Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-07-2020 | Trauma

Reduced photoreceptor outer segment layer thickness in mild commotio retinae without ellipsoid zone disruption

Authors: Honghe Xia, Xixuan Ke, Li Jia Chen, Hua Yan, Haoyu Chen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2020

Abstract

Purpose

To quantitatively investigate the reflectivity and structure of the outer retinal layers on spectral-domain optical coherence tomography (SD-OCT) in commotio retinae.

Methods

Nineteen patients with acute macular commotio retinae and 19 age-matched normal controls were examined using SD-OCT. Longitudinal reflectance profiles (LRP) were obtained using Image J. The reflectivity of outer retinal layers was measured at the fovea, 1 mm nasal to fovea and 1 mm temporal to fovea. The reflectivity ratios of outer retinal layers divided by the outer nuclear layer (ONL) were calculated for normalization. Photoreceptor outer segment layer thickness was also measured. The results were compared between the patients and controls.

Results

The reflectivity ratio of ellipsoid zone/ONL and outer segment/ONL was higher in commotio retinae than in controls only at fovea (12.66 ± 4.73 vs 9.67 ± 3.34, p = 0.041; 7.70 ± 2.20 vs 3.73 ± 1.63, p < 0.001, respectively) but not at 1 mm nasal or temporal to the fovea. Photoreceptor outer segment layer thickness was significantly shorter in commotio retinae compared to controls at all three locations (19.64 ± 3.05 vs 25.16 ± 3.53, 16.95 ± 4.02 vs 20.00 ± 3.00, and 15.42 ± 3.22 vs 20.05 ± 2.48, respectively, all p < 0.05).

Conclusions

Quantitative measurement of SD-OCT images revealed that shortening of photoreceptor outer segment is an additional, and potentially better, biomarker for commotio retinae on top of increased reflectivity.

Available only for authorised users

Blanch RJ, Good PA, Shah P, Bishop JR, Logan A, Scott RA (2013) Visual outcomes after blunt ocular trauma. Ophthalmology 120:1588–1591. https://doi.org/10.1016/j.ophtha.2013.01.009 CrossRefPubMed

Souza-Santos F, Lavinsky D, Moraes NS, Castro AR, Cardillo JA, Farah ME (2012) Spectral-domain optical coherence tomography in patients with commotio retinae. Retina 32:711–718. https://doi.org/10.1097/IAE.0b013e318227fd01 CrossRefPubMed

Ahn SJ, Woo SJ, Kim KE, Jo DH, Ahn J, Park KH (2013) Optical coherence tomography morphologic grading of macular commotio retinae and its association with anatomic and visual outcomes. Am J Ophthalmol 156:994–1001 e1001. https://doi.org/10.1016/j.ajo.2013.06.023 CrossRefPubMed

Berlin R (1873) Zur sogenannten commotio retinae. Klin Monatsbl Augenheilkd 1:42–78

Sipperley JO, Quigley HA, Gass DM (1978) Traumatic retinopathy in primates. The explanation of commotio retinae. Arch Ophthalmol 96:2267–2273CrossRef

Ismail R, Tanner V, Williamson TH (2002) Optical coherence tomography imaging of severe commotio retinae and associated macular hole. Br J Ophthalmol 86:473–474CrossRef

Meyer CH, Rodrigues EB, Mennel S (2003) Acute commotio retinae determined by cross-sectional optical coherence tomography. Eur J Ophthalmol 13:816–818CrossRef

Sony P, Venkatesh P, Gadaginamath S, Garg SP (2006) Optical coherence tomography findings in commotio retina. Clin Exp Ophthalmol 34:621–623. https://doi.org/10.1111/j.1442-9071.2006.01290.x CrossRefPubMed

Bradley JL, Shah SP, Manjunath V, Fujimoto JG, Duker JS, Reichel E (2011) Ultra-high-resolution optical coherence tomographic findings in commotio retinae. Arch Ophthalmol 129:107–108. https://doi.org/10.1001/archophthalmol.2010.342 CrossRefPubMedPubMedCentral

10.

Oh J, Jung JH, Moon SW, Song SJ, Yu HG, Cho HY (2011) Commotio retinae with spectral-domain optical coherence tomography. Retina 31:2044–2049. https://doi.org/10.1097/IAE.0b013e31820f4bb4 CrossRefPubMed

11.

Saleh M, Letsch J, Bourcier T, Munsch C, Speeg-Schatz C, Gaucher D (2011) Long-term outcomes of acute traumatic maculopathy. Retina 31:2037–2043. https://doi.org/10.1097/IAE.0b013e31820e8d78 CrossRefPubMed

12.

Chen H, Lu Y, Huang H, Zheng J, Hou P, Chen W (2013) Prediction of visual prognosis with spectral-domain optical coherence tomography in outer retinal atrophy secondary to closed globe trauma. Retina 33:1258–1262. https://doi.org/10.1097/IAE.0b013e31827b63ba CrossRefPubMed

13.

Hartig SM (2013) Basic image analysis and manipulation in ImageJ. Current protocols in molecular biology chapter 14: Unit14.15. https://doi.org/10.1002/0471142727.mb1415s102

14.

Staurenghi G, Sadda S, Chakravarthy U, Spaide RF, International Nomenclature for Optical Coherence Tomography P (2014) Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN*OCT consensus. Ophthalmology 121:1572–1578. https://doi.org/10.1016/j.ophtha.2014.02.023 CrossRefPubMed

15.

Chen X, Hou P, Jin C, Zhu W, Luo X, Shi F, Sonka M, Chen H (2013) Quantitative analysis of retinal layer optical intensities on three-dimensional optical coherence tomography. Invest Ophthalmol Vis Sci 54:6846–6851. https://doi.org/10.1167/iovs.13-12062 CrossRefPubMedPubMedCentral

16.

Michaelides M, Rha J, Dees EW, Baraas RC, Wagner-Schuman ML, Mollon JD, Dubis AM, Andersen MK, Rosenberg T, Larsen M, Moore AT, Carroll J (2011) Integrity of the cone photoreceptor mosaic in oligocone trichromacy. Invest Ophthalmol Vis Sci 52:4757–4764. https://doi.org/10.1167/iovs.10-6659 CrossRefPubMedPubMedCentral

17.

Itakura H, Kishi S (2011) Restored photoreceptor outer segment in commotio retinae. Ophthalmic Surg Lasers Imaging 42:e29–e31. https://doi.org/10.3928/15428877-20110224-03 CrossRefPubMed

18.

Tschulakow AV, Oltrup T, Bende T, Schmelzle S, Schraermeyer U (2018) The anatomy of the foveola reinvestigated. PeerJ 6:e4482. https://doi.org/10.7717/peerj.4482 CrossRefPubMedPubMedCentral

Title: Reduced photoreceptor outer segment layer thickness in mild commotio retinae without ellipsoid zone disruption
Authors: Honghe Xia
Xixuan Ke
Li Jia Chen
Hua Yan
Haoyu Chen
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04678-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Reduced photoreceptor outer segment layer thickness in mild commotio retinae without ellipsoid zone disruption

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 7/2020

Outcome of treatment for neovascular age-related macular degeneration by practice-based ophthalmologists compared with a macula clinic

Increased rate of ptosis following glaucoma drainage device placement and other anterior segment surgery: a prospective analysis

Bare retinal nerve fiber layer and internal limiting membrane tear associated with epiretinal membrane: OCT findings and visual outcomes

Evaluation of the optic nerve head vessel density in the patients with asymmetric pseudoexfoliative glaucoma: an OCT angiography study

The efficacy of modified posterior scleral reinforcement with round scleral patches in Chinese children with high myopia

Evaluation of vision-related quality of life in keratoconus patients, and associated impact of keratoconus severity indicators