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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2015 | Cornea

Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT

Authors: David Kuerten, Niklas Plange, Eva Charlotte Koch, Antonis Koutsonas, Peter Walter, Matthias Fuest

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2015

Abstract

Purpose

The purpose of this study is to determine the influence of post-surgical corneal edema on the reliability and reproducibility of central corneal thickness (CCT) measurements by a Scheimpflug camera (Pentacam), ultrasound pachymetry (USP), and anterior-segment spectral-domain optical coherence tomography (AS-OCT).

Methods

Thirty-two patients planned for cataract surgery (n = 16) or vitrectomy (n = 6) were included in a prospective study. The non-surgery eye was used as control. Two investigators acquired two measurements each, with the Pentacam (Oculus, Germany) and the AS-OCT (Heidelberg Engineering, Germany) in a randomized order, followed by USP (Tomey SP-100, Germany). CCT was evaluated using the apex value for Pentacam, the corneal apex cut in AS–OCT and averaging eight single measurements for USP. Coefficients of variation (COV) and intra-class correlation coefficients (ICC) were determined.

Results

Post-surgery corneas showed a thickness of (investigators 1 and 2): Pentacam (615.9 ± 58.02 μm and 615.1 ± 60.17 μm), USP (601.4 ± 63.77 μm and 614.5 ± 70.91 μm), AS-OCT (608.8 ± 65.67 μm and 606.9 ± 64.41 μm) ,with no significant difference (ANOVA p > 0.99). The COVs (investigators 1 and 2) for control eyes were: Pentacam (0.78 ± 0.52 and 0.70 ± 0.76), USP (0.66 ± 0.29 and 0.98 ± 0.44), AS-OCT (0.59 ± 0.61 and 0.59 ± 0.40). The COVs (investigators 1 and 2) for post-surgical eyes were: Pentacam (0.98 ± 1.25 and 0.97 ± 0.73), USP (0.73 ± 0.64 and 1.35 ± 0.85), AS-OCT (1.34 ± 1.57 and 1.19 ± 1.18).The ICC was determined in post-surgery corneas (ICC > 0.96) and control corneas (ICC > 0.95).

Conclusion

USP measurements have the highest user dependence. Post-surgical corneal edema leads to higher intraobserver variability. All methods reached a high level of agreement in CCT determination in edematous as well as healthy corneas.

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Title: Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT
Authors: David Kuerten
Niklas Plange
Eva Charlotte Koch
Antonis Koutsonas
Peter Walter
Matthias Fuest
Publication date: 01-07-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-015-2998-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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