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International Archives of Occupational and Environmental Health

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01-02-2010 | Original Article

Nasal blown secretion evaluation in specific occupational nasal challenges

Authors: Patrizia Pignatti, Gianni Pala, Marta Pisati, Luca Perfetti, Gabriella Banchieri, Gianna Moscato

Published in: International Archives of Occupational and Environmental Health | Issue 2/2010

Abstract

Purpose

To investigate the usefulness of nasal blown secretion evaluation during specific nasal provocation test (sNPT) in diagnosing occupational rhinitis (OR).

Methods

To validate the method, nasal blown secretions from 103 healthy subjects and 30 allergic rhinitis patients were analyzed. Furthermore, we analyzed nasal blown secretions, collected before and after sNPT, of 29 subjects with work-related rhinitis symptoms (WRRS) who underwent the diagnostic pathway for OR. Rhinoscopy and nasal symptom score were used to define a positive sNPT.

Results

A total of 89.6% WRRS subjects provided suitable nasal secretions. Eosinophils significantly increased after positive sNPTs compared to negative ones (P = 0.006). Four percent and/or 1 × 10⁴ eosinophils/ml was the cut-off for a significant post-sNPT eosinophil increase. A total of 4/13 (33%) WRRS subjects with negative sNPT, assessed by rhinoscopy and nasal symptom score, presented a significant post-sNPT nasal eosinophil increase, and were identified as possible OR.

Conclusion

Eosinophil evaluation in nasal blown secretions is an important tool in monitoring the response to occupational specific nasal challenges.

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Title: Nasal blown secretion evaluation in specific occupational nasal challenges
Authors: Patrizia Pignatti
Gianni Pala
Marta Pisati
Luca Perfetti
Gabriella Banchieri
Gianna Moscato
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: International Archives of Occupational and Environmental Health / Issue 2/2010
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-009-0459-9

At a glance: The STEP trials

Springer Medicine

Nasal blown secretion evaluation in specific occupational nasal challenges

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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