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01-03-2012 | Original Article

Muscle ceramide content is similar after 3 weeks’ consumption of fat or carbohydrate diet in a crossover design in patients with type 2 diabetes

Authors: J. W. Helge, L. Tobin, T. Drachmann, L. I. Hellgren, F. Dela, H. Galbo

Published in: European Journal of Applied Physiology | Issue 3/2012

Abstract

This study aimed at investigating the effect of prolonged adaptation to fat- or carbohydrate-rich diet on muscle ceramide in type 2 diabetes patients, using a longitudinal crossover study. Eleven type 2 diabetes patients consumed isocaloric fat- or carbohydrate-rich diet for 3 weeks in random order. After each dietary intervention period, muscle glycogen, triacylglycerol and ceramide content and plasma concentrations of insulin, adiponectin, glucose and FFA were determined. Insulin resistance was assessed by HOMA2 calculation. After the dietary period, plasma glucose and insulin, insulin sensitivity, muscle glycogen, triacylglycerol and ceramide content were similar. Plasma adiponectin concentration was significantly higher after fat compared with carbohydrate-rich diet. Results indicated that following fat-rich diet intake muscle ceramide and triacylglycerol concentrations were not different compared with that after carbohydrate-rich diet. Furthermore, plasma adiponectin concentration was higher after fat-rich compared with carbohydrate-rich diet, but insulin sensitivity remained similar despite the major difference in dietary macronutrient composition.

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Title: Muscle ceramide content is similar after 3 weeks’ consumption of fat or carbohydrate diet in a crossover design in patients with type 2 diabetes
Authors: J. W. Helge
L. Tobin
T. Drachmann
L. I. Hellgren
F. Dela
H. Galbo
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 3/2012
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-011-2041-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Muscle ceramide content is similar after 3 weeks’ consumption of fat or carbohydrate diet in a crossover design in patients with type 2 diabetes

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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