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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-01-2014 | Glaucoma

Baseline thickness of macular ganglion cell complex predicts progression of visual field loss

Authors: Ayako Anraku, Nobuko Enomoto, Asuka Takeyama, Hiroyuki Ito, Goji Tomita

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2014

Abstract

Background

Previous studies reported that the thickness of the macular ganglion cell complex (mGCC) showed good diagnostic ability for detecting glaucoma. However, its impact on the progression of visual field loss in primary open angle glaucoma (POAG) is unknown. The purpose of this study was to assess whether baseline mGCC thickness is associated with the progression of visual field loss in POAG.

Methods

Fifty-six patients with POAG were included in the study. All patients were followed for more than 2 years after baseline optical coherence tomography (OCT) measurements. They had at least five reliable Humphrey visual field tests with 30–2 Swedish Interactive Threshold Algorithm standard tests during the follow-up period. The subjects were divided into two groups according to the slope of the mean deviation (MD): the fast progression group (MD slope < −0.4 dB/y) and the slow progression group (MD slope ≥ −0.4 dB/y). Factors compared between the groups were as follows: age, baseline intraocular pressure (IOP), mean IOP during the follow-up, refraction, baseline MD, pattern standard deviation (PSD), and baseline OCT measurements.

Results

There were no significant differences between the two groups in age, baseline IOP, mean IOP during the follow-up, refraction, baseline MD or PSD, average thickness of retinal nerve fiber layer (RNFL), or disc parameters. However, the baseline mGCC thickness (average and inferior hemifield) was significantly thinner in the fast progression group than in the slow progression group (74.0 ± 7.2 μm vs. 80.3 ± 8.6 μm; 68.0 ± 6.6 μm vs. 78.2 ± 11.6 μm, respectively). Moreover, global loss volume and focal loss volume, which are parameters of mGCC, showed significantly higher rates in the fast progression group than in the slow progression group. In multivariate analysis, only mGCC thickness of the inferior hemifield was associated with disease progression (P = 0.007).

Conclusions

Baseline mGCC thickness can be predictive of progressive visual field loss in patients with POAG.

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Title: Baseline thickness of macular ganglion cell complex predicts progression of visual field loss
Authors: Ayako Anraku
Nobuko Enomoto
Asuka Takeyama
Hiroyuki Ito
Goji Tomita
Publication date: 01-01-2014
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2014
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-013-2527-9

At a glance: The STEP trials

Springer Medicine

Baseline thickness of macular ganglion cell complex predicts progression of visual field loss

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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