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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-03-2014 | Medical Ophthalmology

The extended clinical phenotype of dome-shaped macula

Authors: Marie-Hélène Errera, Michel Michaelides, Pearse A. Keane, Marie Restori, Michel Paques, Anthony T. Moore, Jonathan Yeoh, Derek Chan, Catherine A. Egan, Praveen J. Patel, Adnan Tufail

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2014

Abstract

Purpose

To describe the phenotype, associations, and complications of dome-shaped macula (DSM) through the combination of spectral-domain optical coherence tomography (OCT) imaging and B-scan ultrasonography, when available. This retroprospective cohort study aims to gain further pathophysiological understanding in eyes with DSM.

Methods

Fifty-eight eyes of 36 patients were identified as having OCT features of DSM. Retinal and choroidal thicknesses were determined from enhanced depth imaging (EDI)-OCT image sets, with scleral thickness subsequently calculated by subtraction from the B-scan ultrasound-derived measurements of posterior coat thickness.

Results

DSM was associated with myopia in 81 % of eyes. The underlying clinical diagnosis was variable: central serous chorioretinopathy (CSCR)-like entity, choroidal neovascularization, and inherited retinal disorders. The subfoveal choroidal thickness of the nine highly myopic eyes with a CSCR-like phenotype was thicker than the 25 eyes without CSCR (p = 0.169). The mean subfoveal scleral thickness of the highly myopic eyes was 585 ± 196 μm, which was significantly different from those with a refractive error less than 6 diopters (1133 ± 290 μm) (P < 0.0001).

Conclusions

This study highlights the novel observation of a thickened choroid when CSCR is present. In addition, we expand the associations of DSM to eyes with hypermetropia and acquired disease, and to those with inherited retinal dystrophies.

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Title: The extended clinical phenotype of dome-shaped macula
Authors: Marie-Hélène Errera
Michel Michaelides
Pearse A. Keane
Marie Restori
Michel Paques
Anthony T. Moore
Jonathan Yeoh
Derek Chan
Catherine A. Egan
Praveen J. Patel
Adnan Tufail
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2014
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-013-2561-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The extended clinical phenotype of dome-shaped macula

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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