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01-07-2011 | Original Article

Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress

Authors: Iman Laziz, Arnaud Ferry, Anne-Sophie Armand, Claude Louis Gallien, Bruno Della Gaspera, F. Charbonnier, C. Chanoine

Published in: European Journal of Applied Physiology | Issue 7/2011

Abstract

The objective of this report was to analyse a potential role for FGF6 in muscle resistance to mechanical stress. Normal or regenerating muscles of FGF6 (−/−) mice versus wild-type mice were submitted to different protocols of damaging eccentric contractions (eccentric electrostimulation and intermittent downhill exercise). Then muscular structural properties were analysed by histological and immunochemistry techniques to evaluate the post-injury muscle recovery; their muscle contractile parameters (maximal tetanic force, kinetics properties and fatigue resistance) were assessed. The absence of FGF6 causes (1) a fast-to-slow myofibre type switch in adult control and regenerating Tibialis anterior (TA) muscle; (2) muscle weakness in regenerating muscles in animals submitted to eccentric exercise protocols due to aberrant extensive necrotic zones. These observations point out a crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress.

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Title: Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress
Authors: Iman Laziz
Arnaud Ferry
Anne-Sophie Armand
Claude Louis Gallien
Bruno Della Gaspera
F. Charbonnier
C. Chanoine
Publication date: 01-07-2011
Publisher: Springer-Verlag
Published in: European Journal of Applied Physiology / Issue 7/2011
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-010-1784-0

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