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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-01-2021 | Refractive Errors | Retinal Disorders

Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis

Authors: Rosa M. Coco-Martin, Minal Belani-Raju, Daniel de la Fuente-Gomez, María R. Sanabria, Itziar Fernández

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2021

Abstract

Purpose

This study aims to determine the probability of progression of myopic maculopathy according to age.

Methods

This is a longitudinal observational study of single-center retrospective cohort of Caucasian patients formed by 212 consecutive adults with high myopia. Main outcome measures were age, visual acuity (VA), refractive error (RE), follow-up time, and the macular status assessed at least 5 years apart according to the Meta-Analysis of Pathologic Myopia Study Group. The progression rate was calculated based on per 1000 eyes/year. Multistate models were fitted to identify the predictive factors and to calculate the most probable age of progression onset using the Aalen–Johansen estimator.

Results

We studied 220 eyes of 122 Caucasian patients. Mean age was 48.18 ± 14.1, mean follow-up 12.73 ± 5.81 years. One-hundred and fifty-two (69.1%) eyes progressed of category, and 96 (44%) worsened a mean of 0.3 logMAR units during follow-up. The progression rate was 32.21/1000 eyes/year. The probability of progressing increased with age; it was higher in women if there was a family history of myopia, worse VA, higher RE, or wide macular staphyloma. The probability of progressing from category 1 was > 0.6 after 70 years of age; from category 2, it was 0.7 after 70 years; and 0.5 from category 3 after 75 years. If choroidal neovascularization (CNV) appeared, this probability exceeded 0.7 between ages 45 and 55 for all categories.

Conclusion

The progression rate is lower than in a Japanese series. The vision worsened with disease progression, and the probability of both happening increased after the age of 70–75. If CNV appears, the risk of progression is very high at the age of 45–55.

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Title: Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
Authors: Rosa M. Coco-Martin
Minal Belani-Raju
Daniel de la Fuente-Gomez
María R. Sanabria
Itziar Fernández
Publication date: 01-01-2021
Publisher: Springer Berlin Heidelberg
Keyword: Refractive Errors
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2021
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04795-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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