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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 6/2014

Open Access 01-06-2014 | Basic Science

The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits

Authors: Dorota Szumny, Adam Szeląg

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 6/2014

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Abstract

Background

The aim of this study was to assess the influence of propranolol, nebivolol, and carvedilol on intraocular pressure and blood flow in vessels of rabbit’s (New Zealand White) eyeball.

Methods

The study was carried out on New Zealand white rabbits. Intraocular pressure was measured with the applanation tonometer Möller–Wedel and Icare; blood flow was measured with Doppler Laser Blood Flow Monitor MBD3.

Results

Following a single administration into a conjunctival sac, all drugs decreased intraocular pressure. Iris blood flow was decreased following administration of propranol, but increased by nebivolol and carvedilol. After single and repeated oral administration of nebivolol and carvedilol an IOP decrease was demonstrated, but with no effect of all applied doses on iris or retina/choroid blood flow.

Conclusion

Studies performed on an animal model indicate that it is possible to reduce the intraocular pressure and increase ocular blood flow in humans, following topical administration of carvedilol and nebivolol. Confirmation of those results in clinical trials may lead to development of a new anti-glaucoma treatment. Further clinical studies of long-term nebivolol and carvedilol are recommended. They are necessary for evaluation of usefulness of those drugs for selected groups of patients, for example those with glaucoma and arterial hypertension.
Literature
1.
Cherecheanu AP, Garhofer G, Schmidl D, Werkmeister R, Schmetterer L (2013) Ocular perfusion pressure and ocular blood flow in glaucoma. Curr Opin Pharmacol 13:36–42PubMedCentralPubMedCrossRef
2.
Elena PP, Kosina-Boix M, Moulin G, Lapalus P (1987) Autoradiographic localization of beta-adrenergic receptors in rabbit eye. Ophthalmol Vis Sci 28:1436–1441
3.
Pournaras CJ, Rungger-Braendle E, Riva CE, Hardarson H, Stefansson E (2008) Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 27:284–330PubMedCrossRef
4.
Nilsson SFE (1996) Nitric oxide as a mediator of parasympathetic vasodilation in ocular and extraocular tissues in the rabbit. Invest Ophthalmol Vis Sci 37:2110–2119PubMed
5.
Kotikoski H, Alajuuma P, Moilanen E, Salmenpera P, Oksala O, Laippala P et al (2002) Comparison of nitric oxide donors in lowering Intraocular pressure in rabbits: role of cyclic GMP. J Ocul Pharmacol Ther 18:11–23PubMedCrossRef
6.
Chung HS, Harris A, Evans DW, Kagemann L, Garzozi HJ, Martin B (1999) Vascular aspects in the pathophysiology of glaucomatous optic neuropathy. Surv Ophthalmol 43:43–50CrossRef
7.
Delaney Y, Walshe TE, O’Brien C (2006) Vasospasm in glaucoma: clinical and laboratory aspects. Optom Vis Sci 83:406–414PubMedCrossRef
8.
Krasinska B, Banach M, Karolczak-Kulesza M, Krasinski Z, Gluszek J, Tykarski A (2012) Observations on degenerative changes within the optic nerve in patients with primary open glaucoma and arterial hypertension: 6-month follow-up. J Clin Hypertens (Greenwich, Conn) 14:701–710CrossRef
9.
Muzyka M, Nizankowska MH, Koziorowska M, Zajac-Pytrus H (1997) Occurrence of nocturnal arterial hypotension in patients with primary open-angle glaucoma and normal tension glaucoma. Klin Ocz 99:109–113
10.
Shoshani Y, Harris A, Shoja MM, Arieli Y, Ehrlich R, Primus S et al (2012) Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. Clin Exp Ophthalmol 40:697–705CrossRef
11.
Grunwald J, Piltz J (1999) Optic nerve blood flow in glaucoma: effect of systemic hypertension — Author reply. Am J Ophthalmol 128:664CrossRef
12.
Kanno M, Araie M, Tomita K, Sawanobori K (1998) Effects of topical nipradilol, a beta-blocking agent with alpha-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation. Invest Ophthalmol Vis Sci 39:736–743PubMed
13.
Maffei A, Vecchione C, Aretini A, Poulet R, Bettarini U, Gentile MT, Cifelli G, Lembo G (2006) Characterization of nitric oxide release by nebivolol and its metabolites. Am J Hypertens 19:579–586PubMedCrossRef
14.
Tzemos N, Lim PO, MacDonald TM (2001) Nebivolol reverses endothelial dysfunction in essential hypertension — A randomized, double-blind, crossover study. Circulation 104:511–514PubMedCrossRef
15.
Boydak B, Nalbantgil S, Fici F, Nalbantgil I, Zoghi M, Ozerkan F, Tenquiz I, Ercan E, Yilmaz H, Yoket U, Onder R (2005) A randomised comparison of the effects of nebivolol and atenolol with and without chlorthalidone on the sexual function of hypertensive men. Clin Drug Investig 25:409–416PubMedCrossRef
16.
Ritt M, Harazny JM, Ott C, Raff U, Schneider MP, Michelson G, Schmieder RE (2011) Basal nitric oxide activity is an independent determinant of arteriolar structure in the human retinal circulation. J Hypertens 29:123–129PubMedCrossRef
17.
Okuno T, Oku H, Sugiyama T, Yang Y, Ikeda T (2002) Evidence that nitric oxide is involved in autoregulation in optic nerve head of rabbits. Invest Ophthalmol Vis Sci 4:784–789
18.
Matsuda Y, Akita H, Terashima M, Shiga N, Kanazawa K, Yokoyama M (2000) Carvedilol improves endothelium-dependent dilatation in patients with coronary artery disease. Am Heart J 140:753–759PubMedCrossRef
19.
Krzyzanowska-Berkowska P, Asejczyk-Widlicka M (2010) Clinical evaluation of the ICare tonometer in measuring intraocular pressure. Klin Ocz 112:217–220
20.
Pouliot M, Deschenes MC, Hetu S, Chemtob S, Lesk MR, Couture R, Vaucher E (2009) Quantitative and regional measurement of retinal blood flow in rats using N-isopropyl-p- C-14 -iodoamphetamine ( C-14 -IMP). Exp Eye Res 89:960–966PubMedCrossRef
Metadata
Title
The influence of new beta-adrenolytics nebivolol and carvedilol on intraocular pressure and iris blood flow in rabbits
Authors
Dorota Szumny
Adam Szeląg
Publication date
01-06-2014
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 6/2014
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-014-2623-5

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