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European Journal of Applied Physiology
Published in: European Journal of Applied Physiology 5/2010

Open Access 01-03-2010 | Invited Review

Impact of inactivity and exercise on the vasculature in humans

Authors: Dick H. J. Thijssen, Andrew J. Maiorana, Gerry O’Driscoll, Nigel T. Cable, Maria T. E. Hopman, Daniel J. Green

Published in: European Journal of Applied Physiology | Issue 5/2010

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Abstract

The effects of inactivity and exercise training on established and novel cardiovascular risk factors are relatively modest and do not account for the impact of inactivity and exercise on vascular risk. We examine evidence that inactivity and exercise have direct effects on both vasculature function and structure in humans. Physical deconditioning is associated with enhanced vasoconstrictor tone and has profound and rapid effects on arterial remodelling in both large and smaller arteries. Evidence for an effect of deconditioning on vasodilator function is less consistent. Studies of the impact of exercise training suggest that both functional and structural remodelling adaptations occur and that the magnitude and time-course of these changes depends upon training duration and intensity and the vessel beds involved. Inactivity and exercise have direct “vascular deconditioning and conditioning” effects which likely modify cardiovascular risk.
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Metadata
Title
Impact of inactivity and exercise on the vasculature in humans
Authors
Dick H. J. Thijssen
Andrew J. Maiorana
Gerry O’Driscoll
Nigel T. Cable
Maria T. E. Hopman
Daniel J. Green
Publication date
01-03-2010
Publisher
Springer-Verlag
Published in
European Journal of Applied Physiology / Issue 5/2010
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-009-1260-x

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