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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2016 | Retinal Disorders

ANGPTL-4 correlates with vascular endothelial growth factor in patients with proliferative diabetic retinopathy

Authors: Qianyi Lu, Wenjun Zou, Bin Chen, Chen Zou, Minjie Zhao, Zhi Zheng

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2016

Abstract

Purpose

To investigate the relationship between angiopoietin-like protein 4 (ANGPTL-4) and vascular endothelial growth factor (VEGF) in the serum and vitreous of eyes in patients with proliferative diabetic retinopathy (PDR).

Methods

Thirty-five eyes of 35 patients with PDR, 20 eyes of 20 patients with non-proliferative diabetic retinopathy, 20 eyes of 20 patients with diabetes but no diabetic retinopathy, and 14 eyes of 14 nondiabetic patients with an idiopathic macular hole (IMH) were recruited from Shanghai First People’s Hospital. The ANGPTL-4 and VEGF concentrations were determined using enzyme-linked immunosorbent assays. Group means were compared using one-way analysis of variance with GraphPad Prism 4.0 and SPSS ver. 17.0. The research followed the tenets of the Declaration of Helsinki.

Results

The ANGPTL-4 and VEGF levels were significantly higher in the vitreous and serum of patients with PDR compared with patients with IMH. There were significant correlations between the ANGPTL-4 and VEGF levels in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated in patients with PDR. The ANGPTL-4 in both the vitreous and serum correlated with the serum triglyceride and high-density lipoprotein cholesterol levels.

Conclusions

The ANGPTL-4 levels were markedly elevated and the ANGPTL-4 expression was directly correlated with the VEGF expression in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated with serum lipids in patients with PDR. Our results suggest that the ANGPTL-4 may be used as a new therapeutic target for the treatment of PDR.

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Title: ANGPTL-4 correlates with vascular endothelial growth factor in patients with proliferative diabetic retinopathy
Authors: Qianyi Lu
Wenjun Zou
Bin Chen
Chen Zou
Minjie Zhao
Zhi Zheng
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2016
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-3187-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

ANGPTL-4 correlates with vascular endothelial growth factor in patients with proliferative diabetic retinopathy

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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