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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 2/2021

01-02-2021 | Refractive Errors | Retinal Disorders

Does the number of laser applications for ROP treatment influence the degree of myopia?

Authors: Tatsuya Inoue, Ryo Asaoka, Yohei Hashimoto, Kohdai Kitamoto, Marie Kitano, Asahi Fujita, Keiko Azuma, Kazuhiro Yamamoto, Miyuki Nagahara, Kazuaki Kadonosono, Ryo Obata

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2021

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Abstract

Purpose

To evaluate the relationship between the number of laser shots applied during laser photocoagulation treatment and the degree of myopia at 3 years in children with laser-treated retinopathy of prematurity (ROP).

Method

A total of 68 eyes of 34 infants who had developed prethreshold ROP and were treated by diode laser therapy were included in the current study. Cycloplegic retinoscopic refraction testing was performed in the children at the age of 3 years, and the spherical equivalent (SE) was calculated for all the examined eyes. The number of laser shots that had been applied was compared between the eyes with and without high myopia (SE < − 5 diopters (D)). In addition, the relationship between the difference in the SE values between the two eyes in each infant and the difference in the number of laser shots applied between the two eyes was also analyzed.

Results

The number of laser shots applied was significantly higher for the eyes with high myopia than for those without high myopia (p = 0.0088), and the number of laser shots applied was significantly positively correlated with the degree of myopia (p < 0.001). A significant correlation was also observed between the differences in the SE values between the two eyes and the differences in the number of laser shots applied between the two eyes (p = 0.0013).

Conclusion

The number of laser shots applied in photocoagulation treatment for ROP is significantly associated with the degree of myopia seen subsequently in the children.
Literature
1.
Chen J, Stahl A, Hellstrom A et al (2011) Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr 23:173–178CrossRef
2.
Sapieha P, Joyal J, Rivera JC et al (2010) Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest 120:3022–3032CrossRef
3.
Cavallaro G, Filippi L, Bagnoli P et al (2014) The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge. Acta Ophthalmol 92:2–20CrossRef
4.
Shah PK, Prabhu V, Karandikar SS, Ranjan R et al (2016) Retinopathy of prematurity: past, present and future. World J Clin Pediatr 5:35–46CrossRef
5.
Axer-Siegel R, Maharshak I, Snir M et al (2008) Diode laser treatment of retinopathy of prematurity: anatomical and refractive outcomes. Retina 28:839–846CrossRef
6.
McLoone E, O'Keefe M, McLoone S et al (2006) Long term functional and structural outcomes of laser therapy for retinopathy of prematurity. Br J Ophthalmol 90:754–759CrossRef
7.
Early Treatment For Retinopathy Of Prematurity Cooperative G (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121:1684–1694CrossRef
8.
Quinn GE, Dobson V, Davitt BV et al (2008) Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age. Ophthalmology 115:1058–1064 e1051CrossRef
9.
Quinn GE, Dobson V, Davitt BV et al (2013) Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6 years of age. J AAPOS 17:124–128CrossRef
10.
Cotter SA, Pediatric Eye Disease Investigator Group (2006) Treatment of anisometropic amblyopia in children with refractive correction. Ophthalmology 113(6):895–903CrossRef
11.
Donahue SP, Arthur B et al (2013) AAPOS Vision Screening Committee. Guidelines for automated preschool vision screening: a 10-year, evidence-based update. J AAPOS 17:4–8CrossRef
12.
Baayen RH, Davidson DJ, Bates DM (2008) Mixed-effects modeling with crossed random effects for subjects and items. J Mem Lang 59:390–412CrossRef
13.
Bates D, Mächler M, Bolker BM, Walker SC (2015) Fitting linear mixed-effects models using lme4. J Stat Softw 67:1–48CrossRef
14.
Tibshirani RJ, Taylor J (2012) Degrees of freedom in lasso problems. Ann Stat 40:1198–1232CrossRef
15.
Mallows CL (1973) Some comments on C p. Technometrics 15:661–675
16.
Burnham KP, Anderson DR (2004) Multimodel inference: understanding AIC and BIC in model selection. Sociol Methods Res 33:261–304CrossRef
17.
Geloneck MM, Chuang AZ, Clark WL et al (2014) Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial. JAMA Ophthalmol 132:1327–1333CrossRef
18.
Hu J, Blair MP, Shapiro MJ et al (2012) Reactivation of retinopathy of prematurity after bevacizumab injection. Arch Ophthalmol 130:1000–1006CrossRef
19.
Mintz-Hittner HA, Kennedy KA, Chuang AZ, BEAT-ROP Cooperative Group (2011) Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med 364:603–615CrossRef
20.
Hwang CK, Hubbard GB, Hutchinson AK et al (2015) Outcomes after intravitreal bevacizumab versus laser photocoagulation for retinopathy of prematurity: a 5-year retrospective analysis. Ophthalmology 122(5):1008–1015CrossRef
21.
Fielder AR, Quinn GE (1997) Myopia of prematurity: nature, nurture, or disease? Br J Ophthalmol 81(1):2–3CrossRef
22.
Fledelius HC (1993) Retinopathy of prematurity in Frederiksborg County 1988-1990. A prospective investigation, an update. Acta Ophthalmol Suppl 210:59–62
Metadata
Title
Does the number of laser applications for ROP treatment influence the degree of myopia?
Authors
Tatsuya Inoue
Ryo Asaoka
Yohei Hashimoto
Kohdai Kitamoto
Marie Kitano
Asahi Fujita
Keiko Azuma
Kazuhiro Yamamoto
Miyuki Nagahara
Kazuaki Kadonosono
Ryo Obata
Publication date
01-02-2021
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2021
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-020-04946-8

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