Skip to main content
Top
Published in: European Journal of Applied Physiology 1-2/2004

01-10-2004 | Original Article

Exercise capacity in young adults with hypertension and systolic blood pressure difference between right arm and leg after repair of coarctation of the aorta

Authors: Arne Instebø, Gunnar Norgård, Vegard Helgheim, Ola Drange Røksund, Leidulf Segadal, Gottfried Greve

Published in: European Journal of Applied Physiology | Issue 1-2/2004

Login to get access

Abstract

Coarctation of the aorta represents 5–7% of congenital heart defects. Symptoms and prognosis depend on the degree of stenosis, age at surgery, surgical method and the presence of other heart defects. Postoperative complications are hypertension, restenosis and an abnormal blood pressure response during exercise. This study includes 41 patients, 15–40 years old, operated in the period 1975–1996. All were exercised on a treadmill until maximal oxygen consumption was achieved. Blood pressure was measured in the right arm and leg before and immediately after exercise, and in the right arm during exercise. Oxygen consumption was monitored and we defined an aerobic phase, an isocapnic buffering phase and a hypocapnic hyperventilation phase. The resting systolic blood pressure correlates with the resting systolic blood pressure difference between right arm and leg. A resting systolic blood pressure difference between the right arm and leg of 0.13 kPa (1 mmHg) to 2.67 kPa (20 mmHg) corresponds with a slight increase in resting systolic blood pressure. This rise in blood pressure increases the aerobic phase of the exercise test, helping the patients to achieve higher maximal oxygen consumption. A resting systolic blood pressure difference of more than 2.67 kPa (20 mmHg) corresponds with severe hypertension and causes reduction in the aerobic phase and maximal oxygen consumption. Resting systolic blood pressure and resting systolic blood pressure difference between the right arm and leg are not indicators for blood pressure response during exercise. Exercise testing is important to reveal exercise-induced hypertension and to monitor changes in transition from aerobic to anaerobic exercise and limitation to exercise capacity.
Literature
go back to reference Allen HD, Beekman RH, Garson A Jr. Hijazi ZM, Mullins C, O’Laughlin, Taubert KA (1998) Pediatric therapeutic cardiac catheterization. A statement for healthcare professionals from the council on cardiovascular disease in the young, American Heart Association. Circulation 97:609–625PubMed Allen HD, Beekman RH, Garson A Jr. Hijazi ZM, Mullins C, O’Laughlin, Taubert KA (1998) Pediatric therapeutic cardiac catheterization. A statement for healthcare professionals from the council on cardiovascular disease in the young, American Heart Association. Circulation 97:609–625PubMed
go back to reference Alpert BS, Bain HH, Balfe JW, Kidd BS, Olley PM (1979) Role of the renin–angiotensin–aldosterone system in hypertensive children with coarctation of the aorta. Am J Cardiol 43:828–834CrossRefPubMed Alpert BS, Bain HH, Balfe JW, Kidd BS, Olley PM (1979) Role of the renin–angiotensin–aldosterone system in hypertensive children with coarctation of the aorta. Am J Cardiol 43:828–834CrossRefPubMed
go back to reference Beaver WL, Wasserman K, Whipp BJ (1986) A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60:2020–2027PubMed Beaver WL, Wasserman K, Whipp BJ (1986) A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60:2020–2027PubMed
go back to reference Bharati S, Lev M (1986) The surgical anatomy of the heart in tubular hypoplasia of the transverse aorta (preductal coarctation). J Thorac Cardiovasc Surg 91:79–85PubMed Bharati S, Lev M (1986) The surgical anatomy of the heart in tubular hypoplasia of the transverse aorta (preductal coarctation). J Thorac Cardiovasc Surg 91:79–85PubMed
go back to reference Borow KM, Colan SD, Neumann A (1985) Altered left ventricular mechanics in patients with valvular aortic stenosis and coarction of the aorta: effects on systolic performance and late outcome. Circulation 72:515–522PubMed Borow KM, Colan SD, Neumann A (1985) Altered left ventricular mechanics in patients with valvular aortic stenosis and coarction of the aorta: effects on systolic performance and late outcome. Circulation 72:515–522PubMed
go back to reference Clarkson PM, Nicholson MR, Barratt-Boyes BG, Neutze JM, Whitlock RM (1983) Results after repair of coarctation of the aorta beyond infancy: a 10 to 28 year follow-up with particular reference to late systemic hypertension. Am J Cardiol 51(9):1481–1488PubMed Clarkson PM, Nicholson MR, Barratt-Boyes BG, Neutze JM, Whitlock RM (1983) Results after repair of coarctation of the aorta beyond infancy: a 10 to 28 year follow-up with particular reference to late systemic hypertension. Am J Cardiol 51(9):1481–1488PubMed
go back to reference Engvall J, Karlsson M, Ask P, Loyd D, Nylander E, Wranne B (1994) Importance of collateral vessels in aortic coarctation: computer simulation at rest and exercise using transmission line elements. Med Biol Eng Comput 32[Suppl 4]:S115–122 Engvall J, Karlsson M, Ask P, Loyd D, Nylander E, Wranne B (1994) Importance of collateral vessels in aortic coarctation: computer simulation at rest and exercise using transmission line elements. Med Biol Eng Comput 32[Suppl 4]:S115–122
go back to reference Engvall J, Sonnhag C, Nylander E, Stenport G, Karlsson E, Wranne B (1995) Arm–ankle systolic blood pressure difference at rest and after exercise in the assessment of aortic coarctation. Br Heart J 73:270–276PubMed Engvall J, Sonnhag C, Nylander E, Stenport G, Karlsson E, Wranne B (1995) Arm–ankle systolic blood pressure difference at rest and after exercise in the assessment of aortic coarctation. Br Heart J 73:270–276PubMed
go back to reference Gardiner HM, Celermajer DS, Sorensen KE, Georgakopoulos D, Robinson J, Thomas O, Deanfield JE (1994) Arterial reactivity is significantly impaired in normotensive young adults after successful repair of aortic coarctation in childhood. Circulation 89:1745–1750PubMed Gardiner HM, Celermajer DS, Sorensen KE, Georgakopoulos D, Robinson J, Thomas O, Deanfield JE (1994) Arterial reactivity is significantly impaired in normotensive young adults after successful repair of aortic coarctation in childhood. Circulation 89:1745–1750PubMed
go back to reference Griffin SE, Robergs RA, Heyward VH (1997) Blood pressure measurement during exercise: a review. Med Sci Sports Exerc 29:149–159PubMed Griffin SE, Robergs RA, Heyward VH (1997) Blood pressure measurement during exercise: a review. Med Sci Sports Exerc 29:149–159PubMed
go back to reference Guenthard J, Wyler F (1995) Exercise-induced hypertension in the arms due to impaired arterial reactivity after successful coarctation resection. Am J Cardiol 75:814–817CrossRef Guenthard J, Wyler F (1995) Exercise-induced hypertension in the arms due to impaired arterial reactivity after successful coarctation resection. Am J Cardiol 75:814–817CrossRef
go back to reference Guenthard J, Wyler F (1996) Doppler echocardiography during exercise to predict residual narrowing of the aorta after coarctation resection. Pediatr Cardiol 17:370–374CrossRefPubMed Guenthard J, Wyler F (1996) Doppler echocardiography during exercise to predict residual narrowing of the aorta after coarctation resection. Pediatr Cardiol 17:370–374CrossRefPubMed
go back to reference Guenthard J, Zumsteg U, Wyler F (1996) Arm–leg pressure gradients on late follow-up after coarctation repair. Possible causes and implications. Eur Heart J 17:1572–1575PubMed Guenthard J, Zumsteg U, Wyler F (1996) Arm–leg pressure gradients on late follow-up after coarctation repair. Possible causes and implications. Eur Heart J 17:1572–1575PubMed
go back to reference Kaemmerer H, Oelert F, Bahlmann J, Blucher S, Meyer GP, Mugge A (1998) Arterial hypertension in adults after surgical treatment of aortic coarctation. Thorac Cardiovasc Surg 46:121–125PubMed Kaemmerer H, Oelert F, Bahlmann J, Blucher S, Meyer GP, Mugge A (1998) Arterial hypertension in adults after surgical treatment of aortic coarctation. Thorac Cardiovasc Surg 46:121–125PubMed
go back to reference Kappetein PA, Guit GL, Bogers AJ, Weeda HW, Zwinderman KH, Schonberger JP, Huysmans HA (1993) Noninvasive long-term follow-up after coarctation repair. Ann Thorac Surg 55:1153–1159PubMed Kappetein PA, Guit GL, Bogers AJ, Weeda HW, Zwinderman KH, Schonberger JP, Huysmans HA (1993) Noninvasive long-term follow-up after coarctation repair. Ann Thorac Surg 55:1153–1159PubMed
go back to reference Kimball TR, Reynolds JM, Mays WA, Khoury P, Claytor RP, Daniels SR (1994) Persistent hyperdynamic cardiovascular state at rest and during exercise in children after successful repair of coarctation of the aorta. J Am Coll Cardiol 24:194–200PubMed Kimball TR, Reynolds JM, Mays WA, Khoury P, Claytor RP, Daniels SR (1994) Persistent hyperdynamic cardiovascular state at rest and during exercise in children after successful repair of coarctation of the aorta. J Am Coll Cardiol 24:194–200PubMed
go back to reference Krogmann ON, Kramer HH, Rammos S, Heusch A, Bourgeois M (1993) Non-invasive evaluation of left ventricular systolic function late after coarctation repair: influence of early vs late surgery. Eur Heart J 14:764–769PubMed Krogmann ON, Kramer HH, Rammos S, Heusch A, Bourgeois M (1993) Non-invasive evaluation of left ventricular systolic function late after coarctation repair: influence of early vs late surgery. Eur Heart J 14:764–769PubMed
go back to reference Leandro J, Smallhorn JF, Benson L, Musewe N, Balfe JW, Dyck JD, West L, Freedom R (1992) Ambulatory blood pressure monitoring and left ventricular mass and function after successful surgical repair of coarctation of the aorta. J Am Coll Cardiol 20:197–204PubMed Leandro J, Smallhorn JF, Benson L, Musewe N, Balfe JW, Dyck JD, West L, Freedom R (1992) Ambulatory blood pressure monitoring and left ventricular mass and function after successful surgical repair of coarctation of the aorta. J Am Coll Cardiol 20:197–204PubMed
go back to reference Markel H, Rocchini AP, Beekman RH, Martin J, Palmisano J, Moorehead C, Rosenthal A (1986) Exercise-induced hypertension after repair of coarctation of the aorta: arm versus leg exercise. J Am Coll Cardiol 8:165–171PubMed Markel H, Rocchini AP, Beekman RH, Martin J, Palmisano J, Moorehead C, Rosenthal A (1986) Exercise-induced hypertension after repair of coarctation of the aorta: arm versus leg exercise. J Am Coll Cardiol 8:165–171PubMed
go back to reference Moskowitz WB, Schieken RM, Mosteller M, Bossano R (1990) Altered systolic and diastolic function in children after “successful” repair of coarctation of the aorta. Am Heart J 120:103–109CrossRefPubMed Moskowitz WB, Schieken RM, Mosteller M, Bossano R (1990) Altered systolic and diastolic function in children after “successful” repair of coarctation of the aorta. Am Heart J 120:103–109CrossRefPubMed
go back to reference Ong CM, Canter CE, Gutierrez FR, Sekarski DR, Goldring DR (1992) Increased stiffness and persistent narrowing of the aorta after successful repair of coarctation of the aorta: relationship to left ventricular mass and blood pressure at rest and with exercise. Am Heart J 123:1594–1600CrossRefPubMed Ong CM, Canter CE, Gutierrez FR, Sekarski DR, Goldring DR (1992) Increased stiffness and persistent narrowing of the aorta after successful repair of coarctation of the aorta: relationship to left ventricular mass and blood pressure at rest and with exercise. Am Heart J 123:1594–1600CrossRefPubMed
go back to reference Oshima Y, Miyamoto T, Tanaka S, Wadazumi T, Kurihara N, Fujimoto S (1997) Relationship between isocapnic buffering and maximal aerobic capacity in athletes. Eur J Appl Physiol 76:409–414CrossRef Oshima Y, Miyamoto T, Tanaka S, Wadazumi T, Kurihara N, Fujimoto S (1997) Relationship between isocapnic buffering and maximal aerobic capacity in athletes. Eur J Appl Physiol 76:409–414CrossRef
go back to reference Palatini P, Bongiovi S, Mario L, Schiraldi C, Mos L, Pessina AC (1995) Above-normal left ventricular systolic performance during exercise in young subjects with mild hypertension. Eur Heart J 16:232–242PubMed Palatini P, Bongiovi S, Mario L, Schiraldi C, Mos L, Pessina AC (1995) Above-normal left ventricular systolic performance during exercise in young subjects with mild hypertension. Eur Heart J 16:232–242PubMed
go back to reference Parker FB, Farrell B, Streeten DH, Blackman MS, Sondheimer HM, Anderson GH (1980) Hypertensive mechanisms in coarctation of the aorta. Further studies of the renin-angiotensin system. J Thorac Cardiovasc Surg 80:568–573PubMed Parker FB, Farrell B, Streeten DH, Blackman MS, Sondheimer HM, Anderson GH (1980) Hypertensive mechanisms in coarctation of the aorta. Further studies of the renin-angiotensin system. J Thorac Cardiovasc Surg 80:568–573PubMed
go back to reference Parker FB, Streeten DH, Farrell B, Blackman MS, Sondheimer HM, Anderson GH (1982) Preoperative and postoperative renin levels in coarctation of the aorta. Circulation 66:513–514PubMed Parker FB, Streeten DH, Farrell B, Blackman MS, Sondheimer HM, Anderson GH (1982) Preoperative and postoperative renin levels in coarctation of the aorta. Circulation 66:513–514PubMed
go back to reference Presbitero P, Demarie D, Villani M, Perinetto EA, Riva G, Orzan F, Bobbio M, Morea M, Brusca A (1987) Long term results (15–30 years) of surgical repair of aortic coarctation. Br Heart J 57:462–467PubMed Presbitero P, Demarie D, Villani M, Perinetto EA, Riva G, Orzan F, Bobbio M, Morea M, Brusca A (1987) Long term results (15–30 years) of surgical repair of aortic coarctation. Br Heart J 57:462–467PubMed
go back to reference Quaegebeur JM, Jonas RA, Weinberg AD, Blackstone EH, Kirklin JW (1994) Outcomes in seriously ill neonates with coarctation of the aorta. A multiinstitutional study. J Thorac Cardiovasc Surg 108:841–851PubMed Quaegebeur JM, Jonas RA, Weinberg AD, Blackstone EH, Kirklin JW (1994) Outcomes in seriously ill neonates with coarctation of the aorta. A multiinstitutional study. J Thorac Cardiovasc Surg 108:841–851PubMed
go back to reference Rhodes J, Geggel RL, Marx GR, Bevilacqua L, Dambach YB, Hijazi ZM (1997) Excessive anaerobic metabolism during exercise after repair of aortic coarctation. J Pediatr 131:210–214PubMed Rhodes J, Geggel RL, Marx GR, Bevilacqua L, Dambach YB, Hijazi ZM (1997) Excessive anaerobic metabolism during exercise after repair of aortic coarctation. J Pediatr 131:210–214PubMed
go back to reference Sharma S, Maron BJ, Whyte G, Firoozi S, Elliott PM, McKenna WJ (2002) Physiologic limits of left ventricular hypertrophy in elite junior athletes: relevance to differential diagnosis of athlete’s heart and hypertrophic cardiomyopathy. J Am Coll Cardiol 40(8):1431–1436CrossRefPubMed Sharma S, Maron BJ, Whyte G, Firoozi S, Elliott PM, McKenna WJ (2002) Physiologic limits of left ventricular hypertrophy in elite junior athletes: relevance to differential diagnosis of athlete’s heart and hypertrophic cardiomyopathy. J Am Coll Cardiol 40(8):1431–1436CrossRefPubMed
go back to reference Sigurdardottir LY, Helgason H (1996) Exercise-induced hypertension after corrective surgery for coarctation of the aorta. Pediatr Cardiol 17:301–307CrossRefPubMed Sigurdardottir LY, Helgason H (1996) Exercise-induced hypertension after corrective surgery for coarctation of the aorta. Pediatr Cardiol 17:301–307CrossRefPubMed
go back to reference Stewart AB, Ahmed R, Travill CM, Newman CG (1993) Coarctation of the aorta life and health 20–44 years after surgical repair. Br Heart J 69:65–70PubMed Stewart AB, Ahmed R, Travill CM, Newman CG (1993) Coarctation of the aorta life and health 20–44 years after surgical repair. Br Heart J 69:65–70PubMed
go back to reference Tantengco MV, Ross RD, Humes RA, Sullivan NM, Joshi VM, Clapp SK, Epstein ML (1997) Enhanced resting left ventricular filling in patients with successful coarctation repair and exercise-induced hypertension. Am Heart J 134:1082–1088PubMed Tantengco MV, Ross RD, Humes RA, Sullivan NM, Joshi VM, Clapp SK, Epstein ML (1997) Enhanced resting left ventricular filling in patients with successful coarctation repair and exercise-induced hypertension. Am Heart J 134:1082–1088PubMed
go back to reference Thu K, Segadal L, Kvitting P, Greve G (1999) Patients surgically treated for aortic coarctation. Tidsskr Nor Laegeforen 119:2162–2165PubMed Thu K, Segadal L, Kvitting P, Greve G (1999) Patients surgically treated for aortic coarctation. Tidsskr Nor Laegeforen 119:2162–2165PubMed
go back to reference Wasserman K, Stringer WW, Casaburi R, Koike A, Cooper CB (1994) Determination of the anaerobic threshold by gas exchange: biochemical considerations, methodology and physiological effects. Z Kardiol 83[Suppl 3]:1–12 Wasserman K, Stringer WW, Casaburi R, Koike A, Cooper CB (1994) Determination of the anaerobic threshold by gas exchange: biochemical considerations, methodology and physiological effects. Z Kardiol 83[Suppl 3]:1–12
go back to reference Weber HS, Cyran SE, Grzeszczak M, Myers JL, Gleason MM, Baylen BG (1993) Discrepancies in aortic growth explain aortic arch gradients during exercise. J Am Coll Cardiol 21:1002–1007PubMed Weber HS, Cyran SE, Grzeszczak M, Myers JL, Gleason MM, Baylen BG (1993) Discrepancies in aortic growth explain aortic arch gradients during exercise. J Am Coll Cardiol 21:1002–1007PubMed
go back to reference Wendel H, Teien D, Human DG, Nanton MA (1992) Assessment of blood pressures and gradients by automated blood pressure device compared to invasive measurements in patients previously operated on for coarctation of the aorta. Clin Physiol 12:155–162PubMed Wendel H, Teien D, Human DG, Nanton MA (1992) Assessment of blood pressures and gradients by automated blood pressure device compared to invasive measurements in patients previously operated on for coarctation of the aorta. Clin Physiol 12:155–162PubMed
go back to reference Wu JL, Leung MP, Karlberg J, Chiu C, Lee J, Mok CK (1995) Surgical repair of coarctation of the aorta in neonates: factors affecting early mortality and re-coarctation. Cardiovasc Surg 3:573–578CrossRefPubMed Wu JL, Leung MP, Karlberg J, Chiu C, Lee J, Mok CK (1995) Surgical repair of coarctation of the aorta in neonates: factors affecting early mortality and re-coarctation. Cardiovasc Surg 3:573–578CrossRefPubMed
Metadata
Title
Exercise capacity in young adults with hypertension and systolic blood pressure difference between right arm and leg after repair of coarctation of the aorta
Authors
Arne Instebø
Gunnar Norgård
Vegard Helgheim
Ola Drange Røksund
Leidulf Segadal
Gottfried Greve
Publication date
01-10-2004
Publisher
Springer-Verlag
Published in
European Journal of Applied Physiology / Issue 1-2/2004
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-004-1180-8

Other articles of this Issue 1-2/2004

European Journal of Applied Physiology 1-2/2004 Go to the issue