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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-09-2018 | Glaucoma

The distribution of retinal nerve fiber layer thickness and associations with age, refraction, and axial length: the Gutenberg health study

Authors: Esther M. Hoffmann, Irene Schmidtmann, Angeliki Siouli, Alexander K. Schuster, Manfred E. Beutel, Norbert Pfeiffer, Julia Lamparter

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2018

Abstract

Purpose

To evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting.

Methods

In the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany). The associated factors in the global and sectoral pRNFL data were analyzed using multivariable linear mixed models related to age, sex, and ocular parameters.

Results

Advanced age and longer axial length were associated with a thinner pRNFL, whereas pRNFL thickness was independent of sex, intraocular pressure (IOP), and central corneal thickness (CCT). Spherical equivalent was positively associated with pRNFL thickness, except in the temporal pRNFL sector.

Conclusions

In this large, population-based study, pRNFL thickness decreased with age. Longer eyes had thinner pRNFL thickness. Sex, IOP, and CCT showed no significant association with pRNFL thickness. These data may improve the interpretation of pRNFL data.

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Title: The distribution of retinal nerve fiber layer thickness and associations with age, refraction, and axial length: the Gutenberg health study
Authors: Esther M. Hoffmann
Irene Schmidtmann
Angeliki Siouli
Alexander K. Schuster
Manfred E. Beutel
Norbert Pfeiffer
Julia Lamparter
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-3991-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The distribution of retinal nerve fiber layer thickness and associations with age, refraction, and axial length: the Gutenberg health study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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