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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 7/2016

01-07-2016 | Retinal Disorders

Minimally fibrotic stage 5 ROP: a clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity

Authors: Salil S Gadkari, Madan Deshpande, Sucheta Kulkarni

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2016

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Abstract

Title

Minimally fibrotic Stage 5: A clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity (ROP).

Purpose

To define minimally fibrotic stage 5 ROP and to demonstrate better surgical outcomes in this subgroup.

Methods

A cohort of eligible eyes with stage 5 ROP undergoing vitrectomy were further divided into those with minimally fibrotic stage 5 and others. Minimally fibrotic stage 5 ROP was defined as those stage 5 eyes having a translucent retrolental membrane with visibility of the underlying retinal vessels and absence of anteriorly rotated ciliary processes. We reported on anatomic and visual outcomes in eyes with defined characteristics of this subgroup identified before surgery and then observing them post vitrectomy over a period of time as compared to others.

Results

Minimally fibrotic stage 5 eyes had better visual (p = .0068) and anatomical outcomes (p = .0001).

Conclusion

Minimally fibrotic stage 5 ROP shows ridge to ridge traction that has resulted in a traction retinal detachment with a retrolental membrane, but fibrotic change has just begun. This stage 5 ROP with limited fibrosis represents a subset of this stage 5 ROP with a positive anatomic and visual prognosis.
Literature
1.
Machemer R (1983) Closed vitrectomy for severe retrolental fibroplasias in the infant. Ophthalmology 90:436–441CrossRefPubMed
2.
Trese MT (1984) Surgical results of stage V retrolental fibroplasias and timing of surgical repair. Ophthalmology 91:461–466CrossRefPubMed
3.
Trese MT (1986) Visual results and prognostic factors for visionfollowing surgery for stage V retinopathy of prematurity. Ophthalmology 93:574–579CrossRefPubMed
4.
Chong LP, Machemer R, deJuan E (1986) Vitrectomy for advanced stages of retinopathy of prematurity. Am J Ophthalmol 102:710–716CrossRefPubMed
5.
Tasman W, Borrone RN, Bolling J (1987) Open sky vitrectomy for total retinal detachment in retinopathy of prematurity. Ophthalmology 94:449–452CrossRefPubMed
6.
Zillis JD, deJuan E, Machemer R (1990) Advanced retinopathy of prematurity: the anatomical and visual results of vitreous surgery. Ophthalomology 97:821–826CrossRef
7.
Quinn GE, Dobson V, Barr CC et al (1991) Visual acuity in infants after vitrectomy for severe retinopathy of prematurity. Ophthalmology 98:5–13CrossRefPubMed
8.
Fuchino Y, Hayashi H, Kono T, Ohshima K (1995) Long-term follow-up of visual acuity in eyes with stage 5 retinopathy of prematurity after closed vitrectomy. Am J Ophthalmol 120:308–316CrossRefPubMed
9.
Quinn GE, Dobson V, Barr CC et al (1996) Visual acuity of eyes after vitrectomy for retinopathy of prematurity: follow-up at 5 ½ years. Ophthalmology 103:595–600CrossRefPubMed
10.
Trese MT, Droste PJ (1998) Long-term postoperative results of a consecutive series of stages 4 and 5 retinopathy of prematurity. Ophthalmology 105:992–997CrossRefPubMed
11.
Choi MY, Yu YS (1998) Anatomical and visual results of vitreous surgery for advanced retinopathy of prematurity. Korean J Ophthalmol 12:60–67CrossRefPubMed
12.
Kono T, Oshima K, Fuchino Y (2000) Surgical results and visual outcomes of vitreous surgery for advanced stages of retinopathy of prematurity. Jpn J Ophthalmol 44:661–667CrossRefPubMed
13.
Lakhanpal RR, Sun RL, Albini TA, Holz ER (2006) Anatomical success rate after primary three-port lens-sparing vitrectomy in stage 5 retinopathy of prematurity. Retina 26:724–728CrossRefPubMed
14.
Fielder AR (1997) Retinopathy of prematurity. Community Eye Health J 10:17–19
15.
16.
Jalali S, Anand R, Kumar H, Dogra MR, Azad R, Gopal L (2003) Programme planning and screening strategy in retinopathy of prematurity. Indian J Ophthalmol 51:89–99PubMed
17.
Jalali S, Hussain A, Matalia J, Anand R (2006) Modification of screening criteria for India and other middle income group countries. Am J Ophthalmol 141:966–8CrossRefPubMed
18.
ICROP Committee for the classification of late stages of retinopathy of prematurity, II (1987) The classification of retinal detachment. Arch Ophthalmol 105:906–12CrossRef
19.
Early Treatment for Retinopathy of Prematurity Cooperative Group (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomised trial. Arch Ophthalmol 121:1684–96CrossRefPubMed
20.
Seaber JH, Machemer R, Eliott D et al (1995) Long-term visual results of children after initially successful vitrectomy for stage V retinopathy of prematurity. Ophthalmology 102:199–204CrossRefPubMed
21.
Gadkari S, Kamdar RR, Kulkarni S et al (2015) Vision development over an extended follow-up period in babies after successful vitrectomy for stage 4b retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 253(5):705–11CrossRefPubMed
22.
Algvere P, Kock E (1976) Experimental fibroplasia in the rabbit vitreous. Retinal detachment induced by autologous fibroblasts. Albrecht von Graefes Arch Klin Ophthalmol 199:215–22CrossRef
23.
24.
Woo KI, Kwak SI, Yu YS (1992) The components of the proliferative membranes in retinopathy of prematurity: an electron microscopic study. Korean J Ophthalmol 6(1):36–43CrossRefPubMed
25.
Gadkari SS, Kamdar RR, Kulkarni SR et al (2015) Vitreoretina surgery for advanced ROP : presentation and outcomes from a developing country. Can J Ophthalmol 50(1):54–60CrossRefPubMed
26.
Hartnett ME, McColm JR (2006) Fibrovascular organization in the vitreous following laser for ROP: implications for prognosis. Retina 26(7 Suppl):S24–31CrossRefPubMedPubMedCentral
Metadata
Title
Minimally fibrotic stage 5 ROP: a clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity
Authors
Salil S Gadkari
Madan Deshpande
Sucheta Kulkarni
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2016
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-015-3197-6

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