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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-12-2019 | Angiography | Retinal Disorders

Impact of integrated multiple image averaging on OCT angiography image quality and quantitative parameters

Authors: Jost L. Lauermann, Y. Xu, P. Heiduschka, M. Treder, F. Alten, N. Eter, M. Alnawaiseh

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2019

Abstract

Purpose

Multiple image averaging (MIA) is a new approach to improve OCT angiography (OCTA) imaging. The aim of this work was to analyze the impact of MIA on image quality and quantitative OCTA parameters.

Methods

Twenty eyes from 20 healthy volunteers (55.65 ± 14.8 years) were prospectively enrolled. Imaging was performed using two commercially available OCTA devices (Canon OCT HS-100, Optovue AngioVue) using a uniform imaging protocol. Each participant had two single scans of the macula (3 × 3mm, Canon and Optovue) as well as five continuous single scan imaging procedures (3 × 3mm each) using the Canon device. Three out of five of these images with highest quality were manually chosen and then automatically processed by the Canon device using MIA.

The superficial retinal plexus of the single scans and of MIA images was analyzed with regard to the device’ own image quality scores (IQS), peak signal-to-noise ratio (PSNR), the size of the foveolar avascular zone (FAZ), and vessel density (VD). Image acquisition times were recorded. Parameters were compared between the devices and the different imaging protocols.

Results

Average acquisition time was significantly higher for the MIA compared with the single measurements (29.09 ± 10.19 seconds (s) (MIA) vs. 5.56 ± 2.17 s (Canon single scan) vs. 20.28 ± 6.81 s (Optovue) (p < 0.001)). IQS showed no significant differences between the devices and between the recording protocols. PSNR was 12.38 ± 0.20 (Canon single scan), 13.01 ± 0.36 (Canon MIA), and 14.34 ± 0.60 (Optovue) (p < 0.001 between the groups). Mean FAZ area in Canon single scans was 0.29 ± 0.06 mm², 0.27 ± 0.07 mm² using MIA, and 0.27 ± 0.08 mm² using the Optovue device. There was no significant difference between mean FAZ measurements before and after averaging (Canon single scan vs. MIA, p = 0.168). VD of the parafoveal area using MIA was significantly lower compared with both single scans (p < 0.001).

Conclusions

MIA can improve PSNR, but it also reduces imaging speed and significantly affects VD measurements. Therefore, when comparing OCTA data, the use of uniform imaging protocols is required.

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Title: Impact of integrated multiple image averaging on OCT angiography image quality and quantitative parameters
Authors: Jost L. Lauermann
Y. Xu
P. Heiduschka
M. Treder
F. Alten
N. Eter
M. Alnawaiseh
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keyword: Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04492-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Impact of integrated multiple image averaging on OCT angiography image quality and quantitative parameters

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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