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Published in: International Archives of Occupational and Environmental Health 8/2019

Open Access 01-11-2019 | Original Article

Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz

Authors: Håkan Westberg, Alexander Hedbrant, Alexander Persson, Ing-Liss Bryngelsson, Anders Johansson, Annette Ericsson, Bengt Sjögren, Leo Stockfelt, Eva Särndahl, Lena Andersson

Published in: International Archives of Occupational and Environmental Health | Issue 8/2019

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Abstract

Purpose

To study the relationship between inhalation of airborne particles and quartz in Swedish iron foundries and markers of inflammation and coagulation in blood.

Methods

Personal sampling of respirable dust and quartz was performed for 85 subjects in three Swedish iron foundries. Stationary measurements were used to study the concentrations of respirable dust and quartz, inhalable and total dust, PM10 and PM2.5, as well as the particle surface area and the particle number concentrations. Markers of inflammation, namely interleukins (IL-1β, IL-6, IL-8, IL-10 and IL-12), C-reactive protein, and serum amyloid A (SAA) were measured in plasma or serum, together with markers of coagulation including fibrinogen, factor VIII (FVIII), von Willebrand factor and d-dimer. Complete sampling was performed on the second or third day of a working week after a work-free weekend, and follow-up samples were collected 2 days later. A mixed model analysis was performed including sex, age, smoking, infections, blood group, sampling day and BMI as covariates.

Results

The average 8-h time-weighted average air concentrations of respirable dust and quartz were 0.85 mg/m3 and 0.052 mg/m3, respectively. Participants in high-exposure groups with respect to some of the measured particle types exhibited significantly elevated levels of SAA, fibrinogen and FVIII.

Conclusions

These observed relationships between particle exposure and inflammatory markers may indicate an increased risk of cardiovascular disease among foundry workers with high particulate exposure.
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Metadata
Title
Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz
Authors
Håkan Westberg
Alexander Hedbrant
Alexander Persson
Ing-Liss Bryngelsson
Anders Johansson
Annette Ericsson
Bengt Sjögren
Leo Stockfelt
Eva Särndahl
Lena Andersson
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
International Archives of Occupational and Environmental Health / Issue 8/2019
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI
https://doi.org/10.1007/s00420-019-01446-z

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