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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2016 | Oncology

Trabeculectomy in patients with uveal melanoma after proton beam therapy

Authors: Aline I. Riechardt, Dino Cordini, Matus Rehak, Annette Hager, Ira Seibel, Alexander Böker, Enken Gundlach, Jens Heufelder, Antonia M. Joussen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2016

Abstract

Background

Retrospective evaluation of intraocular pressure, use of topical and systemic anti-glaucoma medication, secondary complications, local tumor control and survival in patients treated with trabeculectomy for the regulation of the intraocular pressure (IOP) after proton beam therapy for uveal melanoma.

Methods

In this retrospective clinical case series we evaluated the follow-up of 15 patients receiving a trabeculectomy as surgical treatment if the IOP could not be lowered adequately by medications or laser surgery. All patients had received proton beam therapy for uveal melanoma at the Helmholtz-Zentrum Berlin between 1998 and 2010.

Results

The median IOP decreased significantly from 35 mmHg ± 8.8 before TE to 16 mmHg ± 8.2 (=52.3 %) six months after TE (Wilcoxon-Mann–Whitney-U Test, p<0.01). None of the patients needed any glaucoma medication six months after trabeculectomy. Two patients developed local recurrence during follow-up, which were independent of the trabeculectomy. One patient had to be enucleated due to intractable pain and suspected remaining tumor activity. One patient died due to metastasis.

Conclusions

Trabeculectomy is an option in intractable glaucoma in patients with uveal melanoma after proton beam therapy in single cases. Secondary interventions are common. Inoculation metastases are possible. Secure local tumor control must be a prerequisite for filtrating operations.

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Title: Trabeculectomy in patients with uveal melanoma after proton beam therapy
Authors: Aline I. Riechardt
Dino Cordini
Matus Rehak
Annette Hager
Ira Seibel
Alexander Böker
Enken Gundlach
Jens Heufelder
Antonia M. Joussen
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2016
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-016-3310-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Trabeculectomy in patients with uveal melanoma after proton beam therapy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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