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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-02-2018 | Review Article

Optical coherence tomography angiography: a review of current and future clinical applications

Authors: Marcus Ang, Anna C. S. Tan, Chui Ming Gemmy Cheung, Pearse A. Keane, Rosa Dolz-Marco, Chelvin C. A. Sng, Leopold Schmetterer

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2018

Abstract

Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the caveats to the interpretation of images. As current optical coherence tomography angiography systems are optimized for the retina, most studies have focused on interpreting images from conditions such as age related macular degeneration and retinal vascular diseases. However, the interpretation of these optical coherence tomography angiography images should be taken in consideration with other multi-modal imaging to overcome the limitations of each technique. In addition, there are a growing variety of clinical applications for optical coherence tomography angiography imaging in optic nerve head evaluation for glaucoma and optic neuropathies. Further developments in anterior optical coherence tomography angiography have now allowed for evaluation of anterior segment pathology such as glaucoma, ocular surface diseases, corneal vascularisation, and abnormal iris vasculature. Future developments in software could allow for improved segmentation and image resolution with automated measurements and analysis.

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Title: Optical coherence tomography angiography: a review of current and future clinical applications
Authors: Marcus Ang
Anna C. S. Tan
Chui Ming Gemmy Cheung
Pearse A. Keane
Rosa Dolz-Marco
Chelvin C. A. Sng
Leopold Schmetterer
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-017-3896-2

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Optical coherence tomography angiography: a review of current and future clinical applications

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