Skip to main content
Top
Published in: European Journal of Applied Physiology 7/2012

01-07-2012 | Original Article

Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training

Authors: Richard S. Metcalfe, John A. Babraj, Samantha G. Fawkner, Niels B. J. Vollaard

Published in: European Journal of Applied Physiology | Issue 7/2012

Login to get access

Abstract

High-intensity interval training (HIT) has been proposed as a time-efficient alternative to traditional cardiorespiratory exercise training, but is very fatiguing. In this study, we investigated the effects of a reduced-exertion HIT (REHIT) exercise intervention on insulin sensitivity and aerobic capacity. Twenty-nine healthy but sedentary young men and women were randomly assigned to the REHIT intervention (men, n = 7; women, n = 8) or a control group (men, n = 6; women, n = 8). Subjects assigned to the control groups maintained their normal sedentary lifestyle, whilst subjects in the training groups completed three exercise sessions per week for 6 weeks. The 10-min exercise sessions consisted of low-intensity cycling (60 W) and one (first session) or two (all other sessions) brief ‘all-out’ sprints (10 s in week 1, 15 s in weeks 2–3 and 20 s in the final 3 weeks). Aerobic capacity (\( \dot{V}{\text{O}}{}_{ 2}{\text{peak}} \)) and the glucose and insulin response to a 75-g glucose load (OGTT) were determined before and 3 days after the exercise program. Despite relatively low ratings of perceived exertion (RPE 13 ± 1), insulin sensitivity significantly increased by 28% in the male training group following the REHIT intervention (P < 0.05). \( \dot{V}{\text{O}}{}_{ 2}{\text{peak}} \) increased in the male training (+15%) and female training (+12%) groups (P < 0.01). In conclusion we show that a novel, feasible exercise intervention can improve metabolic health and aerobic capacity. REHIT may offer a genuinely time-efficient alternative to HIT and conventional cardiorespiratory exercise training for improving risk factors of T2D.
Literature
go back to reference Allender S, Peto V, Scarborough P, Kaur A, Rayner M (2008) Coronary heart disease statistics. British Heart Foundation Health Promotion Research Group, Oxford Allender S, Peto V, Scarborough P, Kaur A, Rayner M (2008) Coronary heart disease statistics. British Heart Foundation Health Promotion Research Group, Oxford
go back to reference Babraj JA, Vollaard NB, Keast C, Guppy FM, Cottrell G, Timmons JA (2009) Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC Endocr Disord 9:3. doi:10.1186/1472-6823-9-3 PubMedCrossRef Babraj JA, Vollaard NB, Keast C, Guppy FM, Cottrell G, Timmons JA (2009) Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC Endocr Disord 9:3. doi:10.​1186/​1472-6823-9-3 PubMedCrossRef
go back to reference Baker JS, Bailey DM, Davies B (2001) The relationship between total-body mass, fat-free mass and cycle ergometry power components during 20 seconds of maximal exercise. J Sci Med Sport 4(1):1–9PubMedCrossRef Baker JS, Bailey DM, Davies B (2001) The relationship between total-body mass, fat-free mass and cycle ergometry power components during 20 seconds of maximal exercise. J Sci Med Sport 4(1):1–9PubMedCrossRef
go back to reference Booth FW, Chakravarthy MV, Spangenburg EE (2002) Exercise and gene expression: physiological regulation of the human genome through physical activity. J Physiol 543(Pt 2):399–411 pii: PHY_019265PubMedCrossRef Booth FW, Chakravarthy MV, Spangenburg EE (2002) Exercise and gene expression: physiological regulation of the human genome through physical activity. J Physiol 543(Pt 2):399–411 pii: PHY_019265PubMedCrossRef
go back to reference Borg G (1970) Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med 2(2–3):92–98PubMed Borg G (1970) Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med 2(2–3):92–98PubMed
go back to reference Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14(5):377–381PubMed Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14(5):377–381PubMed
go back to reference Bouchard C, Rankinen T (2001) Individual differences in response to regular physical activity. Med Sci Sports Exerc 33(6 Suppl):S446–S451 (discussion S452–443)PubMed Bouchard C, Rankinen T (2001) Individual differences in response to regular physical activity. Med Sci Sports Exerc 33(6 Suppl):S446–S451 (discussion S452–443)PubMed
go back to reference Boule NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C (2005) Effects of exercise training on glucose homeostasis: the HERITAGE family study. Diabetes Care 28(1):108–114 pii:28/1/108PubMedCrossRef Boule NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C (2005) Effects of exercise training on glucose homeostasis: the HERITAGE family study. Diabetes Care 28(1):108–114 pii:28/1/108PubMedCrossRef
go back to reference Burgomaster KA, Cermak NM, Phillips SM, Benton CR, Bonen A, Gibala MJ (2007) Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining. Am J Physiol Regul Integr Comp Physiol 292(5):R1970–R1976. doi:10.1152/ajpregu.00503.2006 PubMedCrossRef Burgomaster KA, Cermak NM, Phillips SM, Benton CR, Bonen A, Gibala MJ (2007) Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining. Am J Physiol Regul Integr Comp Physiol 292(5):R1970–R1976. doi:10.​1152/​ajpregu.​00503.​2006 PubMedCrossRef
go back to reference Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, Macdonald MJ, McGee SL, Gibala MJ (2008) Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol 586(1):151–160. doi:10.1113/jphysiol.2007.142109 PubMedCrossRef Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, Macdonald MJ, McGee SL, Gibala MJ (2008) Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol 586(1):151–160. doi:10.​1113/​jphysiol.​2007.​142109 PubMedCrossRef
go back to reference Cederholm J, Wibell L (1990) Insulin release and peripheral sensitivity at the oral glucose-tolerance test. Diabetes Res Clin Pract 10(2):167–175PubMedCrossRef Cederholm J, Wibell L (1990) Insulin release and peripheral sensitivity at the oral glucose-tolerance test. Diabetes Res Clin Pract 10(2):167–175PubMedCrossRef
go back to reference Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. doi:10.1016/S0140-6736(11)60679-X Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. doi:10.​1016/​S0140-6736(11)60679-X
go back to reference Derave W, Hansen BF, Lund S, Kristiansen S, Richter EA (2000) Muscle glycogen content affects insulin-stimulated glucose transport and protein kinase B activity. Am J Physiol Endocrinol Metab 279(5):E947–E955PubMed Derave W, Hansen BF, Lund S, Kristiansen S, Richter EA (2000) Muscle glycogen content affects insulin-stimulated glucose transport and protein kinase B activity. Am J Physiol Endocrinol Metab 279(5):E947–E955PubMed
go back to reference Esbjornsson-Liljedahl M, Sundberg CJ, Norman B, Jansson E (1999) Metabolic response in type I and type II muscle fibers during a 30-s cycle sprint in men and women. J Appl Physiol 87(4):1326–1332PubMed Esbjornsson-Liljedahl M, Sundberg CJ, Norman B, Jansson E (1999) Metabolic response in type I and type II muscle fibers during a 30-s cycle sprint in men and women. J Appl Physiol 87(4):1326–1332PubMed
go back to reference Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP (2011) Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43(7):1334–1359. doi:10.1249/MSS.0b013e318213fefb PubMedCrossRef Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP (2011) Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43(7):1334–1359. doi:10.​1249/​MSS.​0b013e318213fefb​ PubMedCrossRef
go back to reference Gearhart RF Jr, Becque MD, Palm CM, Hutchins MD (2005) Rating perceived exertion during short duration, very high intensity cycle exercise. Percept Mot Skills 100(3 Pt 1):767–773PubMedCrossRef Gearhart RF Jr, Becque MD, Palm CM, Hutchins MD (2005) Rating perceived exertion during short duration, very high intensity cycle exercise. Percept Mot Skills 100(3 Pt 1):767–773PubMedCrossRef
go back to reference Gibala MJ, Little JP, van Essen M, Wilkin GP, Burgomaster KA, Safdar A, Raha S, Tarnopolsky MA (2006) Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol 575(Pt 3):901–911. doi:10.1113/jphysiol.2006.112094 PubMedCrossRef Gibala MJ, Little JP, van Essen M, Wilkin GP, Burgomaster KA, Safdar A, Raha S, Tarnopolsky MA (2006) Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol 575(Pt 3):901–911. doi:10.​1113/​jphysiol.​2006.​112094 PubMedCrossRef
go back to reference Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M (2009) Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1 alpha in human skeletal muscle. J Appl Physiol 106(3):929–934. doi:10.1152/japplphysiol.90880.2008 PubMedCrossRef Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M (2009) Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1 alpha in human skeletal muscle. J Appl Physiol 106(3):929–934. doi:10.​1152/​japplphysiol.​90880.​2008 PubMedCrossRef
go back to reference Jensen J, Jebens E, Brennesvik EO, Ruzzin J, Soos MA, Engebretsen EM, O’Rahilly S, Whitehead JP (2006) Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling. Am J Physiol Endocrinol Metab 290(1):E154–E162. doi:10.1152/ajpendo.00330.2005 PubMedCrossRef Jensen J, Jebens E, Brennesvik EO, Ruzzin J, Soos MA, Engebretsen EM, O’Rahilly S, Whitehead JP (2006) Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling. Am J Physiol Endocrinol Metab 290(1):E154–E162. doi:10.​1152/​ajpendo.​00330.​2005 PubMedCrossRef
go back to reference Kawanaka K, Nolte LA, Han DH, Hansen PA, Holloszy JO (2000) Mechanisms underlying impaired GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats. Am J Physiol Endocrinol Metab 279(6):E1311–E1318PubMed Kawanaka K, Nolte LA, Han DH, Hansen PA, Holloszy JO (2000) Mechanisms underlying impaired GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats. Am J Physiol Endocrinol Metab 279(6):E1311–E1318PubMed
go back to reference Laurent D, Hundal RS, Dresner A, Price TB, Vogel SM, Petersen KF, Shulman GI (2000) Mechanism of muscle glycogen autoregulation in humans. Am J Physiol Endocrinol Metab 278(4):E663–E668PubMed Laurent D, Hundal RS, Dresner A, Price TB, Vogel SM, Petersen KF, Shulman GI (2000) Mechanism of muscle glycogen autoregulation in humans. Am J Physiol Endocrinol Metab 278(4):E663–E668PubMed
go back to reference Little JP, Gillen JB, Percival M, Safdar A, Tarnopolsky MA, Punthakee Z, Jung ME, Gibala MJ (2011) Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol. doi:10.1152/japplphysiol.00921.2011 Little JP, Gillen JB, Percival M, Safdar A, Tarnopolsky MA, Punthakee Z, Jung ME, Gibala MJ (2011) Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol. doi:10.​1152/​japplphysiol.​00921.​2011
go back to reference Parolin ML, Chesley A, Matsos MP, Spriet LL, Jones NL, Heigenhauser GJ (1999) Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. Am J Physiol 277(5 Pt 1):E890–E900PubMed Parolin ML, Chesley A, Matsos MP, Spriet LL, Jones NL, Heigenhauser GJ (1999) Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. Am J Physiol 277(5 Pt 1):E890–E900PubMed
go back to reference Piche ME, Lemieux S, Corneau L, Nadeau A, Bergeron J, Weisnagel SJ (2007) Measuring insulin sensitivity in postmenopausal women covering a range of glucose tolerance: comparison of indices derived from the oral glucose tolerance test with the euglycemic–hyperinsulinemic clamp. Metabolism 56(9):1159–1166. doi:10.1016/j.metabol.2007.04.002 PubMedCrossRef Piche ME, Lemieux S, Corneau L, Nadeau A, Bergeron J, Weisnagel SJ (2007) Measuring insulin sensitivity in postmenopausal women covering a range of glucose tolerance: comparison of indices derived from the oral glucose tolerance test with the euglycemic–hyperinsulinemic clamp. Metabolism 56(9):1159–1166. doi:10.​1016/​j.​metabol.​2007.​04.​002 PubMedCrossRef
go back to reference Rakobowchuk M, Tanguay S, Burgomaster KA, Howarth KR, Gibala MJ, MacDonald MJ (2008) Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol 295(1):R236–R242. doi:10.1152/ajpregu.00069.2008 PubMedCrossRef Rakobowchuk M, Tanguay S, Burgomaster KA, Howarth KR, Gibala MJ, MacDonald MJ (2008) Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol 295(1):R236–R242. doi:10.​1152/​ajpregu.​00069.​2008 PubMedCrossRef
go back to reference Richards JC, Johnson TK, Kuzma JN, Lonac MC, Schweder MM, Voyles WF, Bell C (2010) Short-term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to beta-adrenergic stimulation. J Physiol 588(Pt 15):2961–2972. doi:10.1113/jphysiol.2010.189886 PubMedCrossRef Richards JC, Johnson TK, Kuzma JN, Lonac MC, Schweder MM, Voyles WF, Bell C (2010) Short-term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to beta-adrenergic stimulation. J Physiol 588(Pt 15):2961–2972. doi:10.​1113/​jphysiol.​2010.​189886 PubMedCrossRef
go back to reference Richter EA, Derave W, Wojtaszewski JF (2001) Glucose, exercise and insulin: emerging concepts. J Physiol 535(Pt 2):313–322 pii: PHY_12798PubMedCrossRef Richter EA, Derave W, Wojtaszewski JF (2001) Glucose, exercise and insulin: emerging concepts. J Physiol 535(Pt 2):313–322 pii: PHY_12798PubMedCrossRef
go back to reference Steinberg GR, Watt MJ, McGee SL, Chan S, Hargreaves M, Febbraio MA, Stapleton D, Kemp BE (2006) Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle. Appl Physiol Nutr Metab 31(3):302–312. doi:10.1139/h06-003 PubMedCrossRef Steinberg GR, Watt MJ, McGee SL, Chan S, Hargreaves M, Febbraio MA, Stapleton D, Kemp BE (2006) Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle. Appl Physiol Nutr Metab 31(3):302–312. doi:10.​1139/​h06-003 PubMedCrossRef
go back to reference Thomas S, Reading J, Shephard RJ (1992) Revision of the physical-activity readiness questionnaire (PAR-Q). Can J Sport Sci Revue Canadienne Des Sci Du Sport 17(4):338–345 Thomas S, Reading J, Shephard RJ (1992) Revision of the physical-activity readiness questionnaire (PAR-Q). Can J Sport Sci Revue Canadienne Des Sci Du Sport 17(4):338–345
go back to reference Trilk JL, Singhal A, Bigelman KA, Cureton KJ (2010) Effect of sprint interval training on circulatory function during exercise in sedentary, overweight/obese women. Eur J Appl Physiol. doi:10.1007/s00421-010-1777-z Trilk JL, Singhal A, Bigelman KA, Cureton KJ (2010) Effect of sprint interval training on circulatory function during exercise in sedentary, overweight/obese women. Eur J Appl Physiol. doi:10.​1007/​s00421-010-1777-z
go back to reference Vollaard NB, Constantin-Teodosiu D, Fredriksson K, Rooyackers O, Jansson E, Greenhaff PL, Timmons JA, Sundberg CJ (2009) Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance. J Appl Physiol 106(5):1479–1486. doi:10.1152/japplphysiol.91453.2008 PubMedCrossRef Vollaard NB, Constantin-Teodosiu D, Fredriksson K, Rooyackers O, Jansson E, Greenhaff PL, Timmons JA, Sundberg CJ (2009) Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance. J Appl Physiol 106(5):1479–1486. doi:10.​1152/​japplphysiol.​91453.​2008 PubMedCrossRef
go back to reference Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS Jr, Blair SN (1999) Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 282(16):1547–1553 pii: joc90699PubMedCrossRef Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS Jr, Blair SN (1999) Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 282(16):1547–1553 pii: joc90699PubMedCrossRef
Metadata
Title
Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training
Authors
Richard S. Metcalfe
John A. Babraj
Samantha G. Fawkner
Niels B. J. Vollaard
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
European Journal of Applied Physiology / Issue 7/2012
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-011-2254-z

Other articles of this Issue 7/2012

European Journal of Applied Physiology 7/2012 Go to the issue