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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-11-2015 | Genetics

The rs3917779 polymorphism of P-selectin’s significant association with proliferative diabetic retinopathy in Yazd, Iran

Authors: Parisa Kolahdouz, Ehsan Farashahi Yazd, Masoud Tajamolian, Masoud Reza Manaviat, Mohammad Hasan Sheikhha

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2015

Abstract

Purpose

This study aims at investigating possible associations of P-selectin polymorphisms with proliferative diabetic retinopathy (PDR) in Yazd, Iran.

Methods

The subjects of the study included of 55 PDR and 55 diabetic no retinopathy (DNR) cases attending Yazd Diabetes Research Center (YDRC). P-selectin genotyping was done by an ARMS-PCR method.

Results

The P-selectin variants rs6128, rs6133, and rs3917779 were not in Hardy-Weinberg equilibrium. The frequency of the rs3917779 C allele (P < 0.0001), but not the rs6133 G allele (P = 0.19) or rs6128 allele (P = 0.20), was higher in PDR cases than in control DNR cases. Significant differences in the distribution of rs3917779 (P < 0.001), but not rs6128 (P = 0.52) or rs6133 (P = 0.18), genotypes were observed between cases and controls, and only rs3917779 showed a significant association with PDR, with increments of 49.2 (14.72–125.07) in disease risk seen for CC genotypes. Among the eight three-locus P-selectin haplotypes constructed (rs6128 / rs6133 / rs3917779), there was no significant difference between frequencies of haplotypes in the DNR and PDR groups.

Conclusions

P-selectin gene polymorphisms and haplotypes can contribute to PDR development.

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Title: The rs3917779 polymorphism of P-selectin’s significant association with proliferative diabetic retinopathy in Yazd, Iran
Authors: Parisa Kolahdouz
Ehsan Farashahi Yazd
Masoud Tajamolian
Masoud Reza Manaviat
Mohammad Hasan Sheikhha
Publication date: 01-11-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-3141-9

At a glance: The STEP trials

Springer Medicine

The rs3917779 polymorphism of P-selectin’s significant association with proliferative diabetic retinopathy in Yazd, Iran

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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