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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 10/2013

01-10-2013 | Glaucoma

The glaucoma detection capability of spectral-domain OCT and GDx-VCC deviation maps in early glaucoma patients with localized visual field defects

Authors: Jung Hwa Na, Kyoung Sub Lee, Jong Rak Lee, Youngrok Lee, Michael S. Kook

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 10/2013

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Abstract

Purpose

To evaluate and compare the glaucoma detection capabilities afforded by retinal nerve fiber layer (RNFL) thickness and deviation maps obtained using Cirrus spectral domain optical coherence tomography (Cirrus OCT), and GDx employing variable corneal compensation (GDx-VCC) in glaucoma patients with early, localized visual field (VF) loss.

Methods

This prospective controlled, comparative study was performed on 42 eyes with localized VF defects, and 42 age/refractive error-matched healthy eyes. All participants were imaged by both imaging devices at the same visit. The area of the RNFL defect in each deviation map, corresponding to a VF defect, was analyzed by direct counting of color-coded superpixels in each device. Receiver operating characteristic (ROC) curves were constructed and compared between Cirrus OCT and GDx-VCC.

Results

The areas under the ROCs (AUCs) of RNFL quadrant thicknesses in hemifields with visual field (VF) defects did not differ significantly (Cirrus OCT; 0.961, GDx-VCC; 0.919, P = 0.07). However, Cirrus OCT afforded a better diagnostic ability, by deviation map analysis, than did GDx-VCC (0.972 vs 0.887, P = 0.02).

Conclusions

The RNFL thicknesses assessed by either Cirrus OCT or GDx-VCC were comparable in terms of early glaucoma diagnostic capability. However, when areas containing RNFL defects were analyzed via deviation mapping, Cirrus OCT was better than GDx-VCC.
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Metadata
Title
The glaucoma detection capability of spectral-domain OCT and GDx-VCC deviation maps in early glaucoma patients with localized visual field defects
Authors
Jung Hwa Na
Kyoung Sub Lee
Jong Rak Lee
Youngrok Lee
Michael S. Kook
Publication date
01-10-2013
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 10/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-013-2362-z

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