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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 6/2019

Open Access 01-06-2019 | Glaucoma | Glaucoma

Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width

Authors: Christoph Mitsch, Stephan Holzer, Lorenz Wassermann, Hemma Resch, Susanne Urach, Barbara Kiss, Anton Hommer, Clemens Vass, Ursula Schmidt-Erfurth

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 6/2019

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Abstract

Purpose

The assessment of cup-disc ratio as a surrogate parameter for the neuroretinal rim width (NRW) of the optic nerve is well established, but prone to human error and imprecision. Objective assessment of the NRW is provided by spectral domain optical coherence tomography (SD-OCT). This study is the first to systematically compare NRW measurements acquired with the Carl Zeiss Meditech Cirrus HD-OCT 5000 and the Heidelberg Engineering Spectralis SD-OCT.

Methods

In this cross-sectional study, 20 eyes of each 20 glaucoma patients and 20 age-matched healthy controls underwent ophthalmic examination, SD-OCT imaging, and computer perimetry. Regression analyses were performed for the NRW comparability and the effect of the rotational alignment disconcordance (RAD), receiver-operating characteristics (ROC) for NRW-based healthy glaucoma discrimination capability, and Pearson’s correlation for covariate association.

Results

Mean NRW differences were 8 ± 48 μm (p = 0.4528), 91 ± 80 μm (p < 0.01), and 49 ± 77 μm (p < 0.001) in the glaucoma, healthy, and whole group. On average, the Cirrus showed higher NRW values (+ 50 μm) than the Spectralis, this difference increased with values starting with 159 μm. Discrimination ROC were 1.0 (Spectralis) and 0.9675 (Cirrus). RAD showed very little effect on NRW (R2 = 0.9661, p < 0.001). NRW-covariate correlation was highly significant (p < 0.001) with both devices for clinical cup/disc ratio, calculated rim width, visual field mean, and pattern deviations.

Conclusions

Our results suggest to only cautiously compare Spectralis and Cirrus NRW measurements only in patients with morphologically manifest glaucoma. For morphological progression analysis, we recommend the continuous usage of the same device.
Appendix
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Metadata
Title
Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width
Authors
Christoph Mitsch
Stephan Holzer
Lorenz Wassermann
Hemma Resch
Susanne Urach
Barbara Kiss
Anton Hommer
Clemens Vass
Ursula Schmidt-Erfurth
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Keyword
Glaucoma
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 6/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04299-x

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