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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2017 | Retinal Disorders

Quantitative analysis of external limiting membrane, ellipsoid zone and interdigitation zone defects in patients with macular holes

Authors: Jacques Ramos Houly, Carlos Eduardo Veloso, Elke Passos, Márcio Bittar Nehemy

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2017

Abstract

Purpose

To investigate the correlation between the length of external limiting membrane (ELM), ellipsoid zone (EZ) and interdigitation zone (IZ) defects and visual prognosis in patients undergoing macular hole (MH) surgery, using spectral-domain optical coherence tomography (SD-OCT).

Methods

This is a retrospective, consecutive, observational case series study. Fifty-two eyes of 52 patients with primary MH were evaluated. A quantitative analysis of ELM, EZ and IZ defects was performed preoperatively and at 3 and 6 months postoperatively using SD-OCT. The correlation between pre- and postoperative ELM, EZ and IZ defects and the best-corrected visual acuity (BCVA) was investigated.

Results

The lengths of ELM, EZ and IZ defects correlated significantly with BCVA in each study period (P < 0.001). Preoperative measures of these band defects were also associated with visual outcomes 3 and 6 months after surgery (P < 0.05). Considering all preoperative parameters, the length of the ELM defect was the factor most strongly correlated with BCVA at 6 months (β = 0.643, P < 0.012). The integrity of the ELM was the only factor significantly associated with BCVA at 6 months (β = 0.427; P = 0.004).

Conclusions

The preoperative length of the ELM defect is the strongest predictor of visual acuity after MH surgery. Postoperative integrity of the ELM is significantly associated with visual restoration after surgical treatment of MH.

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Title: Quantitative analysis of external limiting membrane, ellipsoid zone and interdigitation zone defects in patients with macular holes
Authors: Jacques Ramos Houly
Carlos Eduardo Veloso
Elke Passos
Márcio Bittar Nehemy
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2017
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-017-3636-7

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Quantitative analysis of external limiting membrane, ellipsoid zone and interdigitation zone defects in patients with macular holes

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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