphysiol.01204.2004 PubMedCrossRef

Dudley GA, Tesch PA, Harris RT, Golden CL, Buchanan P (1991a) Influence of eccentric actions on the metabolic cost of resistance exercise. Aviat Space Environ Med 62(7):678–682PubMed

Dudley GA, Tesch PA, Miller BJ, Buchanan P (1991b) Importance of eccentric actions in performance adaptations to resistance training. Aviat Space Environ Med 62(6):543–550PubMed

Esbjornsson M, Rundqvist HC, Mascher H, Osterlund T, Rooyackers O, Blomstrand E, Jansson E (2012) Sprint exercise enhances skeletal muscle p70S6 k phosphorylation and more so in women than in men. Acta Physiol (Oxf) 205(3):411–422. doi:10.1111/j.1748-1716.2012.02404.x CrossRef

Fernandez-Gonzalo R, De Paz JA, Rodriguez-Miguelez P, Cuevas MJ, Gonzalez-Gallego J (2012) Effects of eccentric exercise on toll-like receptor 4 signaling pathway in peripheral blood mononuclear cells. J Appl Physiol 112(12):2011–2018. doi:10.1152/japplphysiol.01499.2011 PubMedCrossRef

Garcia-Lopez D, Cuevas MJ, Almar M, Lima E, De Paz JA, Gonzalez-Gallego J (2007) Effects of eccentric exercise on NF-kappaB activation in blood mononuclear cells. Med Sci Sports Exerc 39(4):653–664. doi:10.1249/mss.0b013e31802f04f6 PubMedCrossRef

Golden CL, Dudley GA (1992) Strength after bouts of eccentric or concentric actions. Med Sci Sports Exerc 24(8):926–933PubMedCrossRef

Hansen RD, Williamson DA, Finnegan TP, Lloyd BD, Grady JN, Diamond TH, Smith EUR, Stavrinos TM, Thompson MW, Gwinn TH (2007) Estimation of thigh muscle cross-sectional area by dual-energy X-ray absorptiometry in frail elderly patients. Am J Clin Nutr 86(4):952PubMed

Hather BM, Tesch PA, Buchanan P, Dudley GA (1991) Influence of eccentric actions on skeletal muscle adaptations to resistance training. Acta Physiol Scand 143(2):177–185PubMedCrossRef

Hubal MJ, Gordish-Dressman H, Thompson PD, Price TB, Hoffman EP, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Clarkson PM (2005) Variability in muscle size and strength gain after unilateral resistance training. Med Sci Sports Exerc 37(6):964–972PubMed

Kraemer WJ, Staron RS, Hagerman FC, Hikida RS, Fry AC, Gordon SE, Nindl BC, Gothshalk LA, Volek JS, Marx JO, Newton RU, Hakkinen K (1998) The effects of short-term resistance training on endocrine function in men and women. Eur J Appl Physiol Occup Physiol 78(1):69–76PubMedCrossRef

Krentz JR, Farthing JP (2010) Neural and morphological changes in response to a 20-day intense eccentric training protocol. Eur J Appl Physiol 110(2):333–340. doi:10.1007/s00421-010-1513-8 PubMedCrossRef

Lundberg TR, Fernandez-Gonzalo R, Gustafsson T, Tesch PA (2013) Aerobic exercise does not compromise muscle hypertrophy response to short-term resistance training. J Appl Physiol 114(1):81–89. doi:10.1152/japplphysiol.01013.2012 PubMedCrossRef

Mastaloudis A, Traber MG, Carstensen K, Widrick JJ (2006) Antioxidants did not prevent muscle damage in response to an ultramarathon run. Med Sci Sports Exerc 38(1):72–80. doi:00005768-200601000-00012 PubMedCrossRef

Melnyk JA, Rogers MA, Hurley BF (2009) Effects of strength training and detraining on regional muscle in young and older men and women. Eur J Appl Physiol 105(6):929–938. doi:10.1007/s00421-008-0979-0 PubMedCrossRef

Milias GA, Nomikos T, Fragopoulou E, Athanasopoulos S, Antonopoulou S (2005) Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers. Eur J Appl Physiol 95(5–6):504–513. doi:10.1007/s00421-005-0031-6 PubMedCrossRef

Miller AE, MacDougall JD, Tarnopolsky MA, Sale DG (1993) Gender differences in strength and muscle fiber characteristics. Eur J Appl Physiol Occup Physiol 66(3):254–262PubMedCrossRef

Neme Ide B, Alessandro Soares Nunes L, Brenzikofer R, Macedo DV (2013) Time course of muscle damage and inflammatory responses to resistance training with eccentric overload in trained individuals. Mediat Inflamm 2013:204942. doi:10.1155/2013/204942 CrossRef

Norrbrand L, Fluckey JD, Pozzo M, Tesch PA (2008) Resistance training using eccentric overload induces early adaptations in skeletal muscle size. Eur J Appl Physiol 102(3):271–281. doi:10.1007/s00421-007-0583-8 PubMedCrossRef

Norrbrand L, Pozzo M, Tesch PA (2010) Flywheel resistance training calls for greater eccentric muscle activation than weight training. Eur J Appl Physiol 110(5):997–1005. doi:10.1007/s00421-010-1575-7 PubMedCrossRef

Norrbrand L, Tous-Fajardo J, Vargas R, Tesch PA (2011) Quadriceps muscle use in the flywheel and barbell squat. Aviat Space Environ Med 82(1):13–19PubMedCrossRef

Nosaka K, Newton M (2002) Concentric or eccentric training effect on eccentric exercise-induced muscle damage. Med Sci Sports Exerc 34(1):63–69PubMedCrossRef

O’Hagan FT, Sale DG, MacDougall JD, Garner SH (1995) Response to resistance training in young women and men. Int J Sports Med 16(5):314–321. doi:10.1055/s-2007-973012 PubMedCrossRef

Petrella JK, Kim JS, Tuggle SC, Bamman MM (2007) Contributions of force and velocity to improved power with progressive resistance training in young and older adults. Eur J Appl Physiol 99(4):343–351. doi:10.1007/s00421-006-0353-z PubMedCrossRef

Ploutz-Snyder LL, Giamis EL, Formikell M, Rosenbaum AE (2001) Resistance training reduces susceptibility to eccentric exercise-induced muscle dysfunction in older women. J Gerontol A Biol Sci Med Sci 56(9):384–390CrossRef

Rittweger J, Felsenberg D, Maganaris C, Ferretti JL (2007) Vertical jump performance after 90 days bed rest with and without flywheel resistive exercise, including a 180 days follow-up. Eur J Appl Physiol 100(4):427–436. doi:10.1007/s00421-007-0443-6 PubMedCrossRef

Romero-Rodriguez D, Gual G, Tesch PA (2011) Efficacy of an inertial resistance training paradigm in the treatment of patellar tendinopathy in athletes: a case-series study. Phys Ther Sport 12(1):43–48. doi:10.1016/j.ptsp.2010.10.003 PubMedCrossRef

Schroeder ET, Hawkins SA, Jaque SV (2004) Musculoskeletal adaptations to 16 weeks of eccentric progressive resistance training in young women. J Strength Cond Res 18(2):227–235. doi:10.1519/r-13443.1 PubMedCrossRef

Shephard RJ (2000) Exercise and training in women, part I: influence of gender on exercise and training responses. Can J Appl Physiol 25(1):19–34PubMedCrossRef

Staron RS, Karapondo DL, Kraemer WJ, Fry AC, Gordon SE, Falkel JE, Hagerman FC, Hikida RS (1994) Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 76(3):1247–1255PubMed

Stupka N, Lowther S, Chorneyko K, Bourgeois JM, Hogben C, Tarnopolsky MA (2000) Gender differences in muscle inflammation after eccentric exercise. J Appl Physiol 89(6):2325–2332PubMed

Stupka N, Tarnopolsky MA, Yardley NJ, Phillips SM (2001) Cellular adaptation to repeated eccentric exercise-induced muscle damage. J Appl Physiol 91(4):1669–1678PubMed

Tesch PA, Ekberg A, Lindquist DM, Trieschmann JT (2004) Muscle hypertrophy following 5-week resistance training using a non-gravity-dependent exercise system. Acta Physiol Scand 180(1):89–98PubMedCrossRef

Thompson HS, Scordilis SP (1994) Ubiquitin changes in human biceps muscle following exercise-induced damage. Biochem Biophys Res Commun 204(3):1193–1198. doi:10.1006/bbrc.1994.2589 PubMedCrossRef

Tiidus PM (2000) Estrogen and gender effects on muscle damage, inflammation, and oxidative stress. Can J Appl Physiol 25(4):274–287PubMedCrossRef

Trappe TA, Burd NA, Louis ES, Lee GA, Trappe SW (2007) Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women. Acta Physiol (Oxf) 191(2):147–159. doi:10.1111/j.1748-1716.2007.01728.x CrossRef

Velders M, Diel P (2013) How sex hormones promote skeletal muscle regeneration. Sports Med 43(11):1089–1100. doi:10.1007/s40279-013-0081-6 PubMedCrossRef

Title: Muscle damage responses and adaptations to eccentric-overload resistance exercise in men and women
Authors: Rodrigo Fernandez-Gonzalo
Tommy R. Lundberg
Lucia Alvarez-Alvarez
José A. de Paz
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 5/2014
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-014-2836-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Muscle damage responses and adaptations to eccentric-overload resistance exercise in men and women

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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